Full-Time

Principal Engineer

Applications Fellowship

Weave

Weave

51-200 employees

Generative AI platform for life-science collaboration

No salary listed

Remote in USA + 1 more

More locations: Lehi, UT, USA

Remote

Category
Software Engineering (1)
Required Skills
Kubernetes
Python
Machine Learning
Apache Kafka
Java
Postgres
Infrastructure as Code (IaC)
C#
AWS
Go
Redis
Observability
Google Cloud Platform

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Requirements
  • 15+ years of software engineering experience with progressive technical leadership scope.
  • A track record of leading cross-team technical initiatives that delivered measurable business outcomes.
  • The ability to influence without authority, build consensus across organizational boundaries, and translate technical tradeoffs into business terms.
  • Deep expertise in distributed systems architecture, including building and operating services that handle hundreds of millions of transactions and terabytes of data.
  • Proven experience with event streaming and messaging infrastructure such as Kafka or Google Pub/Sub at significant scale.
  • A strong background in scalable relational data stores including PostgreSQL at scale, Vitess, and Spanner, as well as NoSQL data stores including Bigtable and Redis.
  • Operational experience with cloud-native infrastructure on Google Cloud Platform or Amazon Web Services, including Kubernetes, infrastructure as code, and highly available system design.
  • A solid backend engineering foundation; Go is preferred, while Python, Java, or C# are acceptable.
Responsibilities
  • Own the multi-year technical vision for Payments, Scheduling, Forms, Business Experience, and Revenue Cycle Management application platforms.
  • Drive architectural coherence across multiple teams by identifying and resolving cross-system dependencies and platform-level technical debt.
  • Lead technical due diligence for major initiatives, including build-versus-buy decisions, vendor evaluations, and platform migrations.
  • Identify and solve company-level technical problems spanning organizational boundaries.
  • Compile information across systems, teams, and projects to develop comprehensive solutions with validation, rollback, and testing plans.
  • Forecast project costs in time, money, and opportunity cost, accounting for impacts across the business.
  • Monitor the industry landscape and anticipate the direction of high-scale customer experience and transactional platforms.
  • Identify strategic value in emerging technologies and lead initiatives that prepare the company for emerging challenges.
  • Shape company-wide standards for engineering excellence, observability, and reliability in distributed systems.
  • Mentor Staff and Senior Engineers across the fellowship.
  • Elevate architectural thinking through design reviews, documentation standards, and hands-on guidance.
  • Build organizational technical capability that persists beyond individual contributions.
Desired Qualifications
  • Background in compliance-heavy environments such as healthcare or fintech, with experience navigating regulatory requirements in technical design.
  • Experience shaping artificial intelligence and machine learning infrastructure or integrating artificial intelligence capabilities into production systems.
  • External technical leadership through open-source contributions, conference speaking, or published technical writing.
  • Expertise in data platform architecture, including streaming pipelines, data lakes, warehouses, or distributed analytics.

Weave.bio provides a platform for life sciences collaboration by integrating a generative AI system with a knowledge graph to connect researchers, data, and projects. The platform generates insights and maps connections across datasets, research teams, and workflows, while an incentive system rewards contributors proportionally to the value they add. Unlike tools that focus on a single function, Weave.bio combines collaboration features with a data-linking graph and an explicit rewards model to reduce silos and encourage sharing. The goal is to accelerate biomedical research and development, helping pharma, biotech, and academic researchers move from discovery toward real-world impact faster.

Company Size

51-200

Company Stage

Series A

Total Funding

$31.6M

Headquarters

New Haven, Connecticut

Founded

2023

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Simplify Jobs

Simplify's Take

What believers are saying

  • Weave raised $20 million Series A in October 2025 from USVP and Innovation Endeavors.
  • By April 2026, Weave had roughly two dozen customers and three approved FDA submissions.
  • Named customers and partners include Parexel, Takeda-linked workflows, and top 20 pharma buyers.

