Full-Time

Senior Scientist II

Large Scale Biotherapeutic Purification

Posted on 8/29/2024

Generate Biomedicines

Generate Biomedicines

201-500 employees

Generates novel medicines using generative biology

AI & Machine Learning
Biotechnology

Senior, Expert

Cambridge, MA, USA + 1 more

More locations: Andover, MA, USA

Role requires frequent travel between Somerville and Andover sites.

Category
Bioinformatics
Biology Lab & Research
Biology & Biotech
Required Skills
Data Analysis
Requirements
  • Minimum of 6+ years/PhD or 12+ years/MSc in a biotech/pharma industry setting.
  • Experience with standard chromatography methods in the Biotherapeutic Discovery and Development setting (Protein A, IEX, HIC, mixed mode, SEC).
  • Knowledge of how to implement QC requirements with a variety of downstream in-vitro and in-vivo uses.
  • Track record of using an array of analytical techniques to drive preparative workflows and define final product quality.
  • 3+ years of people management experience leading a team.
  • Excellent communication, attention to detail, documentation and technical writing skills.
  • Align with manufacturability from a purification perspective (e.g. resins, wash steps, flow though/weak partitioning, formulating).
Responsibilities
  • Guides rigorous data analysis, interpretation, and communication by monitoring and conducting complex data analysis and interpretation and ensuring high quality and reliability of data across multiple experimental data sets and projects.
  • Interpret complex data and providing guidance on troubleshooting challenging issues with the experiment; and leading the implementation of new digital tools or strategies.
  • Builds, coaches, and mentors a team of high-performing scientists by identifying and recommending new approaches and improvements that can be incorporated into development plans.
  • Lead and facilitate discussions with cross-functional teams on own lab or project team's work to drive success of multiple projects.
  • Guide multi-step protein purifications of various protein modalities leveraging different affinity tags, secondary chromatography and polishing steps on AKTA systems.
  • Assess protein quality metrics for all proteins produced within team.
  • Explore, assess, and bring in-house state of the art technologies to enhance and continuously improve efficiencies across internal platforms.
  • Manage all protein purification activities in group being accountable for planning, prioritization, and on-time delivery of generated protein variants.
  • Efficiently accomplish project goals on time and budget, tracking capacity constraints and resource use within team.
  • Collaborate and coordinate with upstream DNA and protein expression teams.
  • Encourage and help coordinate cross-training of sub-disciplines when appropriate.
  • Serve as a subject matter expert in recombinant protein production to different cross-functional teams.
  • Detailed documentation of experiments and data on our internal LIMS systems, electronic notebook and presentations to project teams.
  • Drive discussions with downstream stable CHO production groups for manufacturability.
  • Program leadership in the form of departmental representation.
Generate Biomedicines

Generate Biomedicines

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Generate Biomedicines focuses on creating new medicines by combining machine learning, biological engineering, and medicine. The company uses a method called generative biology, which involves analyzing millions of proteins to learn how nature encodes their functions. This knowledge allows them to design new medicines with specific therapeutic effects. Their main product, The Generate Platform, enables the rapid production of medicines across various therapeutic areas, making the drug discovery process more efficient compared to traditional methods. Unlike other companies in the biotechnology and pharmaceutical sectors, Generate Biomedicines emphasizes a proactive approach to medicine creation. Their goal is to democratize access to biotherapeutics, and they have already generated and tested 42,000 proteins, with plans for further expansion.

Company Stage

Series C

Total Funding

$674.1M

Headquarters

Somerville, Massachusetts

Founded

2018

Growth & Insights
Headcount

6 month growth

0%

1 year growth

0%

2 year growth

1%
Simplify Jobs

Simplify's Take

What believers are saying

  • Generative AI is enhancing Generate Biomedicines' drug discovery capabilities.
  • Strategic alliances, like with Novartis, leverage AI for drug development.
  • Samsung's investment indicates strong market confidence in Generate Biomedicines.

What critics are saying

  • Intellectual property disputes may arise as the generative biology platform expands.
  • Technological advancements may render current platforms obsolete without continuous innovation.
  • Reliance on partnerships could pose risks if collaborations don't meet expectations.

What makes Generate Biomedicines unique

  • Generate Biomedicines uses generative biology to create protein-based medicines efficiently.
  • The Generate Platform allows rapid production of medicines across multiple therapeutic areas.
  • The company integrates machine learning with biological engineering for innovative drug discovery.

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