Systimmune

Develops bispecific antibodies and ADCs

Executive Director - Finance

Corporate Finance & FP&AConfirmed live in the last 24 hours

Full-timeBothell, WA, USA$200k - $270k /yrIn-person

About the Job

Requirements

A bachelor's degree in Finance, Accounting, or a related field.
At least 12 years of progressive finance experience in biotech or pharma, with significant exposure to clinical development, research and development financial planning and analysis, and alliance finance in a biotech or biopharma company.
Demonstrated experience building and managing clinical trial budgets and overseeing vendor finances.
Strong understanding of global clinical development processes, clinical operations, and regulatory pathways consistent with expectations of clinical development leaders.
Strong analytical, financial modeling, communication, and stakeholder-management skills, attention to detail, and a proactive approach to problem-solving.
Experience working with external partners in alliance or co-development settings.
Ability to work effectively in a rapidly evolving, high-intensity setting, balance competing demands, and support time-sensitive initiatives that may require extended work hours.

Responsibilities

Manage alliance finance for partnered clinical programs, ensuring consistent budgeting, reporting, and cost-sharing in collaboration with external partners.
Provide joint program financial updates, coordinate budget alignment with partners, and ensure accurate execution of cost-sharing terms and financial governance.
Support cross-company working groups with transparent reporting, financial models, and documentation.
Lead the creation, review, and refinement of clinical trial budgets across all phases, aligning them with study design, timelines, and operational assumptions.
Develop detailed cost models, enrollment-driven forecasts, and operational expenditure projections for all clinical studies.
Partner with Clinical Operations, Medical, Regulatory, Drug Safety, Biometrics, and Program Management to ensure financial accuracy of trial-level assumptions.
Oversee financial aspects of contracts with CROs, laboratories, vendors, and other clinical service providers, ensuring competitive pricing, change-order management, and efficient use of clinical resources.
Oversee the finance team in invoice processing and manage invoice payments transparently and accurately.
Provide strategic financial guidance and decision support informed by clinical development plans and regulatory strategy.
Provide financial leadership for portfolio decision-making, scenario planning, risk assessment, and long-range clinical resource planning.
Oversee the clinical finance team in annual operating planning, quarterly forecasts, variance analyses, headcount planning, and functional financial reporting for the clinical development organization.
Deliver monthly reporting packages for research and development leadership and the executive team, including insights into trial spending, vendor accruals, study progression, and financial risks and opportunities.
Ensure compliance with internal financial policies and support audit requests related to clinical development spending.
Build and lead a high-performing clinical finance team with strong business partnership capabilities.
Improve financial processes, analytics, and tools to increase accuracy, efficiency, and visibility of clinical financial data.

Desired Qualifications

An MBA or advanced degree in Finance, Accounting, or a related field.
Familiarity with regulatory requirements and compliance standards in the biotech industry.
Demonstrated success managing projects in a fast-paced, dynamic environment.
Prior leadership experience and demonstrated career advancement in fast-growth biotech.
Ability to cultivate relationships across departments to enhance financial integration within the organization.
Willingness to work across time zones in a global business environment.

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Bothell, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success.

The Executive Director, Finance will serve as the business partner and the strategic finance leader supporting SystImmune’s global clinical programs. This role partners closely with Clinical Development, Clinical Operations, Alliance Management, Accounting, and senior executives to drive financial strategy, optimize resource allocation, provide robust forecasting, and ensure transparency of clinical trial costs. The leader will manage a team of finance professionals and have the accountability for end‑to‑end financial oversight of clinical development, including budgeting, trial cost modeling, vendor financial management, alliance finance, and FP&A support for the Clinical organization.

Key Responsibilities:
Alliance Finance

Manage alliance finance responsibilities for partnered clinical programs, ensuring consistent budgeting, reporting, and cost‑sharing in collaboration with external partners.
Provide joint program financial updates, coordinate budget alignment with partners, and ensure accurate execution of cost‑sharing terms and financial governance.
Support cross‑company working groups with transparent reporting, financial models, and documentation.

