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Fujifilm demonstrates the utility of AI-AAM(R), the core technology behind its AI-powered drug design service "drug2drugs(R)" Joint Research Findings with The Institute of Science and Industrial Research, Osaka University and Other Institutions in Academic Journal Discovery of Novel, Highly Potent Inhibitors Starting from Known Active Compounds TOKYO, September 30, 2026 FUJIFILM Corporation has demonstrated, through a collaborative research project with research groups from Osaka University, Okayama University, Kindai University, the Institute of Microbial Chemistry, and Kyushu University, that AI-AAM(R), the core technology behind its proprietary AI drug design service drug2drugs(R), is useful for designing novel bioactive compounds starting from known active compounds[*1]. In this study, AI-AAM(R) enabled the discovery of novel inhibitors targeting proteins involved in the virulence and antimicrobial resistance of pathogenic bacteria. The research results were published in The Journal of Antibiotics, an international academic journal in the field of antibiotic research, on September 30, 2026 (Japan time). AI-AAM(R) is Fujifilm's proprietary computational science technology that combines its unique Amino Acid Mapping (AAM) descriptor, which quantifies the binding affinity between the amino acids that constitute a target protein and a compound to predict the binding affinity between the protein and the compound, with Fujifilm's proprietary AI technology[*2] for designing novel compounds with stable chemical structures. AI-AAM(R) can identify and design new compounds based solely on the chemical structure of a known active compound, without the detailed structural analysis of the target protein that has conventionally been required. As the global spread of antimicrobial-resistant bacteria continues to pose a major challenge, there is growing interest in developing infectious disease therapeutics with novel mechanisms of action that target pathways involved in bacterial virulence and antimicrobial resistance. In this collaborative research, AI-AAM(R) was used to search a virtual library of approximately 12 million compounds, starting from a natural organic compound known to inhibit histidine kinase, which plays a central role in signal transduction involved in bacterial virulence and antimicrobial resistance. As a result, the researchers identified 714 inhibitor candidates with chemical scaffolds[*3] distinct from that of the natural organic compound, which has a complex scaffold and exhibits cytotoxicity. The candidate compounds have chemical scaffolds that are easier to synthesize. Among these candidates, compounds with highly novel scaffolds were selected. By designing and synthesizing derivatives[*4] based on the selected scaffolds, highly active histidine kinase inhibitors were successfully obtained from only a dozen or so derivatives[*5] (Figure 1). These results demonstrate that AI-AAM(R) can efficiently narrow down candidates for further derivative design and synthesis from a large compound library, significantly reducing the number of derivatives that need to be synthesized while still enabling the discovery of highly active compounds. This study demonstrates that AI-AAM(R) can be used to identify and design novel candidate compounds based on known active compounds even when detailed three-dimensional structural information on the target protein is unavailable, highlighting the value of AI-AAM(R) in drug discovery research. * Figure 1. Chemical structures of the natural active compound (left) and the novel inhibitor candidates discovered using AI-AAM(R)(right), together with their experimentally determined inhibitory activity values (IC[50], μM). While the natural active compound has a complex chemical scaffold, the novel inhibitor candidate possesses a scaffold that is easier to synthesize chemically. Fujifilm provides drug2drugs(R), an AI-powered drug design service that leverages AI-AAM(R) as its core technology to support the identification and design of compounds with novel scaffolds starting from known active compounds. Going forward, Fujifilm will continue to utilize AI-AAM(R) and other proprietary technologies to improve the efficiency of drug discovery research and contribute to the creation of innovative new medicines. * *1 A compound that binds to and acts on a disease-related protein (target protein). * *2 Fujifilm's proprietary AI technology that extracts structural requirements for chemical stability from vast numbers of compounds registered in chemical databases and designs entirely new compounds based on those requirements. * *3 The fundamental framework formed by the connectivity of atoms within a molecule. * *4 The process of designing and chemically synthesizing a variety of derivatives based on a given compound. * *5 A compound obtained by chemically modifying part of the structure of a specific compound. Publication information. * Journal - The Journal of Antibiotics (Springer Nature) * Article Title - Amino acid mapping-guided scaffold selection and hit identification of histidine kinase inhibitors from a virtual library of over 12 million compounds * Publication Date - 9:00 AM September 30, 2026 (Japan Time) Contact. FUJIFILM Corporation CRO Business Development Office * * Please note that the contents including the product availability, specification, prices and contacts in this website are current as of the date of the press announcement and may be subject to change without prior notice.

