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Atrium Therapeutics

Develops RNA drugs for rare genetic heart diseases

Postdoctoral Scientist - In Vitro Cardiac Functional Biology

ContractUpdated
$90k/yr+ 401(k) match
Mid
PhD
San Diego, CA, USA
In PersonOnsite in San Diego, California.
Biology & BiotechTranslational Research & Bench Biology

About the job

Requirements
  • A Ph.D. in cardiac physiology, pharmacology, bioengineering, cell biology, molecular biology, or a related discipline, completed by the position’s start date.
  • Hands-on experience culturing and functionally characterizing cardiomyocytes.
  • Experience developing and executing calcium imaging or contractility assays.
  • Ability to design experiments, troubleshoot assays, analyze quantitative data, and integrate functional findings with molecular endpoints.
  • Strong organizational, collaboration, and scientific communication skills, with the ability to work independently in a fast-paced research environment.
  • Proficiency with computer and data analysis and management skills, including Microsoft Office Suite, Prism, and Electronic Lab Notebook (ELN).
  • Ability to perform standard laboratory activities, with or without reasonable accommodation, including standing, repetitive pipetting, fine-motor work, and use of required personal protective equipment.
  • Ability to occasionally move laboratory supplies or equipment weighing up to 20 pounds.
Responsibilities
  • Design and execute in vitro studies using human iPSC-derived cardiomyocytes, primary adult cardiomyocytes, and engineered cardiac tissues to characterize AOC therapeutic candidates.
  • Develop, optimize, and apply functional assays, including calcium transient imaging and Mantarray-based contractility measurements.
  • Analyze and integrate functional, target-knockdown, and downstream molecular data to characterize pharmacology, investigate mechanism of action, and support candidate selection.
  • Lead a defined research project and collaborate with cross-functional scientists on study design, data interpretation, and program decisions.
  • Communicate research findings through experimental documentation, internal presentations, peer-reviewed publications, and external scientific presentations.
Desired Qualifications
  • Experience with human iPSC-derived cardiomyocytes, primary adult cardiomyocytes, or engineered cardiac tissues.
  • Familiarity with the Mantarray platform.
  • Experience with siRNA or other oligonucleotide therapeutics, genetic cardiomyopathies, or discovery-stage drug development.
  • Scientific publication or conference presentation experience.

About the company

Atrium Therapeutics develops RNA-based therapies for rare, life-threatening genetic heart diseases. It aims to deliver RNA drugs specifically to heart muscles, using a proprietary platform that pairs tissue-targeting monoclonal antibodies with oligonucleotides for precise genetic modulation. Unlike broader biopharma players, Atrium focuses on cardiomyopathies with no approved treatments and operates at the preclinical stage with two main candidates, ATR 1072 (PRKAG2 syndrome) and ATR 1086 (PLN cardiomyopathy), plus undisclosed targets. The company’s goal is to treat the underlying genetic causes of these diseases and bring therapies to patients who currently have no options.

Company Size

51-200

Company Stage

IPO

Headquarters

San Diego, California

Founded

2025

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Benefits

  • Health Insurance
  • Dental Insurance
  • Vision Insurance
  • Disability Insurance
  • Unlimited Paid Time Off
  • Stock Options
  • Company Equity
  • 401(k) Company Match
  • Wellness Program
  • Professional Development Budget

Company News

DirectorsTalk Interviews
Oct 12th, 2026
Atrium Therapeutics, Inc. (RNA): investor outlook reveals 197.62% potential upside.

