Director of Metabolic and Inflammatory Diseases

Company Summary:

Metaphore Biotechnologies, Inc. is a privately held biotechnology company building the next generation of biological therapeutics. Inspired by nature, our mission is to transform patient lives by unlocking the power of biological therapeutics with a new mimic-discovery platform.

Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

Position Summary

Metaphore Bio is actively seeking a talented and highly motivated Director of Metabolic and Inflammatory Diseases to join Translational Sciences team at our lab in Cambridge, MA. The successful candidate will be instrumental in defining and developing therapeutics leveraging Metaphore’s platform as well as leading programs from early discovery through late preclinical development. The role requires significant experience in the metabolic/obesity and inflammatory disease areas and a strong preference for experience in GPCR biology. A strong preference for those with experience in the discovery and development of biologics. Demonstrated success as a project leadership and strong people leadership skills are also required. 

Responsibilities

• Lead and build Metabolic and inflammatory focused research group at Metaphore Biotechnologies, setting the strategy and vision for the function in the context of the platform

• Support the advancement of therapeutic candidates from discovery to late preclinical development 

• Play active role in shaping the metabolic/obesity and inflammatory disease portfolio at Metaphore, understanding platform capabilities and clinical unmet need to identify and pursue the development of novel therapeutics 

• Project leadership of development programs, cross-functionally leading team of computational scientists, protein engineers and translational scientists to effectively and efficiently develop therapeutics candidates 

• Set and manage budget for the group, including managing in-house and external resources to achieve program specific goals in timely and budget conscious manner 

• Build and lead a team of scientists, supporting their scientific and personal development 

Qualifications

• PhD or MS in metabolic, biochemistry, immunology or related field

• Minimum 8+ years of experience in industry, leading and representing the metabolic disease function on project teams

• A proven track record of displaying excellent interpersonal and communication skills both written and oral and ability to communicate complex information succinctly.

• Extensive industry experience in the discovery and development of large molecule/biologics therapeutics in the context of metabolic disorders

• Project leadership experience, preferably in context of biologics and/or the development of therapeutics that leverage ML/AI

• Experience managing PhD and non-PhD scientists 

• Expertise in the biology of GPCRs, preferably in the context of biologics but relevant experience in development of small molecule therapeutics targeting GPCRs is sufficient

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.