A PhD, MD, or master's degree and at least five years of experience in biomedical research, drug discovery, or a similar field are required.
Proven experience in venture creation or operational roles at early-stage venture-backed startups is required.
Technical expertise in antibody and/or oligonucleotide drug discovery and development is required.
Experience supporting therapeutic assets through discovery, preclinical, and/or clinical development in a scientific or operational role is required.
Ability to work across various United States and international time zones is required.
Ability to accommodate occasional travel, approximately 20%, is required.
Responsibilities
Create capital-efficient biotechnology companies with strong investible scientific narratives through the venture studio model, using access to drug discovery platforms, research and development experts, validating experiments, lead discovery and optimization, target prioritization, fundraising strategy, and capital access.
Contribute as a co-founder by handling operational and scientific details and optimizing operations so management team members and scientists can focus on their strengths and drive company value.
Operate in the chief executive officer or chief operating officer role for new companies and be accountable for company building, including investor syndication, entity incorporation, strategic and operating plans, product roadmaps from concept to clinic, TCPs and TPPs, budgets and forecasts, key opinion leader relationships and scientific advisory boards, work plans with research and development teams, and scientific operations.
Negotiate with potential venture capital and pharmaceutical partners and service providers to establish fair and equitable relationships, including negotiating term sheets.
Lead portfolio companies toward equity financing and high-value transactions with pharmaceutical and biotechnology partners.
Build antibody-oligonucleotide conjugate-based companies using ex-hepatic delivery shuttles and the AntiClastic oligonucleotide platform, collaborating with external co-founders to turn therapeutic ideas into differentiated assets in neurology, rare disease, and other indications.
Desired Qualifications
Prior experience in a senior or C-suite role is highly desirable.
Prior experience with antibody-oligonucleotide conjugates or ex-hepatic delivery is highly desirable.
Strong business acumen and the ability to manage complex transactions are desirable.
Role Location: Waltham, MA
The Company We are Alloy Therapeutics — a biotechnology ecosystem and Product Development Organization (PDO) empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100% of our revenue in innovation and access to innovation. May the Best Drug Win.
Alloy has evolved from a startup into a global product development organization operating 11 divisions across 5 research sites in 4 countries on 3 continents. Our model - Integrated Independence - combines centralized capabilities with entrepreneurial operating divisions. Successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.
At Alloy, we have an ethos of "Mentorship-By-Apprenticeship" in all of our positions. We strive to have workers in the office when needed to interact organically and face-to-face. Of course, as a lab-based operation, our cells and animals grow 7 days a week, 365 days per year. We respect and value our colleagues for their hard work that requires them to be in the lab every day. We ask our people who have more flexible accommodations to appreciate their colleagues who have less flexibility. We are all one team!
About the Role In 2020, Alloy launched its venture studio 82VS, which works with talented academics, entrepreneurs, biotech companies, and venture capitalists to build and support early stage, asset focused startups leveraging the tools and capabilities of the Alloy ecosystem. To date 82VS has founded or supported 20 asset-focused companies developing new medicines across the areas of oncology, immunology, ophthalmology, neurology, nephrology, and rare diseases. These companies are advancing antibody, multispecific, oligonucleotide, and TCR mimic based therapeutics, with an expanding focus on developing multimodal platforms including delivery shuttles and antibody-oligo conjugate (AOCs).
As a Venture Partner at 82VS, you will be provided with agency to work and collaborate across scientific, operational, and business areas to build new biotech companies from idea to Series A and/or high-value M&A, whichever comes first. You will bring your “no task too small mentality” to all of your work and will manage everything from the smallest operational and scientific details to the largest strategic and business elements. You will work daily with Founders, drug discovery scientists, KOLs, VCs, and biopharma collaborators to build ideas into capital-efficient companies with investible asset-centric portfolios. This role requires a philosophical belief that out collaborating is better than out competing in the development of medicine. This role will report to the President of 82VS with autonomy owning various stakeholders, projects, and initiatives in a dynamic start-up environment.
