BiomeSense

At-home biosensor with AI microbiome analytics

Senior Mechanical Engineer

Design EngineeringConfirmed live in the last 24 hours

Full-timeChicago, IL, USAIn-person

About the Job

Requirements

A bachelor's degree in Engineering or a related field and at least five years of hardware development experience.
Experience independently designing complex, novel hardware and test fixtures using computer-aided design (CAD).
Ability and willingness to perform precise, hands-on assembly and testing of complex electromechanical hardware.
Experience with prototyping techniques such as 3D printing and light machining.
Ability to perform detailed wiring, harnessing, and soldering.
Ability to work in an organized, proactive, and independent manner, own ambiguous work through resolution, and collaborate across disciplines.
Experience with instrument control software and scripting; ability to interpret test results and translate findings into design improvements.

Responsibilities

Own key technical workstreams responsible for the success of next-generation GutLab hardware while providing hands-on support.
Devise solutions to complex mechanical design problems, balancing performance, risk, and timelines.
Integrate mechanical, electrical, and fluidic systems into robust products and resolve system-level tradeoffs.
Perform detailed electrical, mechanical, and fluidic assembly of prototypes and subassemblies; lead hands-on validation of new designs.
Diagnose and repair complex hardware, software, and firmware issues in the lab and field; identify root causes and drive fixes.
Design and improve test setups, fixtures, and automation to optimize assembly and validate hardware; maintain a clean, organized, inventoried hardware lab.
Create clear standard operating procedures, manuals, test records, and design documentation for repeatable production; flag risks and assembly feedback early.

Desired Qualifications

Experience taking a new product from prototype to production.
Expertise in Design for Assembly (DFA) and Design for Manufacturing.

Senior Mechanical Engineer
Compensation: $100k – $150k salary + 0.1%– 0.25% equity + benefits
Full benefits, including health coverage, PTO & parental leave

About BiomeSense
BiomeSense is a life sciences startup applying gut microbiome technologies (GutLab, MetaBiome) to advance personalized medicine. We partner with UCSF, UCSD, NIH & the University of Chicago & are backed by LabCorp Ventures, Bluestein Ventures, Seerave Foundation & Emil Capital Partners.
Key Responsibilities
You will own key technical workstreams responsible for the success of our next-generation GutLab hardware, while providing hands-on support.

Mechanical Design of Novel Hardware: Devise elegant solutions to complex mechanical design problems, balancing performance, risk, and timelines

Systems Integration: Integrate mechanical, electrical, and fluidic systems into robust products; resolve system-level tradeoffs

Hardware Build & Test: Perform detailed electrical, mechanical, and fluidic assembly of prototypes and sub-assemblies; lead hands-on validation of new designs

Troubleshooting & Repair: Diagnose and repair complex hardware, software, and firmware issues in lab and field; identify root causes and drive fixes

Testing & Automation: Design and improve test setups, fixtures, and automation to optimize assembly and validate hardware; maintain a clean, organized, inventoried hardware lab

Documentation & Quality: Create clear SOPs, manuals, test records, and design documentation for repeatable production; flag risks and assembly feedback early

Qualifications

Bachelor’s Degree in Engineering or related field and 5+ years in hardware development

Experience independently designing complex, novel hardware and test fixtures using CAD

Proven ability and willingness to perform precise, hands-on assembly and testing of complex electromechanical hardware

Experience with prototyping techniques (e.g., 3D printing, light machining)

Proven ability to perform detailed wiring, harnessing, and soldering

Highly organized, proactive, and independent; owns ambiguous work through resolution and collaborates across disciplines

Experience with instrument control software and scripting; able to interpret test results and translate findings into design improvements

Preferred Qualifications:

Experience taking a new product from prototype to production
Expertise in Design for Assembly (DFA) and Design for Manufacturing

Hiring Process Note: We are a small team and we review all resumes, screening questions and assessment scores manually. However this focus on manual review limits our ability to respond to direct messages through LinkedIn and other channels. We appreciate your effort in applying and we thank you for your understanding.

About the Company

BiomeSense

At-home biosensor with AI microbiome analytics

BiomeSense offers a platform for gut microbiome analysis that combines an at-home biosensor for continuous monitoring with a cloud-based AI-powered analytics system. It enables longitudinal, low-cost data collection for clinical trials and consumer health, moving beyond single-time-point samples. The biosensor gathers microbiome-related data at home and transmits it to the cloud, where AI analyzes trends to generate insights. It differentiates itself by providing an integrated hardware-software solution for large-scale data collection, helping researchers and product developers accelerate precision medicine.

Company size: 11-50
Company stage: Seed
Total funding: $5.4M
Headquarters: Chicago, IL
Founded: 2018

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