Postdoctoral Research Fellow
Cincinnati Children’s Hospital and Medical Center
Postdoctoral Research Fellow
Cincinnati Children’s Hospital and Medical Center
Pediatric hospital, research, and medical education
Primary Location
Location SDepartment
ImmunobiologyShift
Day (United States of America)Schedule
Full timeWeekly Hours
40FTE
1Employee Status
RegularPosition Summary
The Grimes Lab at Cincinnati Children’s Hospital Medical Center is seeking a highly motivated Postdoctoral Fellow to join a collaborative research program focused on hematopoiesis, response to infection, and molecular oncology.
Led by H. Leighton “Lee” Grimes, PhD, the lab investigates the molecular and cellular mechanisms that regulate normal and malignant hematopoiesis, with particular emphasis on myelopoiesis, bone marrow failure syndromes, myelodysplastic syndromes (MDS), severe congenital neutropenia (SCN), and acute myeloid leukemia (AML).
Our goal is to uncover fundamental biological and molecular mechanisms underlying these diseases and translate those discoveries into new opportunities for therapeutic intervention.
Research Opportunities
The successful candidate will have the opportunity to conduct innovative research using established and emerging approaches, including:
A particular strength of the program is its integration of wet-lab experimental biology with computational and bioinformatics approaches. Through collaboration and mentorship with Nathan Salomonis, PhD, trainees have opportunities to develop expertise in analyzing complex single-cell and multi-omics datasets.
Research Environment
The Grimes Lab has a strong track record of developing and applying innovative approaches to hematopoietic biology. The laboratory has established multiple mouse models of human disease, including AML and SCN, and has contributed to advances in understanding hematopoietic differentiation, RNA splicing, epigenetic regulation, and disease-associated mutations.
In collaboration with the Salomonis Lab, the team also develops biologically focused informatics tools and workflows for the analysis and visualization of single-cell data.
Postdoctoral fellows will work in a highly collaborative, multidisciplinary environment that provides opportunities to build expertise in both experimental and computational research while contributing to discoveries with potential therapeutic relevance.
Qualifications
Candidates should have:
Experience with mouse models, molecular biology techniques, single-cell sequencing, genomics, epigenetics, computational biology, or bioinformatics is desirable.
Training and Professional Development
The position provides opportunities to:
About the Grimes Lab
The Grimes Lab is committed to developing a comprehensive understanding of normal and malignant hematopoiesis and using those insights to identify new approaches to treating hematologic disease. The lab’s work spans basic biology, disease modeling, genomics, bioinformatics, and therapeutic development, providing postdoctoral fellows with a multidisciplinary environment for scientific training and career development.
MAJOR DUTIES AND RESPONSIBILITIES:
Required:
About Us
At Cincinnati Children’s, we come to work with one goal: to make children’s health better. We believe in a holistic team approach, both in caring for patients and their families, and in advancing science and discovery. We strive to do better and find energy and inspiration in our shared purpose. If you want to be the best you can be, you can do it at Cincinnati Children’s.
Cincinnati Children's is:
Recognized by U.S. News & World Report as a top 10 best Children's Hospitals in the nation for more than 15 years
Consistently among the top 3 Children's Hospitals for National Institutes of Health (NIH) Funding
Recognized as one of America’s Best Large Employers (2025), America’s Best Employers for New Grads (2025)
One of the nation's America’s Most Innovative Companies as noted by Fortune
Consistently certified as great place to work
A Leading Disability Employer as noted by the National Organization on Disability
Magnet® designated for the fourth consecutive time by the American Nurses Credentialing Center (ANCC)
We Embrace Innovation—Together. We believe in empowering our teams with the tools that help us work smarter and care better. That’s why we support the responsible use of artificial intelligence. By encouraging innovation, we’re creating space for new ideas, better outcomes, and a stronger future—for all of us.
Comprehensive job description provided upon request.
Cincinnati Children’s is proud to be an Equal Opportunity Employer committed to creating an environment of dignity and respect for all our employees, patients, and families. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, genetic information, national origin, sexual orientation, gender identity, disability or protected veteran status. EEO/Veteran/Disability
Pediatric hospital, research, and medical education
Cincinnati Children’s Hospital Medical Center is a nonprofit academic medical center that provides pediatric care across the spectrum—from routine well-child visits to treatment of rare and complex illnesses—and serves as the Department of Pediatrics for the University of Cincinnati College of Medicine. Care is delivered by pediatric specialists in hospital and clinic settings, while researchers and educators translate findings into better treatments and train residents and fellows. It differentiates itself by combining patient care with university-backed pediatric research and education at scale, along with a commitment to equality and an inclusive environment for staff, patients, and families. Its goal is to improve child health by delivering high-quality care, advancing medical knowledge through research, and training the next generation of pediatric professionals.
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