Cricut StickerPix Print + Cut and StickerPix Print price, specifications and availability announced. Ali Jennings Camera Jabber Author Published: 27th September 2026 Cricut, best known for its crafting cutters, has launched two new machines that bring it into the world of home photo printing. The Cricut StickerPix Print + Cut and Cricut StickerPix Print are designed to turn the photos on your phone into stickers, labels, photo prints and cards. It's a new category for the brand, and it puts Cricut up against the compact photo printers from the likes of Canon, Kodak and Fujifilm that have become popular for printing straight from a phone. Two machines, one process. Both printers use thermal dye-sublimation, which Cricut says produces high-resolution 300dpi prints that are water, scratch and fade resistant thanks to a laminate layer applied during printing. The StickerPix Print + Cut is the more capable of the pair. It prints, laminates and then cuts custom shapes using a built-in fine-point blade, so you can go from a photo to a finished die-cut sticker in a single pass. It can also produce photo prints, photo cards and custom-cut labels. The StickerPix Print uses the same printing technology but skips the cutter, working instead with pre-cut Cricut Sticker Sheets in a range of shapes and sizes. It also handles photo prints and cards. Design Space and AI tools. Both machines connect via Bluetooth to Cricut's Design Space software on mobile and desktop. Users can start with their own photos, edit templates, use AI-powered features or choose from a library of more than 1.8 million sticker images. Cricut notes that the full content library and some software features, including Cricut AI, require a paid Cricut Access subscription. "Cricut StickerPix brings these trends together and makes it incredibly easy to turn what's on your screen into something you can hold, share, and make your own," said Ashish Arora, CEO at Cricut. Its take. For photographers, dye-sub printing is a proven route to durable, continuous-tone small prints, and the ability to cut around a subject is something traditional mini photo printers can't do. The subscription requirement for some features and the reliance on Cricut's own sticker sheets are worth bearing in mind when weighing up running costs. Cricut StickerPix key features. Thermal dye-sublimation printing: at 300dpi Laminated prints: water, scratch and fade resistant StickerPix Print + Cut: print, laminate and precision cut in one machine StickerPix Print: prints and laminates onto pre-cut Cricut Sticker Sheets Bluetooth connection to Design Space: on mobile and desktop Outputs: stickers, labels, photo prints, photo cards Cricut StickerPix price and availability. The Cricut StickerPix Print + Cut Essential Bundle costs £249.99 and the Cricut StickerPix Print Essential Bundle costs £159.99. Both are available from 25 September 2026 through Cricut.com and retailers including Hobbycraft, Currys, Very, Amazon, John Lewis and Argos.

