Praxis Precision Medicines

Praxis Precision Medicines

Clinical-stage biopharma developing CNS therapies

Medical Science Liaison - Epilepsies

Full-Time
$145k - $175k/yr
Mid
PharmD, PhD, MD
Remote in USA
Remote

Field-based role requiring approximately 60–80% travel.

About the job

Requirements
  • An advanced clinical or scientific degree such as PharmD, PhD, MD, NP, PA, or RN is required.
  • Early- to mid-career experience in medical affairs, clinical practice, clinical research, or related biotech/pharmaceutical roles is required.
  • Ability to learn and communicate scientific and clinical information clearly and credibly is required.
  • Ability to build professional relationships with healthcare providers is required.
  • Interest in developing field-based expertise, including insight gathering and scientific engagement, is required.
  • Ability to manage multiple priorities with strong organization and attention to detail is required.
  • Willingness to travel extensively, approximately 60–80%, is required.
Responsibilities
  • Build and maintain scientific relationships with healthcare professionals, investigators, and key opinion leaders at defined priority academic and community neurology centers.
  • Deliver accurate, balanced, and compliant scientific exchange on disease state, clinical data, and the relutrigine clinical profile, including complex discussions in rare and genetic epilepsies.
  • Support pre-launch medical readiness by educating stakeholders on emerging data, evolving treatment paradigms, and patient identification considerations in SCN2A and SCN8A populations.
  • Engage in scientific dialogue on mechanism of action, genotype–phenotype relationships, and clinical data interpretation in rare patient populations.
  • Gather, synthesize, and communicate field insights, including unmet needs, diagnostic challenges, treatment patterns, and clinical questions, to inform medical strategy.
  • Support identification and engagement of key experts and specialized epilepsy centers under the guidance of senior team members.
  • Collaborate cross-functionally with internal teams to ensure aligned execution of field activities and support clinical readiness.
  • Represent Praxis at scientific congresses and medical meetings, capturing and translating insights into actionable recommendations.
  • Maintain up-to-date knowledge of rare epilepsy landscapes, clinical data, and emerging scientific developments.
  • Ensure all field activities comply with regulatory requirements, company policies, and industry standards.
Desired Qualifications
  • Experience in neurology or central nervous system disorders is preferred.
  • Exposure to payer and market access concepts is a plus.
  • Candidates with prior field-based experience and a demonstrated track record of independently driving site performance, influencing investigators, and improving trial execution may be considered at a higher level.

About the company

Praxis Precision Medicines

Praxis Precision Medicines

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Praxis Precision Medicines develops therapies for central nervous system (CNS) disorders, with a focus on conditions caused by neuronal imbalance and genetic epilepsies. Its products aim to restore balance in CNS networks by applying genetic epilepsy insights, progressing through clinical development toward potential commercialization. What sets Praxis apart is its commitment to patient-guided development, incorporating patient and caregiver needs into therapy design, alongside strategic partnerships with other healthcare entities. The company's goal is to deliver effective CNS treatments to patients and caregivers and advance collaborations that support clinical development and eventual market access.

Company Size

201-500

Company Stage

IPO

Headquarters

Cambridge, Massachusetts

Founded

2015

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Simplify's Take

What believers are saying

  • Praxis ended June 30, 2026 with $1.4 billion, funding operations into 2028.
  • FDA mid-cycle reviews found no major safety or efficacy concerns and skipped advisory committees.
  • Ulixacaltamide and relutrigine carry Breakthrough Designation; relutrigine also holds Orphan status.

What critics are saying

  • Relutrigine’s PDUFA slipped to December 27, 2026 after FDA review delay.
  • POWER1 missed its primary endpoint on June 1, 2026, weakening vormatrigine confidence.
  • Trade-secret litigation against ex-advisor Goldstein reached court on September 3, 2026.

What makes Praxis Precision Medicines unique

  • Praxis translates genetic epilepsy insights into CNS drugs targeting neuronal imbalance.
  • Two NDAs, ulixacaltamide and relutrigine, reached FDA review in 2026.
  • The Remagine Labs patch partnership extends ulixacaltamide beyond an oral-only franchise.

