Vice President - Biometrics

The role:

Dispatch is seeking a Vice President, Biometrics to establish and lead our Biometrics function as we enter the clinic. Reporting to our Chief Medical Officer, you will be one of the first members of our Development team, joining shortly after the start of our first clinical study. This is a builder’s role: our biometrics strategy, standards, processes and vendor model are still taking shape, and you will define how biostatistics, statistical programming and clinical data management are done at Dispatch — while rolling up your sleeves to do much of the work yourself. You will not inherit a large team but rather we are looking for a hands-on leader who is energized by building something from the ground up and scaling it thoughtfully as our pipeline grows.

You will be the statistical voice of our development strategy, ensuring scientific rigor in how we design studies, select doses, interpret emerging data and make program decisions. Your closest partners will be the VP Regulatory Affairs, VP Clinical Operations and VP Clinical Development, and you will work as a core member of cross-functional program teams alongside the Head of Program and Portfolio Management and our Product Team Leads, as well as colleagues in Translational Science, Research and Technical Operations. Externally, you will select and oversee CROs, functional service providers, data management vendors and statistical consultants, and support interactions with regulators, independent safety and data monitoring committees, investigators, investors and partners.

Key responsibilities:

• Build the biometrics function from the ground up, including the strategy, operating model (in-house versus outsourced), SOPs, data standards (e.g., CDISC SDTM/ADaM), templates and analysis infrastructure — right-sized to our stage and designed to scale
• Serve as the hands-on lead statistician for our ongoing first-in-human study: author and review statistical sections of protocols, statistical analysis plans, TLF specifications and data review plans, and perform or QC key analyses
• Provide statistical leadership on early-phase design, including dose-escalation and dose-expansion strategies, model-based and Bayesian dose-finding methods, two-stage and single-arm designs with efficacy/futility boundaries, and dose optimization consistent with current FDA and global health authority expectations
• Drive timely, rigorous interpretation of emerging safety and efficacy data (e.g., ORR, duration of response, PFS, OS) to inform safety review committees, interim analyses and program go/no-go decisions
• Partner with Clinical Development and Program and Portfolio Management on clinical development plans and target product profiles, contributing sample size, probability-of-success and scenario analyses to evaluate potential paths to registration
• Partner closely with the VP Regulatory Affairs to lead the statistical content of regulatory interactions and submissions, including briefing documents, IND amendments, annual reports/DSURs, end-of-phase meetings and expedited program requests, and plan ahead for integrated analyses and BLA readiness
• Oversee clinical data management in partnership with Clinical Operations, including EDC build, data quality and cleaning strategies, data review and database lock, ensuring data integrity and inspection readiness
• Select, contract and manage CROs and biometrics vendors, holding them accountable for quality, timelines and budget
• Collaborate with Translational Science to integrate biomarker, pharmacokinetic/cellular kinetic and exploratory data into analyses that deepen our understanding of mechanism and patient response
• Evaluate and apply innovative methods where they add value, such as artificial intelligence and machine learning applications, external control and real-world data approaches to contextualize single-arm results
• Ensure the accuracy and appropriate statistical framing of external data communications, including congress abstracts, presentations and publications, as well as data shared with potential partners and investors
• Scale the function as we evolve toward a multi-program, multi-region clinical portfolio, hiring thoughtfully and developing team members as the needs of the business grow

Required experience & skills:

• Ph.D. in Statistics, Biostatistics or a related quantitative field; candidates with a Master's degree will also be considered
• At least 15 years of experience in clinical development statistics within the biopharmaceutical industry, with progressive leadership responsibility, including leading a biostatistics or biometrics function or serving as the lead statistician across multiple programs
• Substantial hands-on oncology experience, including design and analysis of early-phase oncology studies and familiarity with oncology endpoints and response criteria (e.g., RECIST, time-to-event endpoints)
• Demonstrated expertise in innovative early-phase designs, including dose-escalation and dose-expansion approaches
• Direct experience leading statistical contributions to FDA interactions and regulatory submissions (e.g., IND, end-of-phase meetings); contribution to at least one BLA/NDA/MAA
• Strong working knowledge of ICH guidelines (including E9/E9(R1)), GCP, CDISC standards and relevant FDA guidance
• Proven track record of selecting and overseeing CROs and functional service providers in an outsourced operating model
• Hands-on proficiency in SAS and/or R, and willingness to personally perform and QC analyses
• Comfort operating as a leader with a small team (but with no team at first) and a strong desire to build
• Collaborative nature, geared toward cross-functional teamwork; able to influence peers and leaders without relying on hierarchy
• Excellent organizational, problem-solving and time management skills, with the judgment to manage competing priorities
• Positive attitude, dedicated work ethic and flexible orientation for operating in a fast-paced, entrepreneurial environment where processes are still being built
• Strong verbal and written communication skills, including the ability to translate complex technical concepts for clinical, scientific, executive and external audiences
• Comfortable giving and inviting candid feedback, and flagging risks early, before key decisions are made

Preferred experience & skills:

• Experience with cell therapy (e.g., CAR T) or gene therapy programs, including analysis of cellular kinetics and immune-related safety events such as CRS and ICANS
• Experience in oncology, especially solid tumors and particularly gastrointestinal cancers
• Experience supporting expedited regulatory pathways, including Breakthrough Therapy designation and accelerated approval based on single-arm studies
• Experience with Bayesian methods, external control arms or real-world evidence in a regulatory context
• Prior experience as the first or founding biometrics leader at an early-stage biotech
• Experience supporting ex-US clinical studies
• Experience supporting business development diligence, financing or IPO-related data activities

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Base Salary Range: $280-355K