BiomeSense

At-home biosensor with AI microbiome analytics

Head of Engineering

Engineering LeadershipUpdated on Nov 14

Full-timeChicago, IL, USA$150k - $200k /yrIn-person

About the Job

Requirements

At least 8 years of experience in hardware engineering for complex electromechanical systems.
Deep proficiency in computer-aided design (CAD), tolerances, prototyping, and manufacturing.
Experience owning the product lifecycle from concept through transfer and scale-up.
Proven ability to build and manage technical teams.
Systems-level troubleshooting expertise across mechanical, fluidic, and electronic systems.

Responsibilities

Own GutLab hardware architecture, including electromechanical and fluidic systems, and lead design, testing, and refinement through computer-aided design (CAD), prototyping, and manufacturing.
Own validation, stage gates, documentation, and traceability across revisions, firmware, and field performance.
Lead troubleshooting, diagnostics, and closed-loop fixes to eliminate systemic failure modes.
Set and execute standards for all aspects of hardware development, including procurement, transfer, sustaining engineering, and operations.
Drive design for manufacturability (DFM), design freeze, pilot builds, supplier alignment, cost targets, and manufacturing strategy and execution for Gen3.
Mentor and lead a hardware team, aligning resources, timelines, and execution to production milestones.
Address procurement challenges and identify cost-effective solutions.
Partner with other leaders to align hardware development with broader company strategy and goals.

Head of Engineering
Compensation: $125K– $200K (salary + bonus), up to 1.0% equity stock options
Full benefits, including health coverage, PTO & parental leave

About BiomeSense
BiomeSense is a life sciences startup applying gut microbiome technologies (GutLab, MetaBiome) to advance personalized medicine. We partner with UCSF, UCSD, NIH & the University of Chicago & are backed by LabCorp Ventures, Bluestein Ventures, Seerave Foundation & Emil Capital Partners.

Role Summary
Own the full hardware (HW) lifecycle for GutLab, from architecture & subsystem integration through manufacturing, validation & deployment for a complex electromechanical device & BOM. Act as final technical authority for GutLab system performance, fleet stability & next generation GutLabs (Gen3) production, combining hands-on engineering depth with strategic judgment to ensure current systems perform reliably in the field & Gen3 scales into manufacturing.

Key Responsibilities:

System Ownership & Development: Own GutLab architecture (electromechanical & fluidic); lead design, testing & refinement via CAD, prototyping & manufacturing
Validation & Deployment Readiness: Own validation, stage gates, documentation & traceability across revisions, firmware & field performance. Lead troubleshooting, diagnostics & closed-loop fixes to eliminate systemic failure modes
End-to-End Execution: Set & execute high standards for all aspects of HW development: procurement, transfer, sustaining engineering & operations
Manufacturing Scale-Up: Drive DFM, design freeze, pilot builds, supplier alignment, cost targets & manufacturing strategy + execution for Gen3
Team Leadership: Mentor & lead a HW team; align resources, timelines & execution to production milestones
Strategic Problem Solving: Address any and all procurement challenges while identifying cost-effective solutions
Cross-Functional Collaboration: Partner with other leaders to align hardware development with broader company strategy & goals

Qualifications

8+ years’ experience in hardware engineering for complex electromechanical systems
Deep proficiency in CAD, tolerances, prototyping & manufacturing

Product lifecycle ownership (concept through transfer & scale-up)
Proven ability to build & manage technical teams
Systems-level troubleshooting expertise across mechanical, fluidic & electronic
Structured, decisive & execution-oriented with high accountability
A strategic thinker who thrives under pressure in fast-paced environments

Hiring Process Note: We are a small team and we review all resumes, screening questions and assessment scores manually. However this focus on manual review limits our ability to respond to direct messages through LinkedIn and other channels. We appreciate your effort in applying and we thank you for your understanding.

About the Company

BiomeSense

At-home biosensor with AI microbiome analytics

BiomeSense offers a platform for gut microbiome analysis that combines an at-home biosensor for continuous monitoring with a cloud-based AI-powered analytics system. It enables longitudinal, low-cost data collection for clinical trials and consumer health, moving beyond single-time-point samples. The biosensor gathers microbiome-related data at home and transmits it to the cloud, where AI analyzes trends to generate insights. It differentiates itself by providing an integrated hardware-software solution for large-scale data collection, helping researchers and product developers accelerate precision medicine.

Company size: 11-50
Company stage: Seed
Total funding: $5.4M
Headquarters: Chicago, IL
Founded: 2018

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