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Full-Time

Senior Scientist II

Large Scale Biotherapeutic Purification

Confirmed live in the last 24 hours

Generate Biomedicines

Generate Biomedicines

51-200 employees

Generates novel medicines using machine learning

AI & Machine Learning
Biotechnology
Healthcare

Senior, Expert

Cambridge, MA, USA + 1 more

Category
Bioinformatics
Biology Lab & Research
Biology & Biotech
Required Skills
Data Analysis
Requirements
  • Minimum of 6+ years/PhD or 12+ years/MSc in a biotech/pharma industry setting.
  • Experience with standard chromatography methods in the Biotherapeutic Discovery and Development setting (Protein A, IEX, HIC, mixed mode, SEC).
  • Knowledge of how to implement QC requirements with a variety of downstream in-vitro and in-vivo uses.
  • Track record of using an array of analytical techniques to drive preparative workflows and define final product quality.
  • 3+ years of people management experience leading a team.
  • Excellent communication, attention to detail, documentation and technical writing skills.
  • Align with manufacturability from a purification perspective (e.g. resins, wash steps, flow though/weak partitioning, formulating).
Responsibilities
  • Guides rigorous data analysis, interpretation, and communication by monitoring and conducting complex data analysis and interpretation and ensuring high quality and reliability of data across multiple experimental data sets and projects.
  • Interpret complex data and providing guidance on troubleshooting challenging issues with the experiment; and leading the implementation of new digital tools or strategies.
  • Builds, coaches, and mentors a team of high-performing scientists by identifying and recommending new approaches and improvements that can be incorporated into development plans.
  • Lead and facilitate discussions with cross-functional teams on own lab or project team's work to drive success of multiple projects.
  • Guide multi-step protein purifications of various protein modalities leveraging different affinity tags, secondary chromatography and polishing steps on AKTA systems.
  • Assess protein quality metrics for all proteins produced within team.
  • Explore, assess, and bring in-house state of the art technologies to enhance and continuously improve efficiencies across internal platforms.
  • Manage all protein purification activities in group being accountable for planning, prioritization, and on-time delivery of generated protein variants.
  • Efficiently accomplish project goals on time and budget, tracking capacity constraints and resource use within team.
  • Collaborate and coordinate with upstream DNA and protein expression teams.
  • Encourage and help coordinate cross-training of sub-disciplines when appropriate.
  • Serve as a subject matter expert in recombinant protein production to different cross-functional teams.
  • Detailed documentation of experiments and data on our internal LIMS systems, electronic notebook and presentations to project teams.
  • Drive discussions with downstream stable CHO production groups for manufacturability.
  • Program leadership in the form of departmental representation.
Generate Biomedicines

Generate Biomedicines

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Generate Biomedicines focuses on creating new medicines using a method called generative biology, which combines machine learning and biological engineering. This approach involves analyzing millions of proteins to learn how nature encodes their functions, allowing the company to design new medicines with specific therapeutic effects. The main product, The Generate Platform, enables the rapid production of medicines across various therapeutic areas, significantly improving the drug discovery process compared to traditional methods. Unlike its competitors, Generate Biomedicines emphasizes a proactive and efficient approach to medicine creation, aiming to democratize access to biotherapeutics. The company's goal is to expand its capabilities in generating and testing proteins, having already produced 42,000 proteins, and to continue advancing the field of therapeutics.

Company Stage

Series C

Total Funding

$693M

Headquarters

Somerville, Massachusetts

Founded

2018

Growth & Insights
Headcount

6 month growth

5%

1 year growth

15%

2 year growth

44%
Simplify Jobs

Simplify's Take

What believers are saying

  • The recent $273M Series C financing round provides substantial capital to advance their generative AI pipeline and clinical programs.
  • Expansion of the leadership team with experienced professionals like Rupert Vessey, Nancy Simonian, and Kym White strengthens the company's strategic direction and operational capabilities.
  • Publication of the Chroma model in Nature highlights the company's innovative contributions to protein therapeutics, enhancing its reputation in the scientific community.

What critics are saying

  • The reliance on cutting-edge generative AI and machine learning technologies may face regulatory and adoption challenges in the conservative pharmaceutical industry.
  • Rapid expansion and scaling efforts, including new hires and leadership changes, could lead to integration and cultural challenges.

What makes Generate Biomedicines unique

  • Generate Biomedicines leverages generative biology and machine learning to create medicines on demand, a significant departure from traditional drug discovery methods.
  • The Generate Platform's ability to produce novel medicines across multiple therapeutic areas with high speed and success rates sets it apart from competitors.
  • Their focus on understanding the rules by which nature encodes function to design new proteins is a unique approach in the biotechnology sector.