Scientist to Senior Scientist - Discovery Research

工作地点 | Location ：

广州 Guangzhou

岗位职责 | Position responsibilities and duties：

• 负责创新抗体发现项目的设计与执行，覆盖从动物免疫到候选抗体筛选/确认的完整流程。
• 推动传统抗体发现路径的交付，包括：动物免疫策略设计与优化（如小鼠）、杂交瘤构建/筛选/克隆化，以及抗体功能筛选（如ELISA、细胞功能实验等）。
• 建立并应用新一代单B细胞抗体发现平台流程，包括单B分选（如微流控或高通量系统）、样本制备（脾细胞制备、浆B细胞富集等）、单细胞筛选/回收与下游流程衔接。
• 构建并持续优化高通量抗体发现pipeline，以提升筛选效率、命中率与多样性，并确保流程可重复、可规模化。
• 支持抗体序列获取与分析，包括单细胞RT‑PCR、VH/VL扩增与测序，使用生信软件完成候选序列优选与命中列表产出。
• 作为技术骨干/项目owner，指导初级同事，推动团队能力建设与方法学沉淀。
• 评估与整合新兴技术（例如单B细胞与杂交瘤策略的组合与取舍），制定抗体发现策略并支持项目关键节点决策。
• （资深岗强调）建立/维护关键SOP与QC检查点（免疫、杂交瘤、单B上机与回收、序列获取等），并以数据质量与交付物为导向输出可追溯的实验记录与总结报告。
• （资深岗强调）支持平台稳定运行相关工作（培训、关键耗材规划、供应商/设备沟通），保障筛选通量与数据一致性（如Hypercell单B高通量平台/相关系统）。
• 根据项目和业务需求，完成上级安排的其他相关工作。
• Lead the design and execution of innovative antibody discovery projects, covering the full workflow from immunization to candidate selection.
• Drive antibody discovery using conventional approaches, including: design and optimization of animal immunization strategies (e.g., mouse), hybridoma generation/screening/cloning, and antibody functional screening (ELISA, cell-based assays, etc.).
• Establish and implement next-generation single B cell-based antibody discovery workflows, including single B cell sorting (e.g., microfluidics or high-throughput systems), sample preparation (splenocyte preparation, plasma B cell enrichment, etc.), single-cell screening/recovery, and downstream workflow integration.
• Build and optimize high-throughput antibody discovery pipelines to improve efficiency, hit rate, and diversity, with a focus on robustness and reproducibility.
• Support antibody sequence generation and analysis, including single-cell RT-PCR, VH/VL amplification and sequencing, and utilizing bioinformatic tools for candidate selection and hit list generation.
• Act as a technical lead or project owner, mentoring junior scientists and driving team capability building.
• Evaluate and integrate emerging technologies (e.g., single B cell vs hybridoma strategies) and help define antibody discovery strategies for key project milestones.
• (Senior scope) Develop, document, and maintain SOPs and QC checkpoints across immunization, hybridoma, and single B cell workflows; deliver traceable records, data packages, and technical summaries.
• (Senior scope) Support platform operational readiness (training, key consumables planning, and vendor/equipment interfacing) to ensure stable throughput and data consistency for high-throughput single-cell screening platforms (e.g., Hypercell or similar systems).
• Perform other duties as assigned, in alignment with project and business needs.

任职资格/Qualifications:

教育背景 | Education

• 博士优先：免疫学、生物学、药学或相关领域博士；亦可考虑硕士学历但具有丰富相关经验者。
• PhD. preferred/required in Immunology, Biology, Pharmacy, or related field (Master’s with extensive experience may be considered).

工作经验 | Experience

• Scientist：博士 ≥3年（或硕士 ≥ 6-8年）抗体发现/筛选相关经验。
• Senior Scientist：博士 ≥6年（或硕士 ≥ 9年）抗体发现与/或平台流程建设经验。
• 特别优秀者可适当放宽年限（以项目深度与实际交付为准）。
• Scientist: Ph.D. with ≥3 years (or M.S. with ≥ 6-8 years) of relevant antibody discovery experience.
• Senior Scientist: Ph.D. with ≥6 years (or M.S. with ≥ 9 years) of relevant antibody discovery and/or platform development experience.
• Exceptional candidates may be considered with flexibility on years of experience (based on project depth and deliverables).

专业技能 | Technical Skills

必须具备 | Required

• 扎实的抗体发现动手经验：动物免疫策略设计与执行；杂交瘤抗体制备与筛选。
• 深入理解并能熟练应用抗体筛选/功能验证方法：ELISA、流式细胞术、细胞功能实验等。
• Strong hands-on experience in antibody discovery, including animal immunization strategy design/execution and hybridoma-based antibody generation/screening.
• Deep understanding of antibody screening and functional assays: ELISA, flow cytometry, and cell-based assays.

加分项 | Preferred

• 单B细胞抗体发现经验：单细胞分选（微流控/FACS）、单细胞VH/VL获取与测序。
• 有高通量抗体发现平台经验（如Hypercell或类似系统）及相关工作流理解。
• 额外优势：NGS数据分析、抗体工程（人源化、亲和力成熟）、双抗/多抗经验。
• Experience with single B-cell antibody discovery: single-cell sorting (microfluidics/FACS) and VH/VL sequencing from single cells.
• Experience with high-throughput antibody discovery platforms (e.g., Hypercell or similar systems) and related workflows.
• Additional strengths: NGS data analysis, antibody engineering (humanization, affinity maturation), and bispecific/multispecific antibodies.

核心能力 | Core Competencies

• 优秀的实验设计与问题解决能力；能够独立推进项目并承担技术owner角色；良好的团队领导与跨团队协作能力；具备英文口头与书面沟通能力。
• Strong experimental design and problem-solving skills; ability to independently lead projects as a technical owner; team leadership and cross-functional collaboration; proficiency in English communication (oral and written).

注：最终岗位将根据候选人的工作年限、技能和经验水平综合确定。Note: the final job title will be commensurate with the candidate’s seniority, skills and level of experience. 

About Angitia

Established in June 2018, Angitia Biopharmaceuticals is a multinational research and development enterprise focusing on discovery and development of new drugs for grievous bone, muscle, and joint diseases. Our mission is to discover, develop and commercialize breakthrough therapeutics that address the key unmet medical needs of serious musculoskeletal diseases. The founder and the core team members of Angitia are seasoned scientific leaders in new drug discovery, development, and management from both overseas and domestic large multinational companies. The company has built an organization distinguished by world-class scientists with talents that are proficient in the pathophysiology of musculoskeletal diseases. We utilize cutting-edge technologies of genetics and molecular biology to uncover new mechanisms, signal transduction pathways and their interactions combined with computer aided drug design to identify new drug targets, and to discover and develop new biological and small molecule medicines. The company is committed to serving patients in need by carrying out innovative science including internal research and external collaborations with academics and global biopharmaceutical companies. We are seeking talent who are innovative, ambitious, and great team players to join our vibrant group.