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Human Longevity

Human Longevity

Genomics-driven data platform for personalized health

Applied AI Engineer - Multiple Teams

Full-Time
No salary listed
Mid
South San Francisco, CA, USA
In Person

About the job

Requirements
  • Four or more years of experience building software, artificial intelligence, machine learning, or data-driven applications within healthcare, life sciences, biotechnology, genomics, diagnostics, digital health, or clinical environments.
  • Direct experience working with healthcare data, including clinical records, laboratory data, genomics data, imaging reports, physician documentation, patient communications, or healthcare operational workflows.
  • Strong understanding of healthcare terminology, clinical workflows, and the practical challenges of deploying artificial intelligence solutions in healthcare settings.
  • Proven experience building and deploying production artificial intelligence applications.
  • Hands-on experience with Large Language Models and modern artificial intelligence application development.
  • Experience with Retrieval-Augmented Generation, agentic artificial intelligence systems, prompt engineering, and workflow automation.
  • Ability to identify business problems and rapidly build solutions with a strong product mindset.
  • Experience deploying systems used by real customers, clinicians, patients, or operational teams.
  • Strong proficiency in Python.
  • Experience with SQL and modern database technologies.
  • Experience with APIs, integrations, and distributed systems.
  • Familiarity with cloud platforms and modern software engineering practices.
  • Strong understanding of software architecture, testing, and deployment.
Responsibilities
  • Design, build, and deploy AI-powered applications from concept to production.
  • Rapidly prototype new ideas and transform them into production-ready systems.
  • Partner directly with clinicians, operators, and business stakeholders to identify high-value opportunities.
  • Deliver solutions that create measurable operational, clinical, or member-facing impact.
  • Design and deploy autonomous and semi-autonomous AI agents.
  • Implement multi-agent workflows that automate complex healthcare processes.
  • Evaluate and integrate modern agent frameworks and orchestration platforms.
  • Build AI assistants that support clinical operations, member engagement, and internal productivity.
  • Build applications leveraging state-of-the-art Large Language Models.
  • Develop Retrieval-Augmented Generation systems across structured and unstructured healthcare data.
  • Optimize prompts, workflows, evaluation systems, and agent behavior.
  • Implement knowledge retrieval systems across clinical, genomic, imaging, and operational data.
  • Build scalable data pipelines and AI services.
  • Create reusable AI components, APIs, and internal platforms.
  • Improve the reliability, observability, performance, and security of AI systems.
  • Support deployment and monitoring of production AI applications.
  • Take ownership from idea through production deployment.
  • Work cross-functionally with engineering, clinical, operations, and leadership teams.
  • Continuously evaluate and improve AI solutions based on real-world outcomes.
Desired Qualifications
  • Experience with genomics, precision medicine, longevity medicine, radiology, pathology, or advanced diagnostics.
  • Experience with healthcare interoperability standards such as FHIR and HL7.
  • Experience building clinician-facing AI products.
  • Experience building patient-facing AI assistants.
  • Experience with healthcare privacy, security, and compliance requirements.
  • Startup or high-growth technology company experience.
  • Experience with OpenAI, Anthropic, Gemini, or similar foundation models.
  • Experience with LangGraph, LangChain, CrewAI, AutoGen, or PydanticAI.
  • Experience with vector databases, enterprise search systems, agent orchestration platforms, or workflow automation tools.

About the company

Human Longevity is a biotech company focused on genomics and data-driven insights to improve healthspan and lifespan. It aims to build the world’s largest database of human genotypes and phenotypes, integrating advanced technology to predict and prevent diseases. Founded in 2013 by Craig Venter, Peter Diamandis, and Robert Hariri, it has pursued significant funding rounds (e.g., $70M in 2014 and $220M Series B in 2017) to accelerate research and development. The company has faced scaling and commercialization challenges but continues to work on applying genomic data to personalized healthcare.

Company Size

51-200

Company Stage

Late Stage VC

Total Funding

$359.8M

Headquarters

San Diego, California

Founded

2013

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Simplify's Take

What believers are saying

  • The August 2026 $599 nationwide sequencing launch expands reach far beyond clinic memberships.
  • Insilico collaboration and Geoffrey Hinton's 2026 advisory role strengthen credibility with investors and customers.
  • LEV Foundation and centenarian studies create new proprietary datasets for aging biomarkers.

What critics are saying

  • The $599 genome test commoditizes its core offering and erodes clinic-margin differentiation.
  • No peer-reviewed clinical outcomes validate its disease-prediction claims, inviting regulatory scrutiny before 2027.
  • Its business still depends on a tiny affluent customer base in South San Francisco.

What makes Human Longevity unique

  • Human Longevity owns a decade-long, de-identified dataset from 10,000-plus clients.
  • It bundles whole-genome sequencing, imaging, biomarkers, and clinician-guided longevity assessments.
  • The May 2026 HLFM launch with Insilico gives it rare AI-longevity branding.

