S

Soleno Therapeutics

Clinical-stage biopharma developing rare-disease therapies

Rare Disease Specialist

Full-TimeUpdated on 10/22/2026
$190k - $210k
Senior
Bachelor's
Remote in USA
RemoteRemote role covering Wisconsin, Iowa, and eastern Nebraska, including Omaha and Lincoln; travel 60%.
Sales & Account ManagementField Sales

About the job

Requirements
  • A bachelor's degree is required; an advanced degree is preferred.
  • At least 5-7 years of pharmaceutical-industry experience with a proven sales track record is required.
  • A demonstrated compassionate approach to patient care and provider awareness, and a drive to serve the Prader-Willi syndrome community, are required.
  • Ability to work and thrive in a fast-paced startup environment is required.
  • Strong analytical, communication, and influence skills are required.
  • Ability to travel 60% of the time is required.
Responsibilities
  • Engage a well-defined pool of caregivers and medical specialists to build market development, raise brand awareness, and execute a territory strategy/account plan to support product success through launch and beyond.
  • Develop a territory strategy focused on nurturing existing relationships and raising awareness.
  • Conduct regular field visits to ensure effective communication and address issues that arise.
  • Engage providers and drive awareness across multiple points of call, including specialists in neurology, endocrinology, and psychiatry.
  • Help ensure new and existing patients are identified and enrolled in treatment programs.
  • Segment clinics and identify key shareholders within target institutions.
  • Build and maintain strong relationships with healthcare professionals, office staff, caregivers, and families; gather insights and conduct post-call analysis to refine tactics based on territory challenges and rare-disease market dynamics.
  • Adapt communication styles to the needs of healthcare professionals and advocacy groups within the Prader-Willi syndrome community.
  • Monitor and report territory-level market dynamics and trends, including prescriber opinion, competitive activity, and developments in the Prader-Willi syndrome landscape.
  • Report sales activities, performance metrics, and competitive insights to sales management.
  • Foster effective working relationships with internal and external stakeholders and drive agreement and decisions from multiple parties.
  • Collaborate across commercial departments, including Patient Services and Medical Affairs, to align with external stakeholders in the rare-disease space.
  • Participate in developing sales strategies to meet quarterly and annual targets by tailoring tactics to territory challenges.
  • Prioritize and manage time, activities, and resources to engage with a network of healthcare professionals specializing in rare diseases.
  • Ensure compliance with company policies and industry regulations during sales activities.
  • Maintain a positive and collaborative culture aligned with the sales organization.
  • Maintain up-to-date knowledge of Prader-Willi syndrome and the healthcare landscape to support customer needs.
Desired Qualifications
  • A background in nursing, social work, or nutrition as a registered dietitian, with rare-disease experience, is a plus.
  • Previous product-launch experience is highly preferred.
  • Prior experience in rare genetic disease or specialty sales is highly preferred.
  • A compliance and regulatory training background is preferred.
  • Experience in pediatric endocrinology or diabetes is highly preferred.

About the company

Soleno Therapeutics develops and commercializes treatments for rare diseases, with a focus on Prader-Willi syndrome (PWS) and other rare endocrine disorders. Its lead product, DCCR (Diazoxide Choline Extended Release) tablets, is an oral once-daily medicine designed for its target conditions; the exact biological mechanism is not detailed in the provided information. The company differentiates itself by concentrating on a narrow, underserved niche in biopharma and pursuing regulatory designations like Orphan Drug and FDA Fast Track to help bring treatments to market. Soleno’s goal is to advance its research pipeline and obtain regulatory approval to deliver therapies that can improve outcomes for patients and families affected by rare endocrine disorders.

Company Size

51-200

Company Stage

IPO

Headquarters

Redwood City, California

Founded

1999

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Simplify's Take

What believers are saying

  • Neurocrine paid $53 per share, validating Soleno’s commercial asset in April 2026.
  • Second-quarter 2026 VYKAT XR sales reached $54 million after the May 18 closing.
  • June 15, 2026 ENDO data showed durable two-year hyperphagia and behavior improvements.

What critics are saying

  • Neurocrine completed Soleno’s acquisition on May 18, 2026, eliminating standalone Soleno roles.
  • March 2026 securities litigation alleges concealed fluid-retention and safety problems from DCCR trials.
  • PWS concentration leaves VYKAT XR vulnerable if adverse-event reports trigger FDA label restrictions.

