Simplify Logo

Full-Time

Senior – Scientist

Cell Membrane Proteomics

Confirmed live in the last 24 hours

Flagship Pioneering

Flagship Pioneering

501-1,000 employees

Biotechnology firm creating health and sustainability solutions

Healthcare
Biotechnology

Senior, Expert

Boston, MA, USA

This is an on-site role in South Boston.

Category
Computational Biology
Biology Lab & Research
Biology & Biotech
Requirements
  • PhD or equivalent experience in cell biology, spatial biology or proteomics with 3 years additional experience, pharmaceutical experience preferred.
  • Experience developing and implementing screens for comparing antigen expression on cell surfaces and different tissue types.
  • Experience in characterizing epitope accessibility on cell surfaces.
  • Excellent skills with cell culture such as primary cell culture, stable and transient protein expression.
  • Demonstrated ability to conduct original research utilizing cell systems to investigate disease biology or biological therapeutics.
  • Excellent written and verbal communication skills to effectively present results and scientific data to team leaders, cross-functional teams, academic collaborators, or partners.
  • Enthusiastic about playing a pivotal role in the dynamic and multidisciplinary environment of a small biotech, specifically within the realm of in vivo sciences.
Responsibilities
  • Design, plan, and execute transcriptomic or proteomic screen data to select targets of multi-specific antibodies that build on Ampersand’s platform to target specific cells and tissues.
  • Perform spatial analyses of protein or RNA expression patterns.
  • Develop tissue assays to assess binding and drug activity patterns of therapeutic antibodies and multi-specific molecules across portfolio projects, particularly in the fields of inflammation and immunology.
  • Collaborate with our Protein Sciences team to optimize the developability profiles of candidate molecules, and with the In Vivo Pharmacology team to evaluate tissue specific PK/PD, efficacy, and toxicity.
  • Collaborate with and oversee research activities conducted by Contract Research Organizations (CROs).
  • Contribute to preparing and writing INDs for therapeutic candidates.
  • Maintain scientific and technical expertise through familiarity with scientific literature.
  • Contribute to building a positive, team-oriented biotech culture.

Flagship Pioneering fosters a culture of groundbreaking advancements in biotechnology, emphasizing an ecosystem approach that synergizes human health and sustainability. Their business model not only focuses on creating transformative products but also incubates leading companies like Moderna and Indigo Agriculture, positioning them at the forefront of scientific innovation and industry leadership. This approach offers employees a unique opportunity to be part of a pioneering team that drives real-world impacts across multiple sectors.

Company Stage

N/A

Total Funding

$6.4B

Headquarters

Cambridge, Massachusetts

Founded

2000

Simplify Jobs

Simplify's Take

What believers are saying

  • Flagship's recent $3.6 billion raise will support the creation of 25 new breakthrough companies, offering substantial growth opportunities.
  • The firm's track record of founding over 100 biotechnology companies, including industry leaders like Moderna, highlights its potential for high-impact innovation.
  • Key leadership appointments and promotions, such as Lovisa Afzelius to General Partner, strengthen Flagship's strategic direction and operational capabilities.

What critics are saying

  • The ambitious goal of creating 25 breakthrough companies may stretch resources and focus, potentially impacting the quality of each venture.
  • Heavy reliance on AI and advanced computational techniques could face technological and regulatory hurdles, slowing down progress.

What makes Flagship Pioneering unique

  • Flagship Pioneering's focus on creating and developing breakthrough companies in human health, sustainability, and AI sets it apart from traditional venture firms.
  • Their significant capital pool of $10.9 billion and $14 billion in assets under management provides unparalleled financial backing for innovative ventures.
  • Flagship's unique approach to leveraging generative AI for drug discovery and development accelerates the creation of transformative technologies.