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Rhythm Pharmaceuticals

Commercializes MC4R-targeted therapies for rare obesity

Executive Medical Director

Biology & BiotechConfirmed live in the last 24 hours
Full-timeBoston, MA, USA

About the Job

Requirements

  • A Doctor of Medicine (MD) or equivalent international medical degree is required.
  • A minimum of 8–10 years of clinical development experience within the pharmaceutical or biotechnology industry, including experience leading global clinical development programs and regulatory interactions.
  • Demonstrated success serving as a senior medical leader within a Clinical Development organization, including mentoring and developing other physicians and providing technical leadership across multiple studies or programs.
  • A demonstrated track record of successful clinical trial design, medical oversight, and execution across Phase 1 through Phase 3 clinical studies, including registrational or pivotal trials.
  • Proven experience leading clinical components of global regulatory filings (IND/NDA/BLA/MAA) and participating directly in formal interactions with regulatory agencies (e.g., FDA, EMA, PMDA).
  • Deep expertise in GCP/ICH guidelines, pharmacovigilance reporting standards, ethical conduct of clinical trials, and global clinical regulatory policies.
  • Demonstrated success influencing cross-functional teams and external stakeholders and serving as a trusted subject matter expert and mentor within a Clinical Development organization.
  • Demonstrated ability to balance scientific rigor, patient needs, regulatory requirements, and business priorities within a fast-paced biotech environment.
  • Superior written, verbal, and presentation communication skills, with the ability to convey complex medical and scientific concepts clearly to diverse internal and external audiences.
  • Ability to travel domestically and internationally as necessary, up to 20%.
  • Candidates must be willing and able to work in the Boston office in coordination with their department and business needs.

Responsibilities

  • Serve as the Clinical or Medical Lead across multiple complex clinical studies and development programs, ensuring high-quality trial execution, patient safety, and scientific integrity.
  • Act as a senior clinical development resource within the organization, providing scientific and operational guidance to fellow Medical Directors and study teams.
  • Lead the creation, optimization, and execution of comprehensive Clinical Development Plans and innovative study protocols for new indications, lifecycle management activities, and future pipeline opportunities.
  • Provide strategic medical and scientific leadership across cross-functional matrix teams, including Clinical Operations, Biostatistics, Data Management, Regulatory Affairs, Medical Affairs, Translational Research, and Drug Safety or Pharmacovigilance.
  • Provide physician oversight for medical monitoring activities, including subject eligibility evaluation, protocol deviations, endpoint assessment, and emerging clinical issues.
  • Provide clinical safety leadership across assigned programs, including review of aggregate safety data, serious adverse event evaluation, benefit-risk evaluation, and collaboration with Pharmacovigilance to support patient safety.
  • Lead the clinical authoring, review, and defense of key regulatory documents, including INDs, Briefing Packages, Investigator’s Brochures, Clinical Study Reports, and NDA/BLA/MAA clinical modules; serve as a primary clinical representative in meetings with the FDA, EMA, and other global health authorities.
  • Direct interpretation, synthesis, and reporting of complex clinical data from ongoing and completed trials, contributing to peer-reviewed publications, congress presentations, and internal executive briefings.
  • Provide leadership in interpreting complex clinical data and support less-experienced team members in developing data interpretation and communication skills.
  • Establish and maintain collaborative partnerships with external Key Opinion Leaders, investigators, academic collaborators, and study sites; support and participate in Scientific Advisory Boards and Data Safety Monitoring Boards.
  • Mentor, guide, and support Medical Directors and cross-functional study team members, sharing clinical development expertise and serving as a resource for protocol design, medical monitoring, regulatory strategy, and study execution.
  • Help strengthen organizational capabilities through knowledge sharing, best practices, and informal leadership across the Clinical Development function.

Desired Qualifications

  • Board certification in Endocrinology, Pediatrics, Genetics, Internal Medicine, or a related specialty is preferred.
  • Experience in rare disease, endocrinology, obesity, metabolic disease, pediatrics, or related therapeutic areas is strongly preferred.

About the Company

Rhythm Pharmaceuticals

Commercializes MC4R-targeted therapies for rare obesity

Rhythm Pharmaceuticals focuses on developing therapies for rare neuroendocrine genetic obesity disorders, led by IMCIVREE (setmelanotide). IMCIVREE is an MC4R agonist that restores signaling in the MC4R pathway to curb hunger and regulate energy use; it is FDA, EC, and MHRA approved for Bardet-Biedl syndrome and certain POMC/PCSK1/LEPR deficiencies in patients aged 2 and older, with revenue from global sales. The company differentiates itself by pursuing precision medicine for MC4R pathway diseases and advancing additional MC4R programs like bivamelagon and RM-718. Rhythm’s goal is to broaden access to MC4R-targeted therapies for rare patient populations and grow its pipeline toward sustainable commercialization.

Company size
501-1,000
Company stage
IPO
Headquarters
Boston, MA
Founded
2008

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