What critics are saying

  • Veeva Submissions and Veeva RIM dominate entrenched regulatory workflows across global pharma.
  • If FDA approvals slow, Weave's early customer proof collapses before enterprise expansion.
  • A product failure on submissions or compliance would damage trust and stall adoption.

What makes Weave unique

  • Weave Bio covers IND through NDA, and now global submissions, by April 2026.
  • Parexel partnership gives Weave exclusive CRO access to co-developed NDA templates.
  • Its AI-native platform embeds drafting, review, verification, and publishing in one workflow.

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Benefits

Remote Work Options

Professional Development Budget

Growth & Insights and Company News

Headcount

6 month growth

-8%

1 year growth

-8%

2 year growth

-16%
Associated Press
Jun 15th, 2026
Weave Bio launches AI-powered global drug submission platform from single source of truth

Weave Bio, an AI-powered regulatory automation platform for drug development, has launched global submission capabilities allowing pharmaceutical teams to manage all regulatory filings from a single source of truth. The new features enable companies to use one verified reference set across multiple jurisdictions, from initial Investigational New Drug applications through to final approval. The platform includes a pre-loaded EU Clinical Trial Application template compliant with European Medicines Agency standards, plus a custom template builder for other jurisdictions. This eliminates the traditional need to rebuild dossiers from scratch for each new market. Founded in 2022 and based in San Francisco, Weave Bio is backed by investors including USVP, Innovation Endeavors and Magnetic Ventures. The company will demonstrate the new capabilities at the DIA 2026 Annual Meeting in Philadelphia.

PR Newswire
Jun 2nd, 2026
Syner-G launches 3D Intelligence (3Di(TM), a people-centered AI transformation service for biopharma.

Syner-G launches 3D Intelligence (3Di(TM), a people-centered AI transformation service for biopharma. Jun 02, 2026, 09:55 ET Syner-G launches 3D Intelligence (3Di(TM), an enterprise AI transformation service for biopharma that combines human-centered strategy, regulatory expertise, and scalable implementation to move organizations from fragmented AI pilots to measurable, enterprise-wide impact. BOSTON, June 2, 2026 /PRNewswire-PRWeb/ - Syner-G, a Strategic Development & Delivery Partner(TM) to biopharma innovators, today announced the official launch of 3D Intelligence (3Di(TM), an enterprise AI transformation service designed to move organizations from fragmented experimentation to scaled, measurable impact. Designed for regulated environments, 3Di applies a human-centered, strategy-led approach to deliver fit-for-purpose AI solutions that scale while preserving human judgment. The approach reflects key principles from FDA and EMA guidance, emphasizing human ownership in work design and decision-making, alongside risk-based practices, transparency, and disciplined lifecycle and data management. Since October 2025, Syner-G has piloted 3Di with sponsor organizations across product development, portfolio management, and regulatory authoring, alongside an internal transformation of its own Medical Writing business. As part of this internal effort, Syner-G has partnered with Weave Bio as its technology provider for AI-augmented authoring and knowledge management across the IND-to-NDA lifecycle. Early results demonstrate significant reductions in authoring time across a range of submission documents, without compromising quality or accuracy. Full pilot data to be published within the coming months. "Partnering with Syner-G shows how AI delivers real, measurable impact when it's implemented in a human-centered framework," said Brandon Rice, CEO of Weave Bio. "Together, we're driving measurable gains in speed, quality, and consistency for sponsors, while ensuring the technology strengthens the expertise behind it." "The real opportunity with AI isn't replacing work - it's elevating it," said Jennifer Kilroy, PhD, MBA, SVP of Strategy and Transformation at Syner-G. "But that only happens when organizations lead with empathy, are committed to building real trust, and stay anchored in the problems that are worth solving. As one of our AI advisors says, organizations must move at the speed of trust - and that's not a technology challenge, it's a human one. With 3Di, we're helping companies prepare their people, systems, and businesses to do exactly that." Rethinking the starting point for successful AI adoption While adoption is accelerating across biopharma, many organizations remain constrained by fragmented pilots, unclear governance, integration gaps, and low workforce adoption. 3Di addresses this by aligning AI initiatives to business and scientific priorities, focusing on high-impact use cases, and building the foundations needed to scale by integrating best practices in digital transformation, business excellence, and organizational change management. "3Di was built to help life sciences leaders answer the fundamental question every organization is facing: how do we apply AI in meaningful, scalable ways," said Ron Kraus, CEO of Syner-G. "By combining deep domain expertise, practical business cases, and human-centered AI implementation, we help clients identify high-impact opportunities, reduce execution risk, and deliver measurable outcomes across the drug development continuum. Our collaboration with Weave demonstrates how the right combination of AI capabilities and domain expertise can accelerate execution, improve decision-making, and ultimately help bring therapies to patients more efficiently." Upcoming engagements * June 10, 2026 (Virtual) - American Medical Writer's Association (AMWA) Webinar: "The Future of Medical Writing: Applying AI Through a Human-Centric Lens," 1-2 PM ET * June 22-25, 2026 (San Diego) - BIO International Convention: California Pavilion alongside Biocom and CLSA, Booth #1525 * June 23, 2026 (San Diego) - BLPN BIO Week Summit: Jennifer Kilroy, PhD, MBA to speak alongside leaders from Connect and AAIH on AI's role in transforming healthcare delivery * October 28, 2026 (Boston) - AI in Drug Discovery (AIDD) Summit: Syner-G to host a panel on advancing AI deployment in process development and manufacturing About Syner-G Syner-G is a Strategic Development & Delivery Partner(TM) to biopharma innovators, bringing together integrated scientific, regulatory, technical, and transformation consulting expertise across the development lifecycle. With more than 400 professionals across North America, Europe, and APAC, Syner-G collaborates closely with clients to reduce risk, accelerate development, and navigate the complexity of bringing therapies to market. Media Contact Lyndsey Brumbach, Syner-G, 1 909-921-2824, [email protected], synergbiopharma.com SOURCE Syner-G