Atrium Therapeutics, Inc. (RNA): investor outlook reveals 197.62% potential upside. For investors delving into the biotechnology sector, Atrium Therapeutics, Inc. (NASDAQ: RNA) presents a compelling case. Currently priced at $8.40, the company's substantial market potential is underscored by an eye-catching analyst forecast indicating a 197.62% upside, with an average target price set at $25.00. This potential growth makes Atrium a noteworthy candidate for investors seeking high-risk, high-reward opportunities within the healthcare sector. Atrium Therapeutics, based in San Diego, California, is a biopharmaceutical innovator focused on RNA therapeutics targeting cardiomyopathies. Their pipeline includes ATR 1072 and ATR 1086, both siRNA-based therapies aimed at transforming the treatment landscape for genetic and cardiac diseases. This focus on niche yet impactful medical areas could position Atrium as a key player in the biotechnology industry, especially if their partnerships with giants like Bristol-Myers Squibb and Eli Lilly yield successful outcomes. Despite its promising prospects, Atrium's current financial metrics reflect the high-risk nature typical of development-stage biotech firms. The company does not currently generate positive net income, with an EPS of -5.44 and a revenue growth rate of -21.90%. Additionally, valuation metrics such as P/E and Price/Book ratios are not applicable, signaling that traditional valuation methods may not accurately capture the company's potential at this stage. The technical indicators provide a mixed picture. The stock is trading below both its 50-day and 200-day moving averages, at $11.06 and $12.47 respectively, with an RSI of 34.67 suggesting it may be approaching oversold territory. The MACD and Signal Line further indicate a bearish trend, with values at -0.91 and -1.02. These technical signals hint that while the stock may currently be under pressure, it could also present a buying opportunity for those willing to speculate on its future growth. Atrium's lack of dividend yield and payout ratio aligns with the typical biotech model, where reinvestment in R&D takes precedence over immediate shareholder returns. However, the unanimous buy ratings from analysts reflect strong market confidence in the company's long-term potential. Investors should weigh Atrium's promising therapeutic pipeline and strategic partnerships against the inherent risks of investing in a company that is still in the development phase. The potential for significant capital appreciation exists, but it is accompanied by the volatility and uncertainty that come with speculative biotech investments. For those with a higher risk tolerance, Atrium Therapeutics might just offer the kind of upside that makes the risk worthwhile. * Written by: Madison Wilson

Market Chameleon
Oct 8th, 2026
Atrium Therapeutics announces $50 million private placement.

Atrium Therapeutics announces $50 million private placement. PRNewswire 8-Oct-2026 6:31 AM SAN DIEGO, Oct. 8, 2026 /PRNewswire/ - Atrium Therapeutics, Inc. (NASDAQ:RNA) ("Atrium" or the "Company"), a biopharmaceutical company advancing precision cardiology by developing RNA therapeutics targeted to the heart, today announced that it has entered into a securities purchase agreement (the "purchase agreement") with a group of leading institutional investors for a private placement financing (the "private placement"). The private placement is expected to result in aggregate gross proceeds to the Company of approximately $50 million, before deducting placement agent fees and other offering expenses. The private placement includes participation from Sirenia Capital Management LP, Aberdeen Investments, Montanova, Sessa Capital, Casdin Capital, a life sciences-focused institutional investor and others. Pursuant to the terms of the purchase agreement, the Company agreed to issue and sell an aggregate of (i) 5,170,384 shares of its common stock, at a price of $7.93 per share, and (ii) pre-funded warrants to purchase up to 1,134,930 shares of common stock, at a price of $7.929 per pre-funded warrant, which equals the per share price of $7.93 less the exercise price $0.001 for such pre-funded warrant. The pre-funded warrants are immediately exercisable and will expire when exercised in full. The private placement was priced at-the-market under the rules of The Nasdaq Stock Market LLC. The private placement is expected to close on or about October 9, 2026, subject to the satisfaction of customary closing conditions. The Company intends to use the net proceeds from the private placement, together with its current cash, cash equivalents and investments, to fund development of its two lead product candidates, other research programs, working capital and general corporate purposes. The Company estimates that the net proceeds from the private placement together with existing cash, cash equivalents and investments, will fund its operations through 2028.

