Research Assistant to Associate Scientist - Pharmacology

Job responsibilities: 

1. Animal model and in vivo experiment support: Under the guidance of the project leader and team, participate in the establishment, optimization and daily maintenance of experimental animal disease models; Perform animal drug administration, sampling and related in vivo experimental operations according to the experimental plan; Assist in communicating with CROs and relevant departments within the company to support the promotion of drug development projects.

2. Cell biology experiments: Carry out cell-level research under the guidance, including cell culture, passaging, cryopreservation, gene transfection, and construction of basic functional cell models, for pharmacology evaluation and mechanism research.

3. Molecular biology experiments: Participate in routine molecular biology experiments, such as ELISA, qPCR, Western Blot, etc., and complete experimental operations, raw data recording, and basic results according to the established process.

4. Tissue sample processing and basic analysis: Assist in the collection and processing of animal tissue samples under standardized operating procedures, including hard tissue and paraffin tissue section preparation, immunohistochemical staining (IHC), conventional tissue staining, and in situ hybridization.

5. Experimental Records and Compliance Support: Standardize the recording of experimental processes and results, organize experimental data, and assist in completing experimental documents, reports, and related compliance materials.

6. Perform other tasks as assigned.

岗位职责： 

1. 动物模型与体内实验支持：在课题负责人及团队指导下，参与实验动物疾病模型的建立、优化与日常维护；按实验方案执行动物给药、取样及相关体内实验操作；协助与CRO及公司内部相关部门沟通，支持药物研发项目推进。

2. 细胞生物学实验：在指导下开展细胞水平研究工作，包括细胞培养、传代、冻存、基因转染及基础功能性细胞模型的构建，用于药效评价及机制研究。

3. 分子生物学实验操作：参与常规分子生物学实验，如ELISA、qPCR、Western Blot 等，按照既定流程完成实验操作、原始数据记录及基础结果整理。

4. 组织样本处理与基础分析：在规范操作流程下，协助完成动物组织样本的采集与处理，包括硬组织和石蜡组织切片制备、免疫组织化学染色（IHC）、常规组织染色及原位杂交等实验操作。

5. 实验记录与合规支持：规范记录实验过程与结果，整理实验数据，协助完成实验文档、报告及相关合规性材料。

6. 完成上级交办的其他任务。

Job Requirements: 

1. Educational background: Bachelor’s degree or above in biology, biotechnology, biomedicine, pharmacy, basic medicine or related majors;

2. Work experience:

Research Assistant: Bachelor’s degree with 2–3 years of relevant work experience or Master’s degree with 1 year of relevant work experience;

Associate Scientist: Bachelor’s degree with 4–7 years of relevant work experience or Master’s degree with 2-4 year of relevant work experience; 

3. Professional skills and experimental experience: mastering the basic principles of cell biology and molecular biology experiments; Experience in cell culture, passaging, cryopreservation and gene transfection is preferred. Familiar with conventional molecular biology experiments such as ELISA, qPCR, and Western Blot is preferred. Experience with laboratory animals (such as mice, cynomolgus monkeys, etc.) is preferred.

4. Basic Histology and Pathology: Knowledge of or exposure to tissue sample handling processes, including tissue fixation, dehydration, embedding, sectioning, tissue staining, or immunohistochemistry (IHC) is preferred.

5. Data recording and scientific research specifications: Have good experimental recording habits, be able to complete experimental operations and original data collation in accordance with SOP specifications and understand scientific research compliance and data traceability requirements. Proficient in Microsoft office software and statistical analysis software.

6. Communication, collaboration and learning ability: have good learning ability and sense of responsibility and be able to efficiently complete experimental tasks under guidance; Have a good sense of teamwork and communication skills and be able to collaborate smoothly with team members and relevant departments.

7. Work attitude and professionalism: serious and meticulous work, strong execution, and certain ability to withstand pressure; He has a strong interest in innovative drug research and development or biomedical research and is willing to develop in the direction of research and development for a long time.

8. English proficiency requirement: Good listening, reading and writing skills in English are desired; excellent spoken English is preferred.

任职要求： 

1. 教育背景: 生物学、生物技术、生物医学、药学、基础医学或相关专业，

2. 工作经验：研究助理：本科且具备2–3年相关工作经验者， 和硕士学历具备1年相关经验者。副研究员： 本科且具备4-7年相关工作经验者，或硕士具备2-4年相关经验者。

3. 专业技能与实验经验：掌握基础的细胞生物学与分子生物学实验原理；具备细胞培养、传代、冻存及基因转染等实验操作经验者优先；熟悉ELISA、qPCR、Western Blot等常规分子生物学实验者优先；有实验动物相关经验（如小鼠、食蟹猴等）者优先。

4. 组织学与病理学基础：了解或接触过组织样本处理流程，包括组织固定、脱水、包埋、切片、组织染色或免疫组织化学（IHC）等实验者优先。

5. 数据记录与科研规范：具备良好的实验记录习惯，能够按照SOP规范完成实验操作及原始数据整理，理解科研合规与数据可追溯性要求。熟练运用Microsoft办公软件及统计分析软件。

6. 沟通协作与学习能力：具备良好的学习能力与责任心，能够在指导下高效完成实验任务；具有良好的团队合作意识和沟通能力，能够与团队成员及相关部门顺畅协作。

7. 工作态度与职业素养：工作认真细致，执行力强，具备一定抗压能力；对创新药研发或生物医药研究具有浓厚兴趣，愿意长期在研发方向发展。

8. 英文能力要求：具有较好的英文听读和写作能力，口语优秀者优先。

Note: the final job title will be commensurate with the candidate’s seniority, skills and level of experience. 

注：最终岗位将根据候选人的工作年限、技能和经验水平综合确定。

About Angitia:

Established in June 2018, Angitia Biopharmaceuticals is a multinational research and development enterprise focusing on discovery and development of new drugs for grievous bone, muscle and joint diseases. The founder and the core team members of Angitia are seasoned scientific leaders in new drug discovery, development and management from both overseas and domestic large multinational companies. The company has built an organization distinguished by world-class scientists with talents that proficient in the pathophysiology of musculoskeletal diseases. We utilize cutting-edge technologies of genetics and molecular biology to uncover new mechanisms, signal transduction pathways and their interactions combined with computer aided drug design to identify new drug targets, and to discover and develop new biological and small molecule medicines. The company is committed to serving patients in need by carrying out innovative science includes internal research and external collaborations with academics and global biopharmaceutical companies. We are seeking people who are competent, ambitious and great team players to join our vibrant group.

Our mission is to discover, develop and commercialize breakthrough therapeutics that address the key unmet medical needs of serious musculoskeletal diseases.

Learn more at www.angitiabio.com.