Senior Scientist

Company Overview: Abiologics, Inc. is a privately held, early-stage biotechnology company on a mission to make biology better through an innovative therapeutic modality. We are pioneering the development of Synteins^TM, a transformational class of macromolecular medicines unlocked by novel synthetic and computational technologies. Abiologics is actively seeking exceptional molecular scientists who are passionate about driving therapeutic modality innovation in biotechnology.

Abiologics was founded in Flagship Pioneering’s venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA) and Generate Biomedicines were conceived and created. Since Flagship’s founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures resulting in more than 500 issued patents and more than 50 clinical trials for novel therapeutic agents.

Position Summary: We are looking for a highly motivated, experienced cell biologist and assay development/screening scientist to join our growing team. In this role, the successful candidate will be responsible for developing and executing novel cell-based screening assays to drive the Abiologics Syntein^TM discovery platform. This is a hands-on, lab-based role and will collaborate cross-functionally with a diverse design-make-test team across Abiologics and have the opportunity to impact platform and company build-out. Occasionally, the incumbent may contribute to in vivo and ex-vivo pharmacology activities to progress the projects and the platform.

Key Responsibilities:

• Design, develop and execute cell-based screening assays to assess Syntein^TM activity, target engagement and mechanism of action to drive discovery programs
• Lead cell biology efforts within the Discovery team to identify and implement relevant cell-based assays for diverse target classes and disease areas
• Collaborate within the Discovery and Biology teams on biochemistry and biophysics projects and provide cell biology expertise and guidance to junior team members
• Collaborate cross-functionally to enable novel methods, assays and screening workflows
• Ensure rapid generation and accurate reporting of high-quality data and collaborate with Computational Design and Chemistry teams to drive design-make-test cycles
• Effectively communicate scientific findings and ideas to a diverse team both informally and at project team meetings

Qualifications:

• PhD in molecular or cell biology or related discipline with minimum 3 years relevant experience in industry required
• Technical expertise with mammalian cell culture including establishing and maintaining cell lines, transient and stable transfection, and reporter cell lines
• Proficient in industry-standard cell-based assay and bioanalytical techniques including TR-FRET, ELISA, flow cytometry, and reporter gene; experience with cellular/high content imaging and image analysis a plus
• Experienced with primary cell culture and characterization, including tissue dissociation and cell isolation of various immune cell types
• Demonstrated ability to independently design, develop and optimize diverse cell-based assays and interpret complex results
• In vivo pharmacology expertise highly desired
• Disease biology expertise in at least 2 of the following: immunology, or oncology, metabolism and neuroscience Proficiency in laboratory automation and semi-automated screening workflows a plus
• Industry level experience with best practices related to data records creation and maintenance and workflows integrity
• Demonstrated ability to work in a fast-paced environment; self-driven, creative, with a strong team-oriented mentality