Rhythm Pharmaceuticals

Commercializes MC4R-targeted therapies for rare obesity

Federated Registry Data Scientist

Data ScienceConfirmed live in the last 24 hours

Full-timeNo salary listed

About the Job

Requirements

An advanced degree in Life Sciences, Data Science, Information Systems, or an equivalent scientific or technical discipline.
Strong experience with healthcare data sources, including clinical registries, electronic health records, claims databases, healthcare databases, and real-world evidence projects.
Strong proficiency in R and/or Python.
Knowledge of healthcare standards, including Observational Medical Outcomes Partnership Common Data Model, Fast Healthcare Interoperability Resources, and Systematized Nomenclature of Medicine Clinical Terms.
Knowledge of statistical methods in real-world evidence.
Fluency in English.
Willingness and ability to travel internationally.

Responsibilities

Contribute to the design, development, and operation of a multi-country federated registry platform based on the Observational Medical Outcomes Partnership Common Data Model, collaborating with specialized vendors for extract-transform-load, hosting, and federated analyses.
Serve as a primary point of contact between the company, selected vendors, and participating registries for data-related activities.
Oversee local registry data collection, including mapping, transformation, and quality checks, and oversee federated analysis specifications and outputs in the vendor-provided and maintained federated environment.
Oversee vendors’ technical and analytical deliverables.
Oversee data collection, data quality checks, extract-transform-load logic, and data mapping to the Observational Medical Outcomes Partnership Common Data Model.
Lead preparation and review of the statistical analysis plan, cohort definitions, variable definitions, and federated query specifications, based on research questions proposed by the Scientific Committee, participating centers, or internally, and supported and executed by vendors.
Assess the feasibility of external research proposals before Scientific Committee review.
Ensure analytical outputs are clear and consistent with research questions, develop reports for Scientific Committee review, and support drafting related publications.
Collaborate with vendors on source data review, Observational Medical Outcomes Partnership mapping, extract-transform-load logic, and data quality checks, helping identify, prioritize, and resolve quality issues.
Address data-related questions raised by vendors and coordinate timely responses from centers when local input is required.
Ensure data-related discussions remain aligned with the company’s scientific objectives, project scope, timelines, and budget.
Support sites in understanding project data requirements, minimum datasets, expected formats, timelines, and quality control processes.
Coordinate with sites and vendors to investigate data quality issues, including missing data, inconsistent values, and duplicate records.
Collaborate with research teams, including scientific committees, internal stakeholders, and participating sites, to develop insights and drive evidence generation.

Company Overview
Rhythm is a global, commercial-stage biopharmaceutical company committed to transforming the lives of patients living with rare neuroendocrine diseases. We develop medicines for previously untreatable or undertreated diseases. We recognize the courage it takes for patients and their caregivers to begin their journey of advocacy to find the answers they need. Their courage inspires us to challenge convention, ask bold questions and seek answers for them. Every day, we strive for excellence through our willingness to adapt, learn, and our tenacity to overcome barriers, together.

Opportunity Overview
The Federated Registry Data scientist will contribute to the design, development and operation of a multi-country federated registry platform based on the Observational Medical Outcomes Partnership Common Data Model (OMOP CDM), in collaboration with specialized vendors for Extract-Transform-Load (ETL), hosting, and federated analyses.
The role will serve as a primary point of contact between Rhythm, the selected vendors, and participating registries for data-related activities. The Data Scientist will oversee the local registry data collection (mapping, transformation, quality-check) and the federated analyses specifications and outputs within a federated OMOP CDM-based environment provided and maintained by the vendors.

Responsibilities & Duties

Federated analyses

Oversee and supervise the vendor’s technical and analytical deliverables
Oversee data collection, data quality check, ETL logic and data mapping to OMOP CDM
Lead preparation and review of the statistical analysis plan, cohort definitions, variable definitions, and federated query specifications supported and executed by the vendors based on research questions proposed by the Scientific Committee, the participating centers or internally
Perform external research proposals’ feasibility assessment before review by the Scientific Committee
Ensure analytical outputs are clear and consistent with research questions, develop report for review by the scientific committee, and support the drafting of related publications
Collaboration with vendors
Collaborate with the vendor on source data review, OMOP mapping, ETL logic, and data quality checks, helping to identify, prioritize, and resolve quality issues
Help with data-related questions raised by the vendor and coordinate timely responses from centers when local input is required
Ensure that data-related discussions remain aligned with Rhythm’s scientific objectives, project scope, timelines, and budget
Collaboration with sites/registries owners
Support sites in understanding project data requirements, minimum datasets, expected formats, timelines, and quality control processes
Coordinate with sites and the vendor to investigate data quality issues such as missing data, inconsistent values, duplicate records, etc.
Collaborate with research teams (scientific committees, internal stakeholders, participating sites) to develop insights and drive evidence generation
Perform any other relevant tasks as needed to support the team and company objectives.

Qualifications & Skills

Advanced degree in Life Sciences, Data Science, Information Systems, or an equivalent scientific or technical discipline
Strong experience with healthcare data sources, including clinical registries, electronic health records, claims databases, healthcare databases, and real-world evidence projects
Strong proficiency in R and/or Python
Knowledge of healthcare standards, including OMOP CDM, Fast Health Interoperability Resources (FHIR), Systemized Nomenclature of Medicine Clinical Terms (SNOMED CT), etc.
Knowledge of statistical methods in real-world evidence (RWE)
Strong communication and interpersonal skills, capable of engaging with senior leadership and key stakeholders.
Not accepting the status quo, working with a sense of urgency to deliver results
Self-starter mentality who feels comfortable working in a fast-paced environment
Cross-functional mindset focused on a seamless collaboration with internal and external partners
Fluent in English

This role is home office based. Rhythm operates in a hybrid-work model. Candidates applying must be willing and able travel internationally.

More about Rhythm
We are a dynamic and growing global team spanning more than a dozen countries. At Rhythm we are dedicated to transforming the lives of patients living with rare melanocortin-4 receptor (MC4R) pathway diseases by rapidly advancing care and precision medicines that address the root cause. Our team is passionate about expanding access to reach more patients and developing novel therapies for other rare neuroendocrine diseases, including congenital hyperinsulinism.

At Rhythm Our Core Values Are
We are committed to advancing scientific understanding to improve patients’ lives
We are inspired to tackle tough challenges and have the courage to ask bold questions
We are eager to learn and adapt
We believe collaboration and ownership are foundational for our success
We value the unique contribution each individual brings to furthering our mission
Inherent in our core values is the commitment to act ethically and with integrity in all we do.

About the Company

Rhythm Pharmaceuticals

Commercializes MC4R-targeted therapies for rare obesity

Rhythm Pharmaceuticals focuses on developing therapies for rare neuroendocrine genetic obesity disorders, led by IMCIVREE (setmelanotide). IMCIVREE is an MC4R agonist that restores signaling in the MC4R pathway to curb hunger and regulate energy use; it is FDA, EC, and MHRA approved for Bardet-Biedl syndrome and certain POMC/PCSK1/LEPR deficiencies in patients aged 2 and older, with revenue from global sales. The company differentiates itself by pursuing precision medicine for MC4R pathway diseases and advancing additional MC4R programs like bivamelagon and RM-718. Rhythm’s goal is to broaden access to MC4R-targeted therapies for rare patient populations and grow its pipeline toward sustainable commercialization.

Company size: 501-1,000
Company stage: IPO
Headquarters: Boston, MA
Founded: 2008

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