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Benefits

Health Insurance

Dental Insurance

Vision Insurance

Life Insurance

Disability Insurance

401(k) Company Match

Stock Options

Company Equity

Performance Bonus

Unlimited Paid Time Off

Paid Holidays

Flexible Work Hours

Growth & Insights and Company News

Headcount

6 month growth

↓ -5%

1 year growth

↓ -8%

2 year growth

↓ -6%
Innovation Victoria
Sep 21st, 2026
Investment Update: Remagine Labs Closes Seed Round

Remagine Labs is the latest Victorian success story to emerge from the University Innovation Platform (UIP), progressing from university-backed innovation into venture-backed growth. Following early support through the platform, the medtech company has secured a seed funding round led by Praxis Precision Medicines, with Innovation Victoria following on its initial UIP investment alongside Monash University.

Yahoo Finance
May 17th, 2026
FDA accepts Praxis Precision Medicines NDAs amid $92.6M Q1 loss and cash runway to 2028

Praxis Precision Medicines reported a first-quarter 2026 net loss of $92.56 million whilst confirming FDA acceptance of New Drug Applications for ulixacaltamide in Essential Tremor and relutrigine in SCN2A/SCN8A epileptic encephalopathies. Target action dates are set for 2026 and 2027 respectively. The regulatory milestones advance two programmes into formal FDA review alongside ongoing trials for vormatrigine and elsunersen. The company maintains a cash runway into 2028 as it concentrates resources on its central nervous system pipeline. The narrative projects $724.1 million revenue and $89.5 million earnings by 2029, requiring 359.5% yearly revenue growth. Analysts' forecasts yield a $449.13 fair value, representing 31% upside to current prices, though the most optimistic projections estimate $2.1 billion revenue by 2029.

Yahoo Finance
May 12th, 2026
Wedbush raises Praxis Precision Medicines price target to $166 despite underperform rating

Wedbush maintained an "Underperform" rating on Praxis Precision Medicines, Inc. (NASDAQ:PRAX) whilst raising its price target from $130 to $166, citing concerns about the ulixacaltamide filing and valuation. The FDA has accepted new drug applications for ulixacaltamide and relutrigine, with PDUFA dates of 29 January 2027 and 27 September 2026. Chief executive Marcio Souza said the company is positioning for two US launches within eight months. The clinical-stage biopharmaceutical company reported a net loss of $92.6 million for the quarter ending 31 March 2026. It holds approximately $1.4 billion in cash and investments, extending its financial runway into 2028. Additional clinical readouts are expected in 2026.

Yahoo Finance
May 3rd, 2026
Praxis ties executive pay to ulixacaltamide progress after 283% share gain and $567M raise

Praxis Precision Medicines has scheduled its 2026 annual meeting for 10 June to vote on director elections, auditor ratification and a Say-on-Pay proposal. The biotech company reported positive Phase 3 data for ulixacaltamide in essential tremor and filed an early new drug application. Praxis is implementing performance-based restricted stock units following a year that included a $567.1 million follow-on offering and a 283% share price gain. Vanguard Capital Management has taken a stake exceeding 5%, signalling institutional interest in management's incentive alignment. The company's narrative projects $724.1 million revenue and $89.5 million earnings by 2029, requiring 359.5% yearly revenue growth. Key near-term catalysts include FDA review of ulixacaltamide, whilst ongoing losses and potential dilution remain investor concerns.

Yahoo Finance
Mar 13th, 2026
Biotech Praxis secures $80.5M investment from Driehaus as stock soars 685% ahead of dual FDA filings

Driehaus Capital Management has invested $80.5 million in Praxis Precision Medicines, purchasing 432,510 shares and bringing its stake to 1.87% of assets under management. The transaction, disclosed on 17 February 2026, increased Driehaus's position value by $248.5 million, reflecting both the purchase and share price appreciation. Praxis shares have surged 685% over the past year to $303.37, giving the company an $8.4 billion market capitalisation. The biotech firm recently submitted two FDA applications: ulixacaltamide for essential tremor and relutrigine for rare developmental epilepsies. CEO Marcio Souza estimates the company's four late-stage programmes could generate over $20 billion in revenue if commercialised. Praxis ended 2025 with $926 million in cash and raised an additional $621 million in January, providing funding through 2028.