Senior Scientist II

Revolution Medicines

Revolution Medicines

201-500 employees

Develops targeted therapies for RAS-addicted cancers.


$160,000 - $200,000



San Carlos, CA, USA

Required Skills
Quality Assurance (QA)
  • Ph.D. in pharmaceutical sciences, analytical chemistry, chemical engineering, physical organic chemistry, or related discipline
  • 8+ years of relevant experience in pharmaceutical development
  • Expertise in chemical analysis, material characterization, and solid-state development
  • Experience in small molecule drug preformulation characterization, formulation, and process development of oral and parenteral drug products
  • Hands-on experiences in poorly water drug delivery technologies and enabling formulation development
  • Experience in drug delivery technologies through various dosing routes of administration is a plus
  • Knowledge of basic analytical skills required: HPLC, UV, LC/MS solid-state characterization
  • Knowledge and understanding of current ICH guidelines, GMP guidelines, and related industry practices
  • Working experience and knowledge of regulatory submission (IND, IMPD and / or NDA)
  • Excellent communication (both verbal and technical) and problem-solving skills
  • Ability to multi-task and thrive in a fast-paced innovative environment
  • Lead and/or support activities for pharmaceutical profiling, phase-appropriate formulation development, and drug product manufacturing
  • Responsible for all solid form screening activities related to active pharmaceutical ingredients final form selection, polymorph, cocrystal, and salt screening and crystallization method development for the compounds in development
  • Be involved in crystallization and identifying/selecting CDMOs and oversee the development and manufacturing activities at CDMOs
  • Responsible for conducting solution and solid-state pre-formulation studies for development candidates
  • Collaborate with the Process Chemistry team to identify the final form
  • Oversee the formulation development of compounds for discovery and lead optimization, including intravenous, oral, subcutaneous, and intraperitoneal delivery to support pharmacokinetic, efficacy, and toxicity studies
  • Actively participate in pre-clinical and CMC teams to provide pharmaceutical development/developability input to influence lead identification and optimization
  • Design and execute studies either in-house and/or through CROs/CDMOs to effectively screen candidates and better understand delivery barriers of potential leads pertaining to the intended dosing route, and to enable candidate progression
  • Must have a thorough understanding of drug product manufacturing in a GMP environment, GMP compliance, process implementation, and operation excellence
  • Lead all the preformulation activities to support regulatory submissions
  • Mentor and manage a team of scientists
  • Must think critically and creatively and be able to work independently, determine appropriate resources for resolution of problems, and have strong organizational and planning skills
  • Collaborate with cross-functional teams including but not limited to Medicinal Chemistry, DMPK, Toxicology, QA, Analytical Development, Process R&D, Project Management, and Regulatory to timely achieve project goals

REVOLUTION Medicines stands out in the oncology field for its unique approach to drug discovery, leveraging insights from nature and evolution to develop targeted therapies for RAS-addicted cancers. The company's robust drug discovery and medicinal chemistry capabilities have resulted in a deep pipeline of RAS inhibitors, with their most advanced product, RMC-4630, currently in a multi-cohort Phase 1/2 clinical program. This focus on genetic drivers and adaptive resistance mechanisms in cancer, coupled with their commitment to exploring mechanism-based dosing paradigms and in-pathway combinations, positions REVOLUTION Medicines as a leader in precision oncology.

Company Stage


Total Funding



Redwood City, California



Growth & Insights

6 month growth


1 year growth


2 year growth