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Benefits

Stock Options

Growth & Insights and Company News

Headcount

6 month growth

-1%

1 year growth

-2%

2 year growth

-1%
AVNation
Aug 12th, 2026
Extron and AV Structural streamline AV for high-performance medical clinic.

Extron and AV Structural streamline AV for high-performance medical clinic. August 12, 2026 Extron and AV Structural have delivered a unified, standards-based AV solution for Human Longevity's advanced medical clinic in South San Francisco, enabling seamless support for video conferencing, patient consultation, medical imaging, and digital content delivery across the entire facility. Designed to complement the clinic's focus on precision wellness and personalized care, the system leverages Extron DTP CrossPoint Series scaling presentation matrix switchers to provide centralized signal routing, integrated control, and consistent user experiences across diverse spaces, including consultation rooms, imaging suites, executive offices, and public areas. Despite a compressed timeline and evolving construction conditions, the Extron platform enabled efficient deployment and cohesive performance throughout the project. "Extron's technical and sales support made a huge difference," said Teo Nguyen, Senior Systems Engineer/Programmer at AV Structural. "With deadlines tight and logistics changing daily, having direct access to people who could get us answers and hardware quickly was critical. The system we delivered gives Human Longevity what they need today, and it's built to grow with them as their clinic evolves." The installation includes Extron DTP 4K transmitters and receivers, TouchLink Pro touchpanels, and TLS 1025M scheduling panels to streamline room control and coordination while preserving patient privacy. An Extron DMP 64 Plus digital matrix processor manages audio across a facility-wide 70-volt distribution system, while XPA U and MPA Series amplifiers and SF 3CT LP SoundField ceiling speakers deliver clear, consistent sound. Occupancy sensors automate room behavior, enabling intuitive operation and reducing staff interaction with technology. The result is an integrated AV environment that supports efficient workflows, enhances communication, and reinforces a modern, technology-driven patient experience. Recent comments. Avnation is supported by. - Advertisement -

PR Newswire
May 27th, 2026
Human Longevity and Insilico Medicine partner to build first AI foundation model for longevity science

Human Longevity has launched Human Life Foundation Models, Inc. (HLFM) to develop large-scale foundation models for longevity science, partnering with Insilico Medicine in a multi-year, multi-million dollar collaboration. The venture targets the global longevity market, which UBS estimates will grow from $5.3 trillion to nearly $8 trillion by 2030. HLFM will combine Human Longevity's decade-long collection of genomic, imaging and clinical data with Insilico Medicine's AI technologies to build foundation models predicting disease risk and understanding ageing biology. The collaboration uses privacy-preserving architecture where patient data remains with original custodians and is not transferred across institutions. The models aim to enable early disease detection, predictive health risk modelling and personalised longevity interventions, shifting medicine from treatment to prevention.

Dailyhunt
May 26th, 2026
Insilico Medicine and Human Longevity announce collaboration to co-develop industry-first AI foundation model for longevity science.