PR Newswire
Oct 8th, 2026
Atrium Therapeutics raises $50M to advance RNA-based cardiac therapies through 2028

Atrium Therapeutics has secured $50 million in a private placement from institutional investors including Sirenia Capital Management, Aberdeen Investments, Montanova, Sessa Capital, and Casdin Capital. The biopharmaceutical company will issue approximately 5.2 million shares of common stock at $7.93 per share and pre-funded warrants for an additional 1.1 million shares. The San Diego-based firm develops RNA therapeutics targeted to the heart for treating cardiomyopathies. Proceeds will fund development of its two lead product candidates, research programmes, and working capital. The company estimates the funding, combined with existing cash, will support operations through 2028. The private placement is expected to close on 9 October 2026. Leerink Partners served as lead placement agent, with Cantor, Barclays, and Wells Fargo Securities also acting as agents.

DirectorsTalk Interviews
Oct 5th, 2026
Atrium Therapeutics, Inc. (RNA): stock analysis reveals 218.88% potential upside.

Atrium Therapeutics, Inc. (RNA): stock analysis reveals 218.88% potential upside. Atrium Therapeutics, Inc. (RNA) has garnered significant attention from investors, thanks to its robust potential upside of 218.88%. As a key player in the biotechnology sector, the company is pioneering advancements in RNA therapeutics aimed at revolutionizing the treatment of cardiomyopathies. With its headquarters in San Diego, California, Atrium is strategically positioned within the United States' vibrant healthcare landscape. Currently, Atrium's stock is trading at $7.84, with a 52-week range between $7.84 and $16.54. While the stock has experienced a slight decline of 0.30 (-0.04%) recently, the longer-term potential remains promising, especially considering its average target price of $25.00 set by analysts. Such a target highlights the impressive growth prospects that the company's innovative therapies could unlock in the near future. Atrium's focus on siRNA-based therapies, ATR 1072 and ATR 1086, targets genetic conditions like PRKAG2 syndrome and PLN cardiomyopathy. These efforts underscore the company's dedication to addressing unmet medical needs in cardiology, a commitment further emphasized by its strategic partnerships with pharmaceutical giants Bristol-Myers Squibb and Eli Lilly. Despite a challenging revenue growth rate of -21.90%, the investment community remains optimistic, as reflected by the four buy ratings and no hold or sell ratings from analysts. The absence of a trailing P/E ratio and the presence of a negative forward P/E of -0.97 suggest that Atrium is in a high investment phase typical of biopharmaceutical companies, emphasizing future growth over present earnings. The company's technical indicators present a mixed picture. The 50-day and 200-day moving averages are higher than the current price, at $11.40 and $12.61 respectively, indicating a potential undervaluation. Meanwhile, an RSI (14) of 34.67 suggests that the stock is nearing oversold territory, which might appeal to value-oriented investors looking for entry points. The MACD and signal line further indicate bearish momentum, yet such indicators can shift rapidly, especially in a sector as dynamic as biotechnology. Atrium's market cap of $134.11 million places it within the small-cap category, often associated with higher volatility but also significant growth potential. The lack of dividends should not dissuade investors focused on capital appreciation, especially given the high-risk, high-reward nature of investing in biotech startups. For investors considering Atrium Therapeutics, the prospects of its RNA-based therapies present a compelling case. The company is at the forefront of a transformative approach to treating genetic cardiac diseases, and its collaborations with industry leaders bolster its research capabilities and market reach. While the path forward involves navigating inherent industry risks, the potential rewards, as evidenced by the substantial upside, make Atrium a noteworthy consideration for growth-oriented investors. * Written by: Madison Wilson

Yahoo Finance
Sep 6th, 2026
Atrium's (RNA) pipeline advances as Wall Street withdraws amid rising cash burn

Atrium Therapeutics reported second-quarter 2026 results showing clinical progress alongside mounting cash burn. The company received FDA clearance for its IND application for ATR 1072 and launched Corventis, its first Phase 1/2 trial testing a disease-modifying treatment for PRKAG2 syndrome. Atrium earned a $15 million milestone payment from its Bristol Myers Squibb partnership, adding to $3 million in collaboration revenue already booked. With $263.9 million in cash as of 30 June, the company projects funding through mid-2028. Second-quarter expenses totalled $25.6 million, including $15.3 million on research and development. Atrium expects first patient enrollment by end-2026, with initial proof of concept data in second half 2027. An IND filing for ATR 1086 is planned for 2027.