Senior Scientist
Protein Engineering and Structural Biochemistry
Updated on 2/12/2024
Alector

201-500 employees

Develops immuno-therapies for neurodegeneration and cancer
Company Overview
Alector stands out in the biotechnology industry with its unique approach of leveraging the body's immune system to combat neurodegeneration and cancer, positioning itself as a leader in immuno-neurology and immuno-oncology. The company's robust portfolio, currently undergoing various stages of clinical trials, is a testament to its commitment to technical advancement and industry leadership. With a culture that encourages bold thinking and a fresh approach, Alector, based in South San Francisco, CA, offers a stimulating work environment for those passionate about making a difference in healthcare.
Biotechnology

Company Stage

Series E

Total Funding

$194.5M

Founded

2013

Headquarters

South San Francisco, California

Growth & Insights
Headcount

6 month growth

-2%

1 year growth

-8%

2 year growth

20%
Locations
San Bruno, CA, USA
Experience Level
Entry
Junior
Mid
Senior
Expert
Desired Skills
Data Analysis
CategoriesNew
Biology & Biotech
Requirements
  • PhD in protein biochemistry, molecular or structural biology with 5+ years, MS with 10+ years, BS with 20+ years of relevant therapeutic discovery experience
  • Strong understanding of biologics therapeutic development and desired candidate profiles
  • Deep knowledge of protein structural biology including protein purification and X-ray crystal structure and/or cryoEM structural determination
  • Strong expertise in biochemistry and protein-protein interaction such as SPR characterization, and structure/function relationships
  • Expertise in molecular biology and protein engineering techniques, including mutagenesis, molecular cloning, construct design, protein expression and purification, protein interaction characterization and DNA sequence analysis
  • Experience with phage and/or yeast display technology
  • Strong organizational skills in data management, timeline management
  • Excellent interpersonal, communication and presentation skills with the ability to coach and mentor more junior scientists, as well as positively influence project direction and strategy
  • Self-motivated, creative problem solver, and value teamwork
Responsibilities
  • Utilize proven knowledge in protein structural biology and biochemistry to support protein designs and optimization workflow
  • Contribute to challenging reagent designs and generation for antibody discovery and engineering
  • Apply computational tools and protein engineering expertise to design and execute antibody humanization, affinity, and developability optimization, as well as protein engineering strategies
  • Serve as program lead and subject-area expert to coordinate data management, data analysis, and presentations, and contribute to cross-functional experimental designs, decision making in a collaborative and timeline-driven manner
  • Help train and mentor junior scientists
Desired Qualifications
  • Experience with phage and/or yeast display technology