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Exthymic

Point-of-care autologous cell therapy manufacturing platform

Integration Engineer

Biomedical Engineering & Medical DevicesPosted on Nov 12
Full-timeSan Diego, CA, USAIn-person

About the Job

Requirements

  • A bachelor's degree in mechanical, electrical, biomedical, or mechatronics engineering, or a related field, or equivalent hands-on experience.
  • At least 3 years of experience in instrument assembly, integration, test, or manufacturing engineering, preferably on electromechanical or laboratory instruments.
  • Hands-on mechanical assembly from drawings, wiring and cable harnessing, fluidic tubing and fittings, and safe use of hand and power tools.
  • Ability to troubleshoot mechanical, electrical, fluidic, and software faults using multimeters, oscilloscopes, pressure and flow sensors, and data acquisition systems.
  • Experience writing and executing test protocols and documenting builds and tests so others can reproduce them.
  • Ability to read CAD models, such as Onshape, or similar, and electrical schematics.
  • Experience analyzing test data and drawing conclusions from it.
  • Willingness to work with biological systems and learn aseptic technique.

Responsibilities

  • Assemble and integrate prototype instruments, subassemblies, and test rigs, including mechanical assembly, fluidic plumbing, cable harnesses, and sensor and actuator hookup.
  • Bring up new builds with design engineers, document deviations and fixes, and report assembly issues back to design.
  • Work with design engineers and scientists to turn requirements into test plans and protocols with clear acceptance criteria, sample sizes, and measurement methods.
  • Plan subsystem and integrated-instrument test campaigns around upcoming design decisions.
  • Run bench and integration tests on prototypes, subsystems, and full instruments, covering flow and volume accuracy, pressure, leak integrity, and thermal, optical, motion, and electrical performance.
  • Support cell-based runs with scientists, and build and maintain the fixtures and test harnesses needed for testing.
  • Write test reports supporting design verification and maintain traceability from requirements to test results.
  • Characterize failures, file reproducible issue reports, and support root cause investigation and retesting.
  • Maintain prototype instruments and test equipment, including preventive maintenance, calibration, cleaning, spare parts, and records of each unit's hardware and software revision.
  • Diagnose and repair faults, and help automate data capture and instrument health checks.
  • Follow assembly instructions and standard operating procedures while building and testing, report unclear, incorrect, or missing content, and work with the authors on revisions.
  • Train and mentor junior engineers and technicians on assembly, test execution, and documentation.

Desired Qualifications

  • Experience integrating and testing fluidic, optical, thermal, or motion control systems.
  • Experience maintaining and calibrating lab or production equipment, or supporting equipment qualification (IQ/OQ/PQ).
  • Test automation or data acquisition scripting using Python, LabVIEW, or similar.
  • Experience with embedded controllers, sensors, and motor drivers.
  • Exposure to design controls, ISO 13485, or GMP documentation practices.
  • Mammalian cell culture or biology lab experience.
  • Early-stage startup experience.

About the Company

Exthymic

Point-of-care autologous cell therapy manufacturing platform

Exthymic develops a point‑of‑care manufacturing platform to democratize autologous cell therapies by moving production from centralized facilities to near the patient, at or around treatment centers. The platform aims to streamline the logistics-heavy process of taking a patient’s cells, manufacturing a personalized therapy (such as CAR‑T) locally, and delivering it back, thereby cutting turnaround times and costs. The team draws on founder Rich Stoner’s background in biomanufacturing, genome engineering, and big‑space biotech startups, focusing on a decentralized approach to cell therapy bioprocessing. While details are sparse, the company has a patent tied to microfluidic devices for high‑throughput single‑cell analysis, suggesting a direction toward compact, scalable manufacturing tools. Exthymic aims to broaden patient access to personalized therapies by reducing logistics hurdles and bringing production closer to where patients are treated.

Company size
Not listed
Company stage
Grant
Total funding
$35.2M
Headquarters
San Diego, CA
Founded
2023

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