FL94 is a NewCo pioneering the discovery of protein editors as a new category of medicines.  To reach this goal we are creating the industry’s first generative covalent chemistry platform foundationed on merging AI with a massively scalable proprietary data generation paradigm that will programmably create actionable covalent small molecules targeted to any protein class.  Both small molecule modulation of canonical function (using mono-valent editors) and novel induced proximity-driven functions (using bi-valent editors) are in scope to treat diseases spread within the full human proteome, not just the currently ligandable.

Position Summary:

FL94 is seeking a motivated Research Associate to join the proteomics team. In this role you will be a critical member of a team responsible for establishing and integrating state of the art chemical proteomics technologies and workflows across all functions within the protein editing platform. Successful candidates will be able to thrive in a lab-based role, as a motivated member of a face-paced team. The individual will have demonstrated evidence of rapidly understanding and achieving expertise in new technologies, while supporting multiple functions. They will be interested in contributing at the bench and be dedicated to scientific development of themselves and their team.

Key Responsibilities:

• Maintain and develop automation capabilities using existing hardware platforms (e.g. Bravo liquid handling) for cell prep and MS analysis
• Ensure rapid and accurate turnaround of data to drive achievement of key project goals
• Work with biology, chemistry and compound management teams to troubleshoot and optimize screening high value targets

The successful candidate will have all the following skills necessary to perform in a fast-paced, purposeful, highly integrated, and pioneering environment

• B.S. or M.S. in analytical chemistry, chemical biology, biochemistry or other related fields with 0-3 years of experience in an industry setting
• Proven hands-on experience in 96-well plate-based cell and biochemical assays
• Experience with mammalian cell culture
• Experience with various affinity-based enrichment assays (e.g. immunoprecipitations) and their subsequent analysis
• Experience operating, optimizing and troubleshooting automated liquid handlers is preferred
• Strong understanding of relevant concepts in cancer biology, protein biochemistry, and a general understanding of chemical reactivity is preferred
• An understanding of LC-MS methods, principles and sample preparation is a plus
• A highly engaged, collaborative and goal/results-orientated style, capable of interfacing and delivering results for multiple functional leads
• Outstanding decision making, organizational and analytical skills

Location: Cambridge, MA