FUJIFILM Dimatix Introduces the STARFIRE PhaseMaster Printhead. FUJIFILM Dimatix, Inc. has announced the latest addition to its STARFIRE(R) printhead family: the STARFIRE(R) PhaseMaster hot-melt inkjet printhead (hereafter "PhaseMaster"). Engineered for demanding high-speed scanning and single-pass industrial systems, the PhaseMaster can operate with or without ink recirculation and can be integrated into high-performance printing platforms. Its combination of jetting performance, productivity, and durability makes it well suited for complex industrial and graphic arts applications. This printhead is targeted at established industry segments, including marking and coding, packaging, and screen printing, as well as growing industrial segments, including additive manufacturing and printed electronics for etch-masking applications such as photovoltaic cells. "We are excited to bring the PhaseMaster product to market at this important time," said Shane O'Neill, director of business development at FUJIFILM Dimatix, Inc. "PhaseMaster reflects our commitment to delivering robust, cost-effective solutions that provide reliable performance in demanding industrial print environments. Building on more than 20 years of proven success with the Galaxy HotMelt printhead and leveraging the well-established reputation of the STARFIRE(R) platform for durability and serviceability, we have combined the strengths of both technologies to create a unique solution for jetting phase-change solid inks at high resolution with outstanding reliability and consistency. As the newest addition to the STARFIRE(R) product family, PhaseMaster is engineered to deliver high performance, productivity, and long-term value across a wide range of current and emerging applications." Main PhaseMaster features: Performance * 400 dpi resolution with drop sizes of 30-200 pL, depending on configuration * Integrated heater and temperature sensor ensure optimal jetting conditions * Wide viscosity range of 8-20 cP (10-14 cP for maximum productivity) * Designed for continuous operation at temperatures up to 257°F (125°C) * VersaDrop(R) binary and grayscale jetting with an open, editable waveform utility * Compatibility with full-color, monochrome, computer-to-screen, wax-based, and hot-melt ink applications, including single-pass coding and marking Productivity * Jet design featuring REDIJET(R) Energy Dissipation technology for sustained, high-quality output, with durability supported by FUJIFILM Dimatix bulk PZT actuators insulated from direct contact with fluids * REDIJET(R) Dual Recirculation for reliable jetting[[1]] * Multi-pulse jetting at up to 30 kHz, delivering speeds exceeding 60 meters per minute * High ink-laydown capability of nearly 57 grams per square meter Durability * FUJIFILM Dimatix Bulk PZT actuators that are insulated from direct contact with fluids * Industrial design to meet customer demands in challenging environments * Robust (repairable) printhead enabling cost-effective maintenance and support As with all FUJIFILM Dimatix products, the company's worldwide field-support network is readily available and offers a variety of training and educational opportunities to help customers maximize the capabilities of their printheads, including a specialized program for developing waveforms that optimize performance. FUJIFILM Dimatix is currently working with select strategic partners to bring STARFIRE(R) PhaseMaster-based products to market. The printhead will be available worldwide in early 2027. For more information about printhead solutions available from FUJIFILM Dimatix, Inc., please visit https://www.dimatix.com. [1] The printhead can be configured without recirculation About fujifilm. FUJIFILM Dimatix, Inc., a leading global supplier of drop-on-demand inkjet printheads for commercial and industrial applications, is driving a revolution in inkjet technology to support a new generation of products for printing, industrial product decoration, and materials deposition. The company's innovative inkjet technology and world-class fabrication techniques enable OEMs, system integrators, and manufacturers to build cutting-edge systems and manufacturing processes for high-performance, precision printing of traditional inks and deposition of functional fluids on all types of surfaces, including flexible substrates. FUJIFILM Dimatix, Inc. is headquartered in Santa Clara, California, and maintains U.S. product-development and manufacturing operations in California and New Hampshire. The company sells and supports its products worldwide through offices in the United States, Europe, Japan, and China. FUJIFILM Holdings Corporation, headquartered in Tokyo, leverages its depth of knowledge and proprietary core technologies to deliver innovative products and services across the globe through the four key business segments of healthcare, electronics, business innovation, and imaging with over 70,000 employees. Guided and united by its Group Purpose of "giving our world more smiles," The Cannata Report address social challenges and create a positive impact on society through its products, services, and business operations. Under its medium-term management plan, VISION2030, which ends in FY2030, The Cannata Report aspire to continue its evolution into a company that creates value and smiles for various stakeholders as a collection of global leading businesses and achieve a global revenue of 4 trillion yen. For more information, please visit: https://holdings.fujifilm.com/en. FUJIFILM, DIMATIX, and STARFIRE are trademarks of FUJIFILM Corporation and its affiliates.