Research Scientist - Multiple Teams

Mayo Clinic Arizona is pioneering the future of cardiovascular care through transformational research in cardiac regeneration and translational cardiovascular science. Our Department of Cardiovascular Medicine seeks an exceptional research scientist to establish a cutting-edge program addressing fundamental challenges in cardiovascular disease through innovative approaches in regenerative medicine, cardio-oncology, or related translational research areas.

This position directly supports Mayo Clinic's transformational vision to shift healthcare from reactive treatment to predictive prevention, aligning with:

Genesis Initiative: Revolutionizing transplant discovery and developing alternatives to cadaveric transplant through pioneering science in cellular engineering, advanced cell therapy products, and bioartificial organ systems.

Precure Initiative: Developing platform products that enable prediction and prevention of diseases through biological signatures, real-time sensing technologies, and algorithmic approaches.

Bold. Forward. Transformation: Accelerating the path from discovery to clinical treatment, leveraging AI and data intelligence to reimagine clinical trials and therapeutic development.

Our department has established significant research infrastructure in cardiac regeneration, with active programs focusing on cell-based therapy for ischemic heart disease, enhancement of hiPSC-derived cardiomyocyte regenerative potency, neonatal heart regeneration and molecular pathways regulating cardiomyocyte proliferation, and nanoparticle-based, cell-type specific drug delivery systems. Our diverse extramural and intramural funding portfolio, inclusive of four active NIH R01 grants totaling over $8 million, demonstrates significant investigator excellence and national competitiveness.

We seek an innovative investigator who will establish a complementary and symbiotic research program in cardiac regeneration, cardio-oncology, or related translational cardiovascular science areas that align with our department's strategic vision and existing research infrastructure.

Preferred Expertise

Candidates should demonstrate technical excellence and a proven track record in cardiovascular research. We welcome applications from investigators in diverse but complementary research areas including:

Essential Qualifications:

• MD, MD/PhD, or PhD in cardiovascular science, cell biology, developmental biology, bioengineering, oncology, or related field
• Strong publication record in peer-reviewed journals with first or senior author publications in high-impact journals
• Record of competitive extramural funding (NIH R01 or equivalent federal/foundation support) or clear trajectory toward independent funding
• Experience with advanced research methodologies relevant to cardiovascular disease

Areas of Particular Interest:

• Cardiac regeneration and tissue engineering
• Cardiac valves regeneration and bioengineering
• Cardiac electrophysiology and regenerative medicine
• Cardio-oncology and cardiovascular complications of cancer therapies
• Stem cell biology and cellular reprogramming
• Gene therapy and genetic modification approaches
• Cardiovascular immunology and inflammation
• Bioengineering and biomaterials for cardiac applications

Additional Preferred Qualifications:

• Experience with in-vivo models (small or large animal)
• Proficiency in advanced molecular techniques (single-cell sequencing, CRISPR, optogenetics, etc.)
• Collaborative research experience with clinical and/or translational programs
• Track record in translational research with potential for clinical application
• Experience with drug delivery systems or therapeutic development

Ideal Candidate Profile

• Active research program supported by NIH or equivalent funding
• Physician-scientists with substantial research portfolios are strongly encouraged to apply
• Demonstrated commitment to team science and fostering an inclusive research environment
• Proven ability to bridge basic science discovery with clinical translation

The successful candidate will join the Department of Cardiovascular Medicine and contribute to enterprise-wide research and translational activities. Mayo Clinic Arizona is part of a three-site integrated academic medical center with expectations to integrate locally and collaborate broadly across the enterprise. The research program will be based at Mayo Clinic Arizona (Scottsdale or Phoenix campus).

