LNP Discovery Co-op

Company Overview:

Strand Therapeutics is a clinical-stage biotechnology company pioneering programmable mRNA therapeutics to unlock the full potential of genetic medicines. Strand is applying its proprietary Signal Stack platform, which integrates EverScript circular RNA, AmpliScript self-replicating RNA, SignalPath targeted delivery, and logic-driven SignalLock genetic circuits to enable precise control of therapeutic activity across tissues and cell types and overcome foundational limitations in targeting, durability, and safety.

Strand is advancing a pipeline with an initial focus on oncology and autoimmune disease. Its initial program, STX-001, an intratumorally delivered LNP-encapsulated self-replicating RNA expressing IL-12, has demonstrated preliminary evidence of systemic immune activation and anti-tumor activity in patients with advanced solid tumors who have progressed on prior therapies. Building on this early clinical validation, intravenously delivered STX-003 is designed for tumor-targeted expression and avoidance of off-target expression. STX-003, which is expected to enter the clinic in mid-2026, has the potential to be a major step forward for the fields of genetic medicine and oncology. Strand is also advancing STX-005, an in vivo CAR-T program designed to enable controlled, durable expression and repeat dosing. Founded by MIT synthetic biology pioneers, Strand has raised over $250 million and is headquartered in Boston, MA. 

Become the next standout single strand!

Job Summary:

Strand is looking for people who have the enthusiasm and motivation to be a highly contributing member of a small but extremely productive team. This opportunity will offer the employee the ability to work in a matrix-based environment and be a part of the future strategy of the company.

We are looking for a highly motivated and innovative candidate for the role of Co-op, LNP Discovery. This is a fantastic opportunity to make a significant impact as a scientifically motivated self-starter capable of independently conceiving, conducting, and critically analyzing his/her own work with minimal supervision.

Primary Responsibilities:

• Executing formulation related experiments including preparing, optimizing, and characterizing the LNP formulations.
• Carrying out some bioassays for evaluating the LNP formulations.
• Facilitating general lab techniques such as sample preparation, cell culture, and nucleic acid work.
• Working across diverse areas to support the group's research activities in a fast-paced and collaborative environment.

Qualifications:

• On track to graduate with a B.S. or M.S. in Biology, Biochemistry, Bioengineering, or a related discipline.
• Coursework related to dosage forms, drug/gene delivery system, and nanotechnology are desirable.
• Experience with production and analytical characterization of LNP formulation is a big plus.
• Ability to write, edit, and follow standard operating procedures, make careful observations, maintain clear and complete records of lab work.‪

Strand Therapeutics is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law. Strand does not accept unsolicited resumes from any source other than directly from candidates. 

Job Type: Co-op

Hourly Rate: $25 - $28 / hour