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Guidehouse

Advises agencies and runs regulated operations

Staff Scientist

Life Sciences ResearchPosted on Nov 11
Full-timeBethesda, MD, USA

About the Job

Requirements

  • A PhD or MD in human genetics, molecular biology, biochemistry, immunology, or a closely related field is required.
  • At least five years of postdoctoral research experience in translational research, genetics or genomics, immunology, and/or molecular biology is required.
  • Multiple first-author publications in peer-reviewed journals are required.
  • Hands-on experience working with murine models, specifically transgenic mice, is required.
  • Experience in hematology, vascular biology, red blood cell health, and/or related fields such as nephrology is required.
  • Proficiency in tissue culture, biochemistry and molecular biology assays, gene expression analysis, and/or processing patient biosamples is required.
  • Experience with bioinformatics, statistical interpretation, and managing interdisciplinary research projects is required.
  • Must be able to obtain and maintain a Federal or Department of Defense Public Trust; approved adjudication is required before onboarding.

Responsibilities

  • Investigate genetic modifiers and biological mechanisms influencing disease severity and clinical outcomes.
  • Apply cellular biology, molecular biology, immunology, and bioinformatics methods to study red blood cell dysfunction, acute pain, and inflammation.
  • Identify and evaluate biomarkers for monitoring disease processes and treatment response.
  • Conduct preclinical studies using animal models, primarily mice, to assess disease mechanisms and investigational therapies.
  • Integrate genotype–phenotype analyses with clinical, laboratory, imaging, and diagnostic data to characterize disease manifestations and identify therapeutic targets.
  • Evaluate drugs and experimental compounds in preclinical and clinical research to reduce hemoglobin polymerization, improve red blood cell flexibility and flow properties, or increase fetal hemoglobin production.

Desired Qualifications

  • Strong written and verbal communication, organizational, and time-management skills.
  • Detail-oriented work approach.
  • Ability to work independently and collaboratively as a team member.
  • Experience training, teaching, and mentoring junior research staff, graduate students, and postdoctoral fellows is strongly preferred.
  • Strong evidence of independent scientific leadership, publications, and collaboration management.

About the Company

Guidehouse

Advises agencies and runs regulated operations

Guidehouse advises government agencies and companies in regulated industries on strategy, technology and day-to-day operations. Its work combines business advice with software implementation and ongoing management, so a client uses the same firm to plan a change, build the systems and run the resulting processes. Teams modernize cloud platforms, apply data analysis and artificial intelligence, and redesign organizations to meet operating and regulatory requirements. Clients pay for consulting projects and technology work or outsource continuing business functions to its managed services teams. Guidehouse was founded in 2018 and is headquartered in McLean, Virginia.

Company size
10,001+
Company stage
Acquired
Total funding
$750K
Headquarters
McLean, VA
Founded
2018

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