Insilico Medicine and Human Longevity announce collaboration to co-develop industry-first AI foundation model for longevity science. 1 hour ago Cambridge, Mass., May 26, 2026 /PRNewswire/ - Insilico Medicine ("Insilico", 3696.HK), a clinical-stage generative artificial intelligence (AI)-driven biotechnology company, and Human Life Foundation Models, Inc. (HLFM), a newly launched company established by Human Longevity, Inc. today announced a multi-million-dollar AI co-development collaboration to build industry's first large-scale foundation models dedicated to human longevity science. As aging populations reshape global labor markets and consumer demand, longevity has transcended its origins as a niche scientific pursuit to become a major economic pillar. According to recent analysis by UBS, the global longevity market is currently valued at approximately $5.3 trillion and is on a trajectory to reach $8 trillion by 2030. Propelling this evolution is AI-driven drug discovery, which has emerged as a cornerstone of aging research by modeling aging biology, predicting disease risk, and accelerating the discovery of preventive and therapeutic interventions to extend healthy human lifespan. The collaboration between Insilico and HLFM aims to jointly develop a super-intelligence AI foundation model to decode the biological mechanisms of aging and enable predictive healthcare. Within this framework, Insilico will leverage its expertise in multimodal foundation model development and deep learning system engineering, building on the advanced training and evaluation capabilities of MMAI Gym to systematically deliver model architecture, benchmarking, training guidelines, and computational algorithms, providing the technical foundation for the jointly developed model. Human Life Foundation Models will integrate these tools and capabilities with Human Longevity's unique, de-identified multi-omic and clinical datasets to build advanced multimodal AI models. Drawing from over a decade of research, Human Longevity has curated one of the world's most comprehensive integrated datasets, spanning multi-omics, imaging, and longitudinal health records from thousands of individuals. By leveraging this vast repository, HLFM will support the foundation models' cognitive training, enabling the system to detect, diagnose, and manage patient conditions with clinical-grade precision. By fusing these advanced algorithms with deep biological insights, the jointly developed foundation models are expected to be commercially available to drive breakthroughs in the early detection of age-related diseases, predictive health risk modeling, and the discovery of novel AI-driven therapeutics and personalized interventions to extend healthy human lifespan. The companies believe that these advancements will play a pivotal role in the future of medicine by shifting the global healthcare paradigm from reactive disease treatment toward proactive and preventive longevity science. "By combining Insilico's expertise in generative AI drug discovery and multimodal foundation models with HLFM's unique datasets, and conducting rigorous model training and benchmark evaluation under the advanced MMAI Gym framework, we aim to build a next-generation AI system capable of decoding the biology of aging," said Alex Zhavoronkov, Founder, CEO and CBO of Insilico Medicine. "Human longevity and healthspan represent one of the most complex challenges in biology. This collaboration is about creating a true foundation model for human health that can identify disease risks earlier, uncover novel therapeutic targets, and accelerate the discovery of longevity therapeutics with unprecedented precision." "Human Longevity was founded with the vision that large-scale biological data combined with artificial intelligence would fundamentally transform medicine," said Wei-Wu He, Executive Chairman of Human Longevity. "By having HLFM partnering with Insilico Medicine to build the human life foundation models, we are taking a major step toward creating a true foundation model for human health and longevity - one that can help predict complex disease decades before it occurs and guide interventions to extend healthy lifespan." Longevity has been central to Insilico's mission since its inception. The company's journey gained industry notice in 2015 at the NVIDIA GTC conference, where Alex Zhavoronkov, PhD, founder and CEO of Insilico, challenged the tech world with a provocative question: "Can NVIDIA cure aging?". Recently, Insilico announced the industry's first longevity board composed of high-profile scientists and chaired by Andrew Adams, PhD, Group Vice President of Molecular Discovery at Eli Lilly and Company to accelerate AI-Driven aging research for drug discovery. Insilico has published over 50 research papers related to aging and longevity research, biomarkers of aging, therapeutic targets and therapeutics implicated in aging, longevity and disease since 2014. About Insilico Medicine Insilico Medicine is a pioneering global biotechnology company dedicated to integrating artificial intelligence and automation technologies to accelerate drug discovery, drive innovation in the life sciences, and extend healthy longevity to people on the planet. The company was listed on the Main Board of the Hong Kong Stock Exchange on December 30, 2025, under the stock code 03696.HK. By integrating AI and automation technologies and deep in-house drug discovery capabilities, Insilico is delivering innovative drug solutions for unmet needs including fibrosis, oncology, immunology, pain, and obesity and metabolic disorders. Additionally, Insilico extends the reach of Pharma.AI across diverse industries, such as advanced materials, agriculture, nutritional products and veterinary medicine. For more information, please visit www.insilico.com About Human Life Foundation Models (HLFM) Human Life Foundation Models, Inc. (HLFM) is focused on developing multimodal AI foundation models for human health and longevity by integrating large-scale biological, clinical, imaging, and longitudinal health data with advanced artificial intelligence systems. About Human Longevity, Inc. Founded in 2013, Human Longevity, Inc. integrates genomics, artificial intelligence, and multimodal diagnostics to extend human healthspan through proactive diagnostics and personalized preventive care. To learn more, visit Human Longevity.

PR Newswire
May 11th, 2026
Human Longevity launches $599 whole genome sequencing with AI insights for disease prevention

Human Longevity has launched a clinical-grade whole genome sequencing report for $599, combining AI-enhanced insights for disease prevention. The service honours the legacy of Dr J. Craig Venter, whose work helped decode the first human genome over two decades ago at a cost exceeding $3 billion. Founded in 2013 by Venter, the South San Francisco-based company has invested over $600 million building a longitudinal health dataset from more than 10,000 individuals over 10 years. The platform uses proprietary AI to provide insights on inherited disease risks, carrier status, pharmacogenomics and longevity traits, focusing on age-related chronic diseases including cardiovascular disease, cancer and dementia. The service is available nationwide immediately through Human Longevity's website.

PR Newswire
Apr 10th, 2026
Nobel laureate Geoffrey Hinton joins Human Longevity as AI advisor to guide disease prediction platform

Human Longevity, Inc. has appointed AI pioneer and Nobel laureate Geoffrey Hinton to its Scientific Advisory Board. Dr Hinton, who won the 2024 Nobel Prize in Physics for his foundational work in machine learning and neural networks, will guide the company's AI strategy for disease-risk prediction and early detection. The South San Francisco-based precision health company has spent over a decade building a comprehensive longitudinal dataset integrating genomics, advanced imaging and multi-omic biomarkers. Human Longevity launched its AI-powered Longevity App, MyHealth, in early 2026. "I believe AI will fundamentally transform healthcare," said Hinton. "Human Longevity is uniquely positioned to lead this transformation through its integration of large-scale genomic, imaging and biomarker data with advanced machine-learning approaches.