Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

Revolution Medicines’ Cancer Biology group is looking for a talented senior research associate with a strong background in biochemistry, molecular and cell biology to support early target discovery, screening, and validation efforts for novel oncology programs. The successful applicant will join the Chemical Biology and Proteomics team within Discovery Biology. They will work closely with scientists and utilize a wide array of cellular, molecular biology, and biochemical assays to support validation of novel targets for RevMed’s unique molecular glue platform. The ideal candidate will have hands-on experience with mammalian cell culture and manipulation and standard molecular biology and biochemistry techniques, including troubleshooting and assay development. Above all, we are looking for a highly motivated and driven team player to join our diverse and talented team of scientists at RevMed.

Responsibilities:

• Work with scientists in the Chemical Biology and Proteomics team to follow up on biochemical and cellular high-throughput screening hits and perform mechanistic experiments as part of hit validation efforts

• Perform bioassays to interrogate effects of novel compounds on cellular pathways, including plate-based cellular assays using reagent kits and automated liquid handlers

• Engineer cell lines and establish cellular assay systems

• Maintain cultures of multiple cancer cell lines to support experimental efforts

• Generate high quality data in a timely manner and maintain detailed experimental records

• Work with project scientists to process and analyze data and design new experiments

• Regularly and effectively communicate findings at group meetings

Required Skills, Experience and Education:

• Bachelor’s degree or Master’s degree in molecular biology, biochemistry, biotechnology, or related field

• 5+ years of experience in a cell biology/molecular biology role

• Hands-on experience culturing, manipulating and characterizing mammalian cells: cell culture, viability and other bioassays (e.g. western blot, qPCR, CTG)

• Experience with biochemical and recombinant protein assays and protein analysis by LC-MS

• Excellent written and verbal communication, attention to detail, and record keeping

• An energetic and proactive team player with the ability to work efficiently in a dynamic company environment

Preferred Skills, Experience and Education:

• Viral transduction and CRISPR/Cas9 gene editing experience

• Experience with automated liquid handling systems

• Analysis of concentration-response curves and scientific data analysis software

The base salary range for this full-time position is $95,000 to $120,000 for candidates based at our headquarters in Redwood City, CA. The range displayed on each job posting is intended to be the minimum and maximum salary for the position in Redwood City and will be adjusted for the local market a candidate is based. Our salary ranges are determined by role, level, and location. Individual pay is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact [email protected].

#LI-Hybrid   #LI-LN1