We engineer stem cell transplants that shield healthy cells from targeted therapies
Targeted therapies work by attacking cells that express particular proteins on their surface. Unfortunately, both diseased and healthy cells often express the same proteins, resulting in collateral damage to healthy cells.
At Vor Bio, we engineer hematopoietic stem cells (HSCs) to lack a biologically redundant target protein, then transplant these cells into the patient.
These eHSCs give rise to generations of new healthy blood cells that are effectively shielded from targeted therapies so that only the remaining cancer cells are killed. We are also developing our own CAR-T cell therapy using T cells from the same healthy donor who could potentially provide HSCs for our shielded stem cell transplant and thereby, avoid issues of donor-mismatch. We believe our CAR-T cell therapy may enable more potent and durable responses post-transplant.
Vor Bio is aiming to cure blood cancers through our novel platform combining HSC biology, genome engineering, and targeted therapies to unlock treatment options previously unavailable to patients. Come be a part of a passionate team striving to collaboratively develop a groundbreaking approach to cancer treatment, one of medicine’s greatest challenges.
What we value in our fellow Voracians
Passion: Enthusiastically driving our science toward innovative medicines
Fellowship: Fostering genuine bonds of collaboration and mentorship
Humility: Acting selflessly by putting the collective mission first
Who we are looking for:
Vor Bio is seeking an experienced Quality Control Analyst II/Senior Analytst to be a part of the team responsible for the day-to-day operations assigned to the QC Microbiology group, including sampling of a cGMP manufacturing facility, testing samples in the QC Microbiology laboratory for batch release of advanced therapeutics including cellular and gene therapy products. The role is also responsible for the execution of environmental and utilities monitoring program of multiple cleanroom suites, including collecting and testing samples, and coordinating ID activities with external vendors, and investigating atypical results, and supporting trend analysis. The successful candidate will support and potentially lead continuous improvement initiatives within the group and with cross functional teams. The candidate will work collaboratively with department management to ensure successful execution of the EM program at Vor Bio’s internal manufacturing facility. This individual may be asked to support external provider investigations where required.
Key areas of responsibility:
- Responsible to execute the overall environmental monitoring programs and related microbiology testing to support the internal manufacturing facility
- Responsible to lead the microbiology related testing that occurs with both Vor’s EM program as well as product support (internal and external microbiology and viral related testing)
- Execute day to day EM/Micro operations as assigned to support the manufacturing in the GMP manufacturing facilities
- Ensure adherence to cGMP practices for QC Microbiology laboratory operations and testing
- Support / lead continuous improvement initiatives related to EM topics
- Support the timely generation of the periodic reports for cleanroom environment, utilities, and microbial isolates
- Lead investigations for EM excursions, microbial investigations, and out of specification results and recommend/assist in implementing appropriate corrective actions
- Ensure that training is current for assigned responsibilities
- Work safely within designated spaces, and responding to safety inspections and audits as required / requested
Qualifications:
- BSc, MSc, PhD or equivalent life sciences degree with a minimum of 8 years pharmaceutical industry experience including 2+ years in Quality Control EM/Micro related role(s)
- Experience with cell and gene therapy products preferred
- knowledge of cGMP and ICH requirements for pharmaceutical development and manufacturing, including technical knowledge of standard compendial and microbiological methods
- Experience in regulatory inspections, including dealing with compliance issues identified by regulatory authorities preferred
- Experienced, self-motivated individual who can handle multiple priorities to meet project team goals and timelines
- Excellent written and verbal skills and the ability to communicate clearly, concisely, and effectively
By becoming a team member here at Vor, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you’ll benefit from discretionary time off, parental leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. We are conveniently located in Cambridge with easy access to public transportation and ample parking.
As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation, inclusiveness, and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race, age, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.
Please visit our website at https://www.vorbio.com/ for more information.