Department of Cardiovascular Medicine at Mayo Clinic Arizona

The Department of Cardiovascular Medicine at Mayo Clinic Arizona is one of the most dynamic and rapidly growing cardiovascular programs in the United States, encompassing six specialized divisions (Cardiac Electrophysiology, Interventional and Structural Heart, Cardiovascular Imaging, Advanced Heart Failure and Transplant, Cardiac Subspecialties, and Comprehensive and Preventive Cardiology), with over 80 providers serving more than 40,000 patient visits annually. Our heart transplant program ranks among the best in the nation, with the shortest median wait time to transplant in Arizona  and a 3-year patient survival rate of 92.2%, 9th highest in the U.S. We perform the full spectrum of advanced cardiovascular procedures, from pulsed field ablation and complex coronary interventions to TAVR, transcatheter valve repair, and ventricular assist device implantation, supported by a state-of-the-art Cardiovascular Artificial Intelligence Core Team that is redefining early detection and personalized treatment.

Research is a cornerstone of our departmental identity. In 2025, our faculty produced 184 peer-reviewed publications, with 79% of staff authoring at least one article,  and supported 39 active grants and 73 research professionals. Our cardiac regeneration program alone holds four active NIH R01 grants totaling over $8 million, and new research scientist hires will benefit from a rich collaborative infrastructure that includes shared core facilities, an integrated electronic health record, and direct access to Mayo Clinic’s enterprise-wide biorepositories and translational science platforms. The successful candidate will join a department that couples world-class clinical volume with a deeply committed research culture, creating an unparalleled environment to develop and sustain an independent, nationally competitive research program.

Highlights of Mayo Clinic Research Enterprise

• Over 5,000 research personnel, including 321 faculty level research investigators and 948 physicians who are actively involved in research
• 11,220 peer-reviewed papers were published in 2024
• Investments in research each year result in hundreds of new clinical trials. In 2024, the institution received over $753 million in extramural research awards supplemented with over $517 million of institutional support
• Nearly 10,000 active studies involving human participants in progress. More than 5,900 research grants and contracts
• State-of-the-art laboratories and shared resource facilities, including those for microscopy and imaging, cell and molecular biology, animal models, production of iPS cells and clinical grade MSCs, biomedical engineering and mathematics, materials testing, a Medical Genomics Facility, a Mouse Modeling Facility, Molecular and Microscopic Core Facilities, and unique Human Disease Tissue Banks
• Over 420,000 square feet of research laboratory space includes several robotic freezers capable of storing 3.5 million DNA samples
• Mayo Clinic supports innovation and has a wealth of resources available – including an integrated health record and collaboration with top specialists

About Mayo Clinic

Mayo Clinic is top ranked in more specialties than any other care provider according to U.S. News & World Report. With a 73,000-person workforce, Mayo Clinic cares for more than 1.3 million people each year with serious or complex illnesses from all 50 U.S. states and 130 countries. Mayo Clinic is the largest not-for-profit, multidisciplinary academic medical center in the world with over 4,000 physicians and scientists in an integrated multi-campus system spanning the globe.

The unified mission at Mayo Clinic is to provide the best patient care, backed by our expertise and supported by innovation in education, research and practice, to bring hope and healing in times of need. We embrace collegial relationships among campuses (Arizona, Florida and Minnesota) allowing for best practices and innovation to help solve the most serious complex medical challenges, one patient at a time.

Mayo Clinic Arizona is making significant investments in both the physical and technological future of health care, through doubling the size of the Mayo Clinic campus in Phoenix, inclusive of practice, education, and research activities. Mayo Clinic's campuses in Arizona are in Phoenix and Scottsdale, in the beautiful Sonoran Desert. The region is known as the Valley of the Sun, a metropolitan area with more than 4 million residents in 25 cities and towns.

As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in a highly competitive compensation package with substantial long-term institutional and departmental support for salary, personnel, equipment, and travel as well as a competitive startup package all designed to ensure immediate and continued success. Additional benefits for faculty at Mayo Clinic include intramural funding opportunities for research and innovation. We provide an outstanding, comprehensive benefits package that includes plenty of options for medical, dental and vision care; flexible spending accounts; life insurance; short- and long-term disability coverage; travel allowance; generous time away; and more! We are proud to be among the few U.S. companies to provide a pension benefit at no cost to employees plus you can add the Mayo 403(b) plan which features an employer match.