Full-Time

Principal Scientist

Medicinal Chemistry

Confirmed live in the last 24 hours

Flagship Pioneering

Flagship Pioneering

201-500 employees

Biotechnology firm creating health and sustainability solutions

Biotechnology
Healthcare

Expert

Cambridge, MA, USA

Category
Biology Lab & Research
Biology & Biotech
Requirements
  • Ph.D. in Organic Chemistry or Medicinal Chemistry with a minimum of 10+ years of relevant drug discovery experience in the biotech/pharmaceutical industry
  • Experienced in all aspects of medicinal chemistry including use of tool/probe compounds, hit ID and follow-up, hit-to-lead chemistry, and lead optimization to candidate selection
  • Broad background in all aspects of drug discovery, including SBDD, physicochemical property-driven optimization (MPO) and computational chemistry
  • Working knowledge of structural biology, ADME/PK, in vitro assays, and in vivo pharmacology
  • Experience in managing and building strong relationships with chemistry CROs
  • Demonstrated success in leading medicinal chemistry and projects teams to deliver high quality compounds into development
  • Experience in oligonucleotide drug discovery is a plus
  • Track record of delivering on project and company goals
  • Ability to accommodate to rapidly changing priorities and deadlines
  • Excellent communication and project leadership skills and ability to work effectively in a cross-functional team setting
  • Proven track record for striving for a high level of innovation and scientific excellence
Responsibilities
  • Discover and advance novel chemical entities (small molecules, protacs, molecular glues) into clinical development
  • Define, implement, and execute on medicinal chemistry strategies from hit ID to lead generation, lead optimization and candidate selection
  • Provide strategic, scientific, and managerial leadership to external CRO med chem teams
  • Serve as project and chemistry lead for drug discovery programs
  • Collaborate with the IP team to create and execute strategy to establish, protect and expand intellectual property
  • Communicate, collaborate, and coordinate effectively within cross-functional teams
  • Effectively present and communicate research findings at internal meetings and external scientific conferences

Flagship Pioneering fosters a culture of groundbreaking advancements in biotechnology, emphasizing an ecosystem approach that synergizes human health and sustainability. Their business model not only focuses on creating transformative products but also incubates leading companies like Moderna and Indigo Agriculture, positioning them at the forefront of scientific innovation and industry leadership. This approach offers employees a unique opportunity to be part of a pioneering team that drives real-world impacts across multiple sectors.

Company Stage

N/A

Total Funding

$10.2B

Headquarters

Cambridge, Massachusetts

Founded

2000

Simplify Jobs

Simplify's Take

What believers are saying

  • Flagship's recent $3.6 billion raise will support the creation of 25 new breakthrough companies, offering substantial growth opportunities.
  • The firm's track record of founding over 100 biotechnology companies, including industry leaders like Moderna, highlights its potential for high-impact innovation.
  • Key leadership appointments and promotions, such as Lovisa Afzelius to General Partner, strengthen Flagship's strategic direction and operational capabilities.

What critics are saying

  • The ambitious goal of creating 25 breakthrough companies may stretch resources and focus, potentially impacting the quality of each venture.
  • Heavy reliance on AI and advanced computational techniques could face technological and regulatory hurdles, slowing down progress.

What makes Flagship Pioneering unique

  • Flagship Pioneering's focus on creating and developing breakthrough companies in human health, sustainability, and AI sets it apart from traditional venture firms.
  • Their significant capital pool of $10.9 billion and $14 billion in assets under management provides unparalleled financial backing for innovative ventures.
  • Flagship's unique approach to leveraging generative AI for drug discovery and development accelerates the creation of transformative technologies.

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