We engineer stem cell transplants that shield healthy cells from targeted therapies

Targeted therapies work by attacking cells that express particular proteins on their surface. Unfortunately, both diseased and healthy cells often express the same proteins, resulting in collateral damage to healthy cells.

At Vor Bio, we engineer hematopoietic stem cells (HSCs) to lack a biologically redundant target protein, then transplant these cells into the patient.

These eHSCs give rise to generations of new healthy blood cells that are effectively shielded from targeted therapies so that only the remaining cancer cells are killed. We are also developing our own CAR-T cell therapy using T cells from the same healthy donor who could potentially provide HSCs for our shielded stem cell transplant and thereby, avoid issues of donor-mismatch. We believe our CAR-T cell therapy may enable more potent and durable responses post-transplant.

Vor Bio is aiming to cure blood cancers through our novel platform combining HSC biology, genome engineering, and targeted therapies to unlock treatment options previously unavailable to patients. Come be a part of a passionate team striving to collaboratively develop a groundbreaking approach to cancer treatment, one of medicine’s greatest challenges.

What we value in our fellow Voracians

Passion: Enthusiastically driving our science toward innovative medicines

Fellowship: Fostering genuine bonds of collaboration and mentorship

Humility: Acting selflessly by putting the collective mission first

Who we are looking for

Vor Bio is seeking an Associate Scientist II, to join our Bioanalytical Chemistry team. The successful candidate will be integral in developing and executing robust analytical assays for critical starting materials used in our novel therapies. The position requires enthusiasm, passion, attention to detail and a desire to create new medicines for patients. This position will be reporting to the Bioanalytical Chemistry Group in the Process and Analytical Development team at Vor Bio. This group is responsible for developing, optimizing, executing, evaluating, validating, transferring bioanalytical assays primarily HPLC/UPLC/LCMS-based analytical methods and using these methods to characterize the critical starting materials used in developing our therapies.

Key areas of responsibility

Execute HPLC-based or other bioanalytical assays independently following established protocols - involving data acquisition, mobile phase/buffer preparation, instrument maintenance, troubleshooting, data analysis and report generation
Methodically test various conditions for new assay development and optimization
Maintain a detailed and updated ELN record of experiments conducted
Analyze and visualize experiment data
Collaborate with other groups/teams to perform in-process testing of materials and complete reporting workflows for those data in a timely manner
Write SOPs and update SOPs of existing assays in established non-GXP or GXP workflows as needed
Work cross-functionally to learn new platforms/assays that can be used to characterize raw materials
Perform literature searches to inform experiment design
Present study designs and results to internal and external stakeholders communicating in an effective manner to drive decision-making among stakeholders
Support and maintain critical starting material inventory, distributing critical starting materials as needed for studies and maintaining updated records of material distribution

Qualifications

BS Coursework in Biochemistry or Biotechnology
2+ years of analytical chemistry/biochemistry lab-based experience
Ability to work collaboratively in a team environment
Ability to consistently deliver exceptional results with impeccable attention to detail
Self-driven and motivated to excel
Ability to pivot in a fast-paced industry
Excellent problem-solving and communication skills
Creative, analytical and action-oriented mindset
Training in basic lab safety/chemical safety and various sample prep techniques
Track record of intellectually challenging oneself to enhance scientific capabilities

Preferred Qualifications

MS Coursework and/or co-op/internship experience in Analytical Biochemistry is preferred
1+ years of experience with HPLC/ Chromatography methods development/optimization is preferred
1+ years of experience designing and set-up of complex study designs; eg. Stability study

By becoming a team member here at Vor, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you’ll benefit from discretionary time off, parental leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. We are conveniently located in Cambridge with easy access to public transportation and ample parking.

As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation, inclusiveness, and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race, age, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

Please visit our website at https://www.vorbio.com/ for more information.

Associate Scientist II

Bioanalytical Chemistry

Vor Bio

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