Clinical study budgeting and cost management

Lead creation, review, and refinement of clinical trial budgets across all phases, ensuring alignment with study design, timelines, and operational assumptions
Develop detailed cost models, enrollment‑driven forecasts, and operational expenditure projections for all clinical studies.
Partner with Clinical Operations, Medical, Regulatory, Drug Safety, Biometrics, and Program Management to ensure financial accuracy behind trial-level assumptions.
Oversee financial aspects of contracts with CROs, laboratories, vendors, and other clinical service providers, ensuring pricing competitiveness, change order management, and efficient use of clinical resources.
Oversee the finance team in invoice processing and manage invoice payment process with transparency and accuracy

Strategic leadership and FP&A

Provide strategic financial guidance and decision support informed by clinical development plans and regulatory strategy.
Provide financial leadership for portfolio decision‑making, scenario planning, risk assessment, and long‑range clinical resource planning.
Oversee the clinical finance team in annual operating planning, quarterly forecasts, variance analyses, headcount planning, and functional financial reporting for the clinical development organization.
Deliver monthly reporting packages for R&D leadership and the executive team, with insights into trial spend, vendor accruals, study progression, and financial risks/opportunities.
Ensure compliance with internal financial policies and support audit requests related to clinical development spend.

Team Leadership & Development

Build and lead a high‑performing clinical finance team with strong business partnership capabilities.
Champion continuous improvement of financial processes, analytics, and tools to improve accuracy, efficiency, and visibility of clinical financial data.

Qualifications:

Bachelor’s degree in Finance, Accounting, or a related field.
12+ years of progressive finance experience in biotech/pharma, with significant exposure to clinical development, R&D FP&A, and alliance finance in a biotech or biopharma company.
Demonstrated experience building and managing clinical trial budgets and vendor financial oversight.
Strong understanding of global clinical development processes, clinical operations, and regulatory pathways (consistent with expectations of clinical development leaders).
Exceptional analytical, modeling, communication, and stakeholder‑management skills, and attention to detail, with a proactive approach to problem-solving.
Experience working with external partners in alliance or co‑development settings.
Demonstrated ability to perform effectively in a rapidly evolving, high‑intensity work setting, including balancing competing demands and supporting time‑sensitive initiatives that may require extended work hours.

Preferred Qualifications:

MBA or advanced degree in Finance, Accounting, or a related field.
Familiarity with regulatory requirements and compliance standards in the biotech industry.
Demonstrated success in managing projects in a fast-paced, dynamic environment
Prior leadership and demonstrated career advancement in fast‑growth biotech
Ability to cultivate relationships across departments to enhance financial integration within the organization.
Willingness to work across time zones in a global business environment.

Compensation and Benefits:
The expected base salary range for this position is $200,000 - $270,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s qualifications, experience, and skills.
While most offers typically fall within the low to mid-point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.

SystImmune is a leading and well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.

We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.

SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.

About the Company

Systimmune

Develops bispecific antibodies and ADCs

Systimmune is a biopharmaceutical company that develops antibody-based cancer therapies, including bispecific and trispecific antibodies and antibody-drug conjugates (ADCs). These products are designed to act on the solid tumor micro-environment to directly attack tumors and/or to activate the immune system to fight cancer. The company uses multiple immuno-oncology platforms and experienced scientists to create biologics that intervene in the tumor environment in systematic ways. Compared with competitors, Systimmune emphasizes integrating several antibody-based modalities (bispecifics, trispecifics, and ADCs) and a deep focus on the solid tumor micro-environment, aiming to translate biological insight into targeted, immune-engaging therapies. The goal is to produce biologics that effectively modulate the tumor environment and mobilize the body's own immune response to destroy cancer cells.

Company size: 11-50
Company stage: Not listed
Total funding: Not listed
Headquarters: Redmond, WA
Founded: 2014

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