Vice President - Enterprise Technology

Position Summary:

Avalo is a publicly traded, clinical-stage biotechnology company advancing abdakibart into Phase 3. As the company moves toward late-stage development and potential commercialization, its technology foundation must scale to be secure, validated, inspection-ready, and built to support a growing, distributed workforce.

The Vice President, Enterprise Technology will build and lead the technology platform that carries the company from Phase 2 into Phase 3 and beyond. This leader owns core infrastructure, enterprise business systems, including clinical and quality platforms, cloud operations, cybersecurity, enterprise architecture, and the technology and governance foundation that enables the company's data, analytics, AI, and automation capabilities. This is a builder role requiring strategic vision, hands-on execution, and the rigor required of a public company in a regulated industry, including GxP, SOX, and SEC cybersecurity expectations.

Essential Duties and Responsibilities:

• Build and execute a multi-year enterprise technology roadmap aligned with Phase 3 execution, pipeline expansion, and commercial readiness.
• Design a scalable, integrated architecture that connects corporate, clinical, quality, and finance systems.
• Partner with the SLT to translate business priorities into technology investments with clear KPIs.
• Own enterprise applications, including Controlled Content and Quality Management systems based on Veeva platform, ERP, HR, FP&A/accounting software, procurement, and collaboration tools.
• Partner with Clinical Operations, Quality, and Regulatory on platforms such as CTMS, eTMF, EDC integrations, QMS, and RIM.
• Partner with QA in leading computer system validation to ensure compliance with GxP and 21 CFR Part 11.
• Maintain SOX IT general controls in partnership with Finance and external auditors.
• Lead the enterprise cybersecurity program, including identity and access, endpoint, zero trust, incident response, and third-party risk.
• Provide cybersecurity reporting to senior management and Audit Committee and support SEC cybersecurity disclosure requirements.
• Protect sensitive data, including clinical trial data, intellectual property, and personal data under PIP, GDPR, and state privacy laws.
• Ensure high availability and reliability across cloud, network, and endpoint environments for a distributed workforce.
• Oversee secure data exchange with CROs, CDMOs, and other external partners.
• Establish and maintain the enterprise data architecture, platforms, integration standards, and technology controls required to support effective data governance, analytics, and AI capabilities across the company.
• Establish and oversee the enterprise technology, security, and governance framework supporting responsible adoption of AI, automation, and advanced analytics, ensuring solutions are scalable, secure, compliant, and integrated with Avalo's enterprise technology environment.
• Partner with the Senior Director, AI & Data Transformation to govern AI initiatives through a shared approval model, ensuring business value and adoption are paired with sound technology architecture, security, privacy, integration, validation, and deployment readiness.
• Own the technology budget, including capex/opex planning, forecasting, licensing, vendor selection, and managed service provider performance.
• Hire, develop, and scale a high-performing team across IT operations, business systems, and security.
• Promote a service-oriented culture focused on employee experience, enablement, and continuous improvement.

Required Education and Experience:

• Bachelor's degree in computer science, Information Technology, Engineering, or a related field, or equivalent experience. Advanced degree a plus.
• 15+ years in IT, enterprise technology, or software engineering, including 7+ years in senior leadership at the Director level or above.
• Experience in biotech, pharma, life sciences, or other highly regulated industries such as fintech or financial services.
• Track record of leading enterprise transformation in a scaling organization, including ERP, cloud, and systems integration.
• Hands-on leadership of a cybersecurity program using recognized frameworks such as NIST CSF, ISO 27001, or SOC 2.
• Working knowledge of GxP, 21 CFR Part 11, computer system validation, and SOX IT general controls.
• Experience enabling enterprise AI, automation, advanced analytics, or modern data capabilities within a secure and governed technology environment.
• Deep familiarity with cloud architecture, API-first integration, and modern data platforms.
• Preferred experience includes public company reporting, senior management & board-level engagement, Phase 2 to Phase 3 transition, NDA/BLA submission or commercial launch readiness, function-building in a high-growth company, certifications such as CISSP, CISM, or relevant cloud certifications, and a professional network in the Greater Philadelphia life sciences community.

Additional Skills, Knowledge, and/or Abilities:

• Comfortable creating structure and scaling it with discipline.
• Translates technology into business outcomes and speaks credibly with executives and the board.
• Establishes practical guardrails that allow AI, automation, and analytics to scale while protecting data, compliance, and inspection readiness.
• Attracts strong people, develops them, and builds a team culture of ownership.
• Strong written and verbal communication skills, including the ability to communicate complex technology and risk topics to non-technical audiences.
• Demonstrated vendor governance, budget ownership, procurement discipline, and contract negotiation skills.
• Ability to lead through influence across distributed teams, external partners, and executive stakeholders.

Other Requirements:

• Onsite a minimum of 3 days per week.
• Availability to respond to urgent business or system issues outside standard business hours on an as-needed basis.
• Travel may be required to meet with external partners, vendors, auditors, and/or to attend industry events.