Full-Time

Principal Design System Designer

Twin Health

Twin Health

501-1,000 employees

Delivers digital twin for metabolic health.

Compensation Overview

$220k - $230k/yr

+ Equity participation

No H1B Sponsorship

Remote in USA

Remote

Applicants must be authorized to work in the U.S.; visa sponsorship not provided.

Category
UI/UX & Design (1)
Required Skills
Figma
iOS/Swift
Android Development
Requirements
  • 8-10 years of experience as a system designer.
  • A proven track record as a Principal Designer who has successfully built a 0–1 design system or led a massive overhaul of an existing one at scale within a top-tier, fast-paced tech environment.
  • Visual & Systems Excellence: An outstanding portfolio that demonstrates exceptional execution and visual craft, inextricably linked with deep, scalable, and systematic thinking.
  • Multi-Platform Architecture: Experience designing scalable systems that translate seamlessly across Web desktop, native iOS and Android, understanding the unique technical constraints and native interaction patterns of each.
  • Deep Accessibility Expertise: Thorough knowledge of WCAG standards and a proven track record of baking accessibility and inclusive design principles into the core of a design system from day one.
  • Rapid Prioritization & Decisiveness: The ability to navigate ambiguity, weigh complex architectural trade-offs quickly, and prioritize roadmap items that deliver the most immediate, scalable value to the broader team without slowing down momentum.
  • Technical Fluency: Deep understanding of front-end constraints and modern tooling. You have developed seamless handoff flows with engineering and have hands-on experience using AI-driven design ops (like Figma MCP servers or AI IDEs) to tweak code, manage variables, and automate documentation directly.
  • Mission-Driven Leadership: A history of proactively taking the lead on complex initiatives, making the team around you stronger, and guiding projects across the finish line with speed, low ego, and a passion for building technology that genuinely helps people.
  • This remote opportunity based out of the U.S. Applicants must be authorized to work for any employer in the U.S. We are unable to sponsor or take over sponsorship of an employment Visa at this time.
Responsibilities
  • Architect the Company's Future: Play a critical role in defining the long-term trajectory of Twin Health's product design system. You aren't just building a system for today; you are creating the strategic blueprint that will support our next decade of growth.
  • Speed & Bias for Action: In our fast-paced environment, you will drive rapid iteration and deployment, expertly balancing high-velocity execution with long-term architectural integrity.
  • Establish System Governance: Define and maintain clear contribution models, documentation standards, and version control processes so the broader design team can easily adopt, contribute to, and scale the system at a rapid pace without creating fragmentation.
  • Exceptional Execution & Craft: Uphold an uncompromisingly high bar for visual design. You know exactly how design patterns impact the broader UX, ensuring that our system is as beautiful, accessible, and inclusive as it is functional. You can independently generate and land on a compelling visual direction from scratch.
  • Drive & Measure Adoption: Partner with engineering and product leaders to champion system adoption across the organization. You will be responsible for metrics to measure the system's impact on product quality, engineering velocity, and overall user experience to ensure design translates to real-world results.
  • Bridge Design, Code, & AI: Seize the chance to reinvent the bridge between our design and engineering teams. You will be empowered to forge entirely new operational flows, standing at the forefront of industry innovation by safely leveraging AI and Model Context Protocols (MCP) to automate and translate Figma environments directly into production code.
  • Strategic Collaboration & Trade-offs: Be a relentlessly open and communicative partner. While you are highly autonomous in driving visual direction and moving quickly, you also know how to collaborate deeply, when to pull back, and how to make the necessary architectural trade-offs to keep cross-functional projects moving forward.
  • Other duties as assigned

Twin Health uses a Whole Body Digital Twin to monitor metabolism and guide personalized treatment for chronic metabolic diseases like diabetes. The platform gathers data from sensors, builds a real-time virtual model of a person’s metabolism, and uses AI to suggest individualized care, with ongoing coaching and updates. It differentiates itself by targeting the root metabolic dysfunction with a continuous, data-driven twin and by forming partnerships with healthcare providers and payers for integrated care. The goal is to reverse and prevent metabolic diseases by restoring healthy metabolism through scalable, subscription-based care.