This Venture Partner role will focus on the development of next-generation antibody-oligo conjugate based companies leveraging Alloy’s expanding suite of ex-hepatic delivery shuttles and proprietary AntiClastic oligonucleotide platform. You will work across multiple NewCo builds in collaboration with external co-founders to translate therapeutic ideas into differentiated assets in neurology, rare disease, and other indications.
This is a 2 year role with the expectation that you will transition into a leadership role at one of the companies that you form during that time.
How You’ll Drive Impact
Establish: create the most capital-efficient biotech companies with strong investible scientific narratives in a venture studio model. The model provides support including access to Alloy drug discovery platforms and R&D experts, early validating experimentation, lead discovery, lead optimization, target prioritization, fundraising strategy and access to capital. This enables our entrepreneurs to achieve financial independence in 18-24 months. You will be the Co-Founder that contributes irreplaceable value by picking up all of the loose ends of a company and optimizing operations for success to allow management team members, and scientists to shine with their strengths and drive value for the company.
Operate: step into the CEO/COO seat for your new companies and be accountable for all aspects of the build including syndicating with other investors, incorporating new entities, developing and implementing strategic and operating plans including product roadmaps from concept to clinic, TCPs and TPPs, building budgets and forecasts, establishing strong KOL relationships and SAB, developing work plans with Alloy’s R&D teams and managing scientific operations.
Negotiate: broker with potential partners (e.g., VC and pharma) and service providers to ensure fair and equitable relationships with our partners; strong fences build strong neighbors, which start with term sheets and share the common goal of making medicine together.
Transact: lead portfolio companies to equity financing and high value transactions with pharmaceutical/biotech partners to accelerate the discovery and development of the programs and medicines that we build. Success for a Venture Partner is seeing each of their companies achieve a Series A financing led by a world-class venture capital firm or M&A by a leading biopharma company, in order to accelerate the development of medicines and their access to patients.
Required Qualifications
PhD, MD, or Masters with 5+ years experience in the fields of biomedical research, drug discovery or similar.
Proven experience in venture creation or operational roles at early-stage venture backed start-ups. Prior experience in a Senior or C-suite role is highly desirable.
Technical expertise in antibody and/or oligonucleotide drug discovery and development. Prior experience with antibody-oligo conjugates or ex-hepatic delivery is highly desirable
Experience supporting the advancement of therapeutic assets through discovery, pre-clinical, and/or clinical development in a scientific or operational role
Exceptional leadership, strategic planning, and decision-making skills. Strong business acumen and ability to manage complex transactions is desirable.
Ability to work across various US and international time zones.
Accommodate occasional travel as needed (20%).
Taking Care of Our People We support the individuality of what people need to do outside of work to empower them to do their best at work. While you focus on making better medicine together, we focus on programs and benefits that support a diverse and growing team. Whether you’re single, in a growing family, or nearing retirement, Alloy offers a variety of comprehensive and competitive benefits starting from day one.
Compensation
Competitive base and equity compensation commensurate with level of experience and independence
401(k) company match
Health & Family
Generous personal and family medical, dental and vision benefits with 100% of premiums and deductibles covered
Company-paid disability (STD, LTD) and life insurance
Paid parental leave
Family planning support up to $45,000 (e.g., IVF/PGT, adoption, surrogacy, egg retrieval)
Unique Perks
Unlimited PTO (paid time off) and flexible schedules
Annual stipend for continuing education with commitment to your career through individualized professional development plan
Wellness and Extensive Employee Assistance Program (EAP) including resources for mental wellness
Pay Transparency At Alloy Therapeutics, we believe in fostering trust and open communication. For this role, the estimated range is $265,000-$325,000, with the final offer based on factors like your experience, skills, and alignment with our needs.
Additionally, this role is eligible for equity compensation, reflecting our commitment to shared success as we work together to make better medicines.
We are proud to offer competitive compensation and benefits, aiming to support our team’s professional and personal well-being. If you have any questions about pay or benefits, we’re here to help.
Alloy Therapeutics is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, national origin, sex, sexual orientation, gender identity, veteran status, disability, or other legally protected status. If you are unable to submit an application because of incompatible assistive technology or a disability, please contact us at [email protected]. We will make every effort to respond to your request for disability assistance as soon as possible.