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Praxis Precision Medicines

Clinical-stage biopharma developing CNS therapies

Senior Software Engineer - AWS Cloud Infrastructure

Cloud EngineeringConfirmed live in the last 24 hours
Full-timeRemote in USA$125k - $150k /yr

About the Job

Requirements

  • Senior-level software engineering experience, with substantial hands-on experience building and operating production systems on AWS.
  • Strong full-stack engineering capability in TypeScript and Python, including APIs, services, tooling, and cloud automation.
  • Deep experience with core AWS services used in enterprise environments, including IAM, Organizations, VPC, EC2, ECS/EKS or Lambda, S3, RDS/DynamoDB, CloudWatch, KMS, Config, and GuardDuty.
  • Proven ability to design and operate AWS governance at scale, including multi-account strategy, policy guardrails, access control, security standards, and operational controls.
  • Strong AWS networking fundamentals, including VPNs, peering, Transit Gateway, routing, DNS, and hybrid connectivity.
  • Experience with enterprise SSO; Microsoft Entra ID (Azure AD) federation into AWS, including SAML/OIDC, IAM Identity Center, application and role mapping, and access lifecycle practices.
  • Experience working in regulated or audit-ready environments, with strong habits around change control, evidence and traceability, least privilege, and durable controls.
  • Demonstrated operational ownership: able to establish meaningful alerts and monitors, reduce noise, improve reliability, respond to incidents, and turn operational learnings into engineering improvements.
  • Strong Infrastructure as Code experience.
  • Experience with Bitbucket Pipelines and/or GitHub Actions.
  • Proficiency with modern AI coding and productivity tools, with the judgment to validate outputs, test changes, manage risk, and maintain production quality.
  • The role requires regular use of a computer, devices or other office equipment, clear communication, occasional movement, comfort with screen work, basic hand coordination, and focus; reasonable accommodations may be made.

Responsibilities

  • Own and evolve AWS architecture for enterprise workloads, including multi-account foundations, landing zone and Control Tower patterns, networking, security baselines, and shared platforms.
  • Establish and continuously improve AWS governance, including organizational structure, SCPs, tagging, cost controls, compliance, audit readiness, and durable operational standards.
  • Design and operate identity and access across AWS, including IAM, IAM Identity Center, and Microsoft Entra ID integrations for SSO, federation, role mapping, access reviews, and least-privilege access.
  • Build, harden, and operate AWS platforms and full-stack services using TypeScript and Python, including compute, containers, serverless, data stores, messaging, and cloud automation as needed.
  • Drive operational excellence across AWS platforms and workloads by building monitoring, alerting, dashboards, SLOs/SLIs, runbooks, incident response practices, and durable fixes to recurring problems; participate in the on-call rotation and own incidents through resolution and learning.
  • Automate infrastructure and delivery through Infrastructure as Code and CI/CD, emphasizing safe, incremental delivery and low blast radius.
  • Partner across engineering and IT to translate needs into secure, maintainable solutions, improve production readiness and operational practices, mentor other engineers, and use sound judgment to move quickly without breaking things.

Desired Qualifications

  • Experience with enterprise SSO; Microsoft Entra ID (Azure AD) federation into AWS is strongly preferred, including SAML/OIDC, IAM Identity Center, application and role mapping, and access lifecycle practices.
  • Pulumi and/or SST are strongly preferred; Terraform or AWS CDK experience is transferable and welcome.

About the Company

Praxis Precision Medicines

Clinical-stage biopharma developing CNS therapies

Praxis Precision Medicines develops therapies for central nervous system disorders driven by neuronal imbalance, with a focus on genetic epilepsies. Its treatments target restoring balance in CNS networks and are advanced in clinical development to address unmet medical needs. The company differentiates itself by using patient-guided development and forming partnerships to align with real patient needs. Its goal is to bring effective CNS therapies to patients and caregivers by advancing through clinical development toward potential commercialization and collaborations.

Company size
201-500
Company stage
IPO
Headquarters
Cambridge, MA
Founded
2015

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