Business Wire
Apr 29th, 2026
Weave Bio launches AI-powered NDA workflow with Parexel, cutting authoring time by 60%

Weave Bio has launched New Drug Application (NDA) workflow support on its AI-native regulatory automation platform, developed in partnership with Parexel. The platform now covers the full regulatory lifecycle for drug development. Through Parexel's real-world use of the platform for NDA submissions, Weave has delivered authoring timelines more than 60% faster than traditional methods. The platform uses AI-native data extraction, document authoring, content verification and workflow automation to streamline the NDA preparation process. Parexel, which brings over 40 years of regulatory experience, served as a strategic design partner and will maintain exclusive access as the only contract research organisation using the co-developed templates. Founded in 2022 and based in San Francisco, Weave Bio is backed by investors including USVP and Innovation Endeavors.

Business Wire
Mar 25th, 2026
Weave Bio forms strategic advisory board to guide AI-driven regulatory science evolution

Weave Bio, an AI-driven regulatory automation company, has established its inaugural Strategic Advisory Board to guide the development of its platform and advance AI adoption in life sciences regulation. The board comprises senior executives from pharmaceutical companies and academia, including leaders from Takeda, Boehringer Ingelheim, Gilead, Stanford University and Serrado Capital. The SAB formation follows significant momentum for the San Francisco-based startup, which raised $20 million in Series A funding in October 2025 and announced a strategic partnership with Parexel. Weave Bio's platform streamlines regulatory content preparation for pharmaceutical companies, reducing regulatory timelines by over 50 percent whilst maintaining FDA and EMA compliance standards. Founded in 2022, Weave Bio has raised backing from investors including USVP, Innovation Endeavors and Magnetic Ventures.

Business Wire
Oct 18th, 2025
Weave Bio Secures $20M Series A Funding to Enhance Its AI-Native Regulatory Platform

Weave Bio raises $20M Series A to expand its AI-native platform that accelerates regulatory workflows for drug development.