Company Size

501-1,000

Company Stage

Series E

Total Funding

$286.5M

Headquarters

Mountain View, California

Founded

2018

Simplify Jobs

Simplify's Take

What believers are saying

  • Series E funding of $53M at $950M valuation enables scaling across employers and health plans.
  • Peloton partnership integrates personalized fitness content, expanding member engagement and retention.
  • Healthy Weight program addresses obesity without GLP-1 medications, capturing growing weight loss market.

What critics are saying

  • One Health's single blood test delivers equivalent metabolic insights at lower cost and friction.
  • Levels Health and Nutrisense CGM programs commoditize digital twin IP with cheaper subscription alternatives.
  • OpenAI consumer metabolic AI model enables free apps replicating Twin Health recommendations, collapsing revenue.

What makes Twin Health unique

  • 90%+ Type 2 Diabetes reversal with A1C below 6.5% versus industry benchmark of 8.0%.
  • Whole Body Digital Twin integrates wearable sensors, ML, and clinical coaching for personalized metabolic interventions.
  • Delivers $8K+ annualized savings per member through medication deprescribing and reduced medical utilization.

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Your Connections

People at Twin Health who can refer or advise you

Benefits

Health Insurance

Dental Insurance

Vision Insurance

401(k) Retirement Plan

Unlimited Paid Time Off

Parental Leave

Health Savings Account/Flexible Spending Account

Company Equity

Remote Work Options

Flexible Work Hours

Growth & Insights and Company News

Headcount

6 month growth

1%

1 year growth

1%

2 year growth

0%
Athletech News
Oct 14th, 2025
Peloton's Newest Tech Bet: AI Digital Twins

Peloton's newest tech bet: AI Digital twins. Utilizing its digital twin technology, Twin Health will incorporate Peloton's content library to recommend personalized workouts to members based on their unique profiles. A new partnership between Peloton and Twin Health is uniting the breakthrough technology of digital twins and fitness. The healthtech company will now integrate the fitness brand's content to integrate Peloton's library of live and on-demand classes with Twin Health's hyper-personalized AI digital twin care plan, the latest innovation in personalized wellness. Here's how that digital twin works: Twin Health's technology creates a real-time model of your unique metabolism, drawing upon data from smart devices, lab results and meal logs. That model then provides personalized guidance on nutrition, movement, sleep and more, with the support of a clinical team. With the help of Peloton, the AI digital twin will recommend specific workouts or content based on a member's personalized metabolic health goals. That could look like low-impact cardio for a member focused on heart health, yoga for stress management or meditation to boost sleep quality. The partnership arrives soon after a study published in the New England Journal of Medicine Catalyst found Twin Health's AI Digital Twin to be an effective treatment for diabetes and weight loss without medications. Twin members will receive a Peloton App One membership at no additional cost, with the option to add a reduced-cost Peloton Bike+ rental or a Peloton All-Access membership. "At Peloton, we have long held that movement is medicine. Our interest in improving people's health outcomes is about putting that belief into action at scale, which we can accomplish with Twin Health," said senior vice president and general manager of Peloton for Business, Greg Hybl. "Together, we are pairing connected fitness and wellness with clinical care to unlock life-changing health outcomes for more people than ever before."

FinSMEs
Aug 22nd, 2025
Twin Health Raises $53M in Series E Funding Round

Twin Health raises $53M in Series E funding round.

Fortune
Aug 21st, 2025
Twin Health raises $53M Series E

Twin Health, a metabolic health startup, raised $53 million in a Series E funding round, reaching a valuation of over $950 million. The round was led by Maj Invest, with participation from Iconiq and Temasek. Twin Health's digital twin technology, which helps manage diabetes and other metabolic disorders, has shown promising results, with 71% of study participants lowering their A1C levels and often stopping medication. The company aims to scale commercially across more employers and health plans.

Yahoo Finance
Aug 21st, 2025
Exclusive: Twin Health, metabolic health startup, raises $53 million Series E at $950 million valuation

Twin Health raised a $53 million Series E led by Maj Invest of Denmark, Fortune has exclusively learned.

Sabko Milegi
Nov 11th, 2024
Join Twin Health as a Salesforce Developer - India

Join Twin Health as a Salesforce Developer - India.