Research Associate II / Senior Research Associate @ BigHat Biosciences

The role: BigHat Biosciences is seeking a self-motivated individual for a Research Associate II / Senior Research Associate to develop label-free assays for characterizing antigen-antibody interactions. You will interface regularly with the Protein Sciences, Discovery, and Translational Research Groups to support all aspects of biophysical characterization of antigen-antibody binding in a fast-paced and multidisciplinary environment.

Develop and perform kinetic experiments to study antigen-antibody interactions
Perform epitope binning and quantitation experiments
Develop and onboard kinetic assays for screening antibodies in a high-throughput manner
Run multi-analyte ELISA/MSD experiments to identify polyreactive antibodies from discovery campaigns
Write and transfer SOPs for used by the production team
Keep a detailed record of all experiments using BigHat’s documentation tools, and clearly communicate results and challenges.
Present experimental plans and results during regular meetings with manager and science teams.

B.S. with 2+/4+ or M.S. with 1+/3+ years of work experience.
Experience using label-free biophysical techniques to study antigen-antibody interactions
Extensive experience in developing and executing BLI experiments for kinetics, quantitation, and epitope binning.
Experience developing SPR assays to study antigen-antibody interactions is preferred.
Good record keeping skills using LIMS and electronic notebooks
Excited to work with diverse, cross functional teams to onboard new assays and disseminate results
Prior experience with MSD or Gyroslab for multiplexed analyte detection and automation are preferred.
Prior experience with multi-color flow cytometry is preferred.

6 month growth

1 year growth

2 year growth