What makes Soleno Therapeutics unique

  • VYKAT XR became the first FDA-approved PWS hyperphagia therapy on March 26, 2025.
  • Soleno built a rare-disease franchise around one defined indication and one oral product.
  • Mid-2040s intellectual property gave Neurocrine a long commercialization runway for VYKAT XR.

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Growth & Insights and Company News

Headcount

6 month growth

10%

1 year growth

10%

2 year growth

11%
U.S. Securities and Exchange Commission
Sep 20th, 2026
8-K

Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

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Sangamon Sun
Jun 15th, 2026
Soleno Therapeutics presents data on VYKAT XR for Prader-Willi syndrome at ENDO 2026.

Soleno Therapeutics presents data on VYKAT XR for Prader-Willi syndrome at ENDO 2026. Soleno Therapeutics, a Neurocrine Biosciences company, announced on June 15 new late-breaking data at ENDO 2026 showing that resuming treatment with VYKAT XR (diazoxide choline) extended-release tablets for two years after a 16-week randomized withdrawal period was associated with durable improvements in hyperphagia and behavioral symptoms in individuals with Prader-Willi syndrome. Sanjay Keswani, M.D., Chief Medical Officer of Neurocrine Biosciences, said, "These compelling data further reinforce our confidence in VYKAT XR as a safe and effective long-term treatment for hyperphagia in individuals four years of age and older living with Prader-Willi syndrome. Individuals who resumed treatment following the randomized withdrawal period achieved durable improvements in hyperphagia and other PWS-related behaviors. This completes the presentation of data from our comprehensive Phase 3 development program and further confirms the long-term benefit of VYKAT XR for people living with PWS." The Phase 3 development program included Study C614, an open-label long-term extension study enrolling 77 participants. The study assessed whether those who had received placebo during the withdrawal period could regain benefit after restarting VYKAT XR and whether those who remained on continuous therapy maintained improvement over time. Hyperphagia was measured using the Hyperphagia Questionnaire for Clinical Trials (HQ-CT), while behavioral symptoms were assessed by the PWS Profile questionnaire (PWSP). Results showed that participants resuming VYKAT XR experienced recovery of benefit, while those continuing therapy maintained improvements. Additional presentations compared outcomes from VYKAT XR-treated participants to natural history controls from the PATH for PWS Natural History Study. Over three years, statistically significant and sustained improvements were observed in hyperphagia scores at all evaluated time points (p<0.0001), with consistent benefits also reported across six behavioral domains such as anxiety, rigidity/irritability, compulsivity, aggressive behaviors, disordered thinking, and depression. Prader-Willi syndrome is described as a rare genetic neurodevelopmental disorder caused by abnormal gene expression on chromosome 15. The main symptom is hyperphagia - a persistent sensation of hunger leading to food preoccupations - which can severely affect quality of life and lead to additional health complications including diabetes or cardiovascular disease. VYKAT XR was approved by the U.S. Food and Drug Administration on March 26, 2025, for treating hyperphagia in adults and pediatric patients aged four years or older with Prader-Willi syndrome. Important safety information includes contraindications related to hypersensitivity to diazoxide or thiazides; warnings about risks such as hyperglycemia or fluid overload; monitoring recommendations; and common adverse reactions like hypertrichosis or edema.

Gulf & Main Magazine
Apr 6th, 2026
Neurocrine acquires Soleno for $2.9B, adding first FDA-approved PWS hyperphagia treatment VYKAT XR

Neurocrine Biosciences has agreed to acquire Soleno Therapeutics for $53 per share in cash, representing a total equity value of $2.9 billion. The deal adds VYKAT XR, the first FDA-approved treatment for hyperphagia in Prader-Willi syndrome, to Neurocrine's portfolio. VYKAT XR launched in the second quarter of 2025 and generated $190 million in revenue during its first year, including $92 million in the fourth quarter. The acquisition expands Neurocrine's commercial portfolio to three first-in-class medicines and establishes a platform for long-term growth, supported by intellectual property extending into the mid-2040s. The deal, approved by both boards, will be funded with cash and modest debt. The transaction is expected to close within 90 days, subject to regulatory approvals and customary conditions.

MarketScreener
Apr 6th, 2026
Neurocrine to Acquire Soleno Therapeutics, Expanding Its Endocrinology and Rare Disease Portfolio

(Nasdaq: NBIX) and Soleno Therapeutics, Inc. (Nasdaq: SLNO) today announced that Neurocrine has entered into a definitive agreement to acquire Soleno for $53.00 per share in cash, representing a total transaction equity value of $2.9 billion.