What if... We could harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner?
Flagship Pioneering is a biotechnology company that invents and builds platform companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps. Those big leaps in human health and sustainability exponentially accelerate scientific progress in areas ranging from cancer detection and treatment to nature-positive agriculture.
What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our scientific founders, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and transform for the benefit of people and planet.
Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies.
Pioneering Medicines, an initiative of Flagship Pioneering, is building a world-class biopharmaceutical R&D capability focused on conceiving and developing life-changing treatments for patients by harnessing the power of Flagship’s scientific platforms and applying those innovative approaches to serious diseases with unmet medical need. Unique to Pioneering Medicines’ approach is the opportunity to combine platforms to create truly novel and potentially transformative treatments.
Position Summary:
We are seeking a skilled and motivated individual to drive strategy and provide technical expertise in toxicology from discovery to development across our diverse drug discovery portfolio. In this role you will provide project teams with toxicology strategy that is stage-appropriate. We are seeking individuals who are analytical, goal-oriented and committed to maintaining the highest scientific and ethical standards.
Key Duties and Responsibilities include, not limited to, the following:
- Serve as the project toxicologist for projects at various stages of discovery and development
- Conduct safety assessments (on- and off-target)
- Contribute to study design, planning, execution, and monitoring of external non-GLP and GLP toxicology studies (in vitro and in vivo) studies
- Contribute to the development an in silico and in vitro screening strategy to understand potential toxicological liabilities for new modalities
- Manage contracts and coordinate activities with CROs for non-GLP and GLP toxicology studies
- Support the preparation of study reports with external labs
- Lead the preparation of regulatory documents, including INDs, investigator’s brochures, and NDAs/BLAs
- Work closely with other functional areas such as biology, in vitro and in vivo pharmacology, DMPK, modeling and simulations, CMC and Clinical as well as internal and external collaborators
Qualifications and Skills
- BS, MS or PhD in toxicology, pharmacology, physiology, biology, immunology or related sciences
- Experience in preclinical/nonclinical safety, pharmacology, and/or biology experience in the pharmaceutical/biotechnology industry
- 10+ years required for Bachelors degree
- 8+ years required for Masters degree
- 5+ years required with PhD
- Study design, planning, execution, and monitoring experience for external non-GLP and GLP toxicology studies (in vitro and in vivo) studies
- Safety assessment experience (on- and off-target)
About Flagship
Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.
At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
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