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Ellison Institute of Technology

Interdisciplinary R&D translating science into products

Genotyping and Event Delivery Manager - Plant Biology Institute

Translational Research & Bench BiologyConfirmed live in the last 24 hours
Full-timeOxford, UKIn-person

About the Job

Requirements

  • A PhD in Plant Biotechnology, Molecular Biology, Genetics, Genomics, Crop Science or a related discipline, or an MSc with significant relevant industry experience, and at least 5–7 years of experience in plant biotechnology, genotyping, molecular characterization or event advancement.
  • Demonstrated expertise in genotyping technologies for gene edited and transgenic plants, including PCR, qPCR, ddPCR, KASP, Sanger sequencing, amplicon sequencing and next-generation sequencing-based approaches.
  • Strong experience designing, validating and interpreting molecular assays for event confirmation, including copy number, zygosity, insertion confirmation, junction analysis, backbone screening, edit outcome analysis and segregation tracking.
  • Strong understanding of crop transformation workflows and the practical requirements for moving events from transformation through regeneration, sampling, genotyping, greenhouse transfer and downstream handover.
  • Experience interpreting molecular data for genome editing outcomes, including indels, precise edits, multiplex edits, chimerism or mosaicism and off-target assessment.
  • Experience with electronic lab notebooks, laboratory information management systems, sample barcoding, plate maps, structured data capture, event inventory management and data integrity practices.
  • Project management skills, including milestone tracking, resource planning, vendor management, risk management and stakeholder coordination.
  • Proven ability to manage external vendors, service providers or collaborators for genotyping, sequencing, DNA extraction, assay development or molecular characterization.
  • Ability to communicate event status, molecular data, risks and advancement recommendations clearly to scientific, operational and leadership audiences.
  • Troubleshooting, documentation and continuous improvement capabilities.

Responsibilities

  • Lead the event delivery workflow from transformation output through plant recovery, sampling, molecular confirmation, quality review, advancement decisions and handover to trait, greenhouse or product teams.
  • Design, validate and implement genotyping assays for transgenic and gene edited events, including transgene presence or absence, edit detection, zygosity, copy number, junction assays, backbone absence, on-target and off-target analysis, segregation tracking and event integrity.
  • Apply appropriate genotyping technologies, including endpoint PCR, qPCR, ddPCR, KASP, high-resolution melting, Sanger sequencing, amplicon sequencing, targeted sequencing, next-generation sequencing and targeted capture approaches, to support event selection.
  • Partner with the Vector Design Manager to ensure every construct is paired with a fit-for-purpose molecular assay plan before transformation begins.
  • Develop event stage-gate criteria and decision frameworks for advancing gene edited and transgenic events based on edit outcome, transformation quality, copy number, expression or reporter data, regeneration status and downstream programme needs.
  • Coordinate sample collection, DNA extraction, plate maps, barcoding, chain of custody, sample submission, vendor shipment and data return across internal laboratories and external service providers.
  • Work with bioinformatics and data teams to analyze edit outcomes, chimerism or mosaicism, indel profiles, sequence confirmation, off-target risk, event integrity and molecular quality metrics.
  • Own event inventory management, genotype data capture, sample traceability and event status dashboards using electronic lab notebooks, laboratory information management systems and structured data systems.
  • Track pipeline metrics including event yield, transformation efficiency, edit frequency, assay success rate, quality-control pass rate, sample turnaround time, regeneration-to-confirmed-event conversion and event delivery timelines.
  • Manage external genotyping, sequencing and molecular characterization service providers, ensuring quality, turnaround time, budget and data format expectations are met.
  • Create standard operating procedures, sample submission templates, assay validation standards, quality-control checklists, data interpretation guides and event handover templates.
  • Develop detailed project plans, resource forecasts, risk registers and milestone dashboards for event confirmation and delivery activities.
  • Train and mentor scientists, research associates and technicians in sample tracking, genotyping workflows, assay interpretation and event advancement criteria.
  • Ensure transformation outputs are converted into well-characterized, decision-ready events that can be advanced efficiently and confidently.
  • Support intellectual property creation, regulatory readiness and commercial translation by ensuring event data packages are accurate, traceable and fit for purpose for downstream development.
  • Collaborate with vector design, crop transformation, tissue culture, greenhouse, trait discovery, bioinformatics, automation and artificial intelligence, regulatory and intellectual property, legal, procurement and external partner teams.
  • Present event delivery status, molecular characterization data, genotyping assay performance, risks and mitigation plans to project teams and leadership.
  • Define clear standards for event sampling, molecular quality control, genotyping interpretation, event advancement and handover across the pipeline.
  • Contribute to training and capability building across the Plant Biology Institute, including best practice in genotyping assay development, event confirmation and data integrity.
  • Represent the event delivery and genotyping function in internal and external collaborations, ensuring scientific quality, confidentiality and timely delivery.
  • Establish an event delivery and genotyping capability that improves speed, predictability and confidence in gene edited and transgenic crop event generation.
  • Improve event advancement decisions by ensuring transformation outputs are molecularly confirmed, quality-reviewed and prioritized using clear stage-gate criteria.
  • Reduce wasted downstream effort by filtering events early using robust genotyping, molecular quality control and data-driven decision-making.
  • Support translation of scientific discoveries into commercially applicable crop improvement tools and trait products, including intellectual property and regulatory-ready data packages.

Desired Qualifications

  • Experience in industrial agricultural biotechnology, commercial seed or trait development, molecular breeding, crop transformation platforms or product development pipelines.
  • Hands-on experience with corn, wheat, soybean or other major crop species, including genotype-dependent transformation and event recovery challenges.
  • Experience developing regulatory-ready molecular event data packages or working within Good Laboratory Practice, quality management system or quality-controlled research environments.
  • Experience with high-throughput genotyping workflows, 96- or 384-well sample handling, automation, liquid handling, laboratory information management system integration and dashboard reporting.
  • Experience with whole-genome sequencing, targeted capture, off-target prediction or validation, or bioinformatics-supported edit analysis.
  • Experience building or leading a small technical team and establishing new operational processes in a fast-moving research environment.

About the Company

Ellison Institute of Technology

Interdisciplinary R&D translating science into products

The Ellison Institute of Technology unites science, engineering, policy, and entrepreneurship to tackle big global problems through four focus areas: Health, Medical Science & Generative Biology; Food Security & Sustainable Agriculture; Clean Energy Generation & Storage; and Artificial Intelligence & Robotics. It translates scientific discovery into commercial products and sustainable companies, reinvesting profits to fund more research; a key project is the GPAS bioinformatics platform for rapid pathogen analysis to help prevent pandemics. The institute differentiates itself through a deep alliance with the University of Oxford, an alliance faculty model that allows researchers to work across both institutions, and patient capital commitments to fund high-risk, high-reward research. Its goal is to solve global challenges by turning scientific breakthroughs into market-ready solutions and sustainable enterprises.

Company size
201-500
Company stage
Not listed
Total funding
Not listed
Headquarters
Oxford, United Kingdom
Founded
2023

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