Crescent Biopharma

Clinical-stage biotech developing solid-tumor therapies

Vice President

Biology & BiotechConfirmed live in the last 24 hours

Full-timeWaltham, MA, USA

About the Job

Requirements

Experience leading cross-functional teams in Phase 1–3 drug development is required, and oncology experience is required.
An advanced degree in Medical or Life Science, an MD, PhD, or MBA, or equivalent is required.
A minimum of 12 years of pharmaceutical-industry experience in leadership positions in drug development with a proven track record driving programs through IND, early clinical, pivotal stages, and approval; alternatively, at least 12 years in significant development and/or commercial leadership or general management positions, including work with development teams in a cross-functional setting, is required.
A track record of delivering business objectives and activities or milestones leading to filing and launching, and strong knowledge of oncology, are required.
The candidate should be an entrepreneurial team leader able to shape and communicate the vision for a therapeutic program and guide the development and execution of product strategy.
Demonstrated experience building effective and motivated cross-functional teams and guiding teams and organizations through complex, high-stakes, data-driven decisions is required.
The candidate must be able to pace team work toward milestones in a highly competitive landscape.
Strong verbal, written, and presentation communication skills, including the ability to communicate complex ideas clearly to stakeholders and teams at all levels, are required.

Responsibilities

Lead a high-performing cross-functional Program Team, focusing on strategy, priorities, output, resources, and building a fulfilling, collaborative, and sustainable team environment.
Establish a robust, well-understood Program strategy for bringing a medicine to patients in need.
Ensure research, non-clinical, clinical, regulatory, CMC, and commercial strategies and plans align with the overall Program strategy.
Structure and facilitate critical cross-functional decisions within the Program Team and senior leadership team, considering relevant perspectives and driving efficient decisions.
Own Program recommendations across stages to achieve milestones and timelines.
Drive preparation and presentation of materials for the Board of Directors.
Communicate proactively with senior leadership and stakeholders about Program strategy, status, priorities, risks, and needs, and facilitate appropriate decision-making.
Monitor emerging developments, external non-clinical and clinical data updates, and competitive intelligence in oncology, and ensure learnings and implications are communicated and reflected in internal Program plans.
Build a visible, constructive, and credible presence within relevant disease-area key opinion leader and patient communities.
Participate in business development activities as needed, including opportunity evaluations and due diligence.
Foster collaboration, innovation, discovery, scientific excellence, open communication, and continual improvement in R&D.
Coach team members to achieve their best and support them in mitigating skill or capacity gaps.
Consider Program needs in the context of corporate strategy and priorities, and advocate for the Program among senior leadership.
Lead in accordance with Crescent’s core values.

Desired Qualifications

Experience with antibody-drug conjugates (ADCs) is a plus.

Salary Range: 323000 to 357000 (Currency: USD) (Pay period: per-year-salary)

Crescent Biopharma’s vision is to build a world leading oncology company bringing the next wave of therapies for cancer patients. The Company’s clinical-stage pipeline includes its lead program, a PD-1 x VEGF bispecific antibody, as well as novel antibody-drug conjugates. By leveraging multiple modalities and established targets, Crescent aims to rapidly advance potentially transformative therapies as single agents and as part of combination regimens to treat a range of solid tumors. For more information, visit www.crescentbiopharma.com and follow the Company on LinkedIn and X.

We are seeking a Program Team Leader (PTL) is a passionate drug developer with a global perspective and business orientation, who brings adaptable leadership, strategic product development acumen, and relentless pursuit of long-term success for patients and Crescent’s medicines. This is a highly visible leadership role. Working with an experienced Program Manager and a cross-functional team, the PTL shapes the Program strategy, goals, priorities, and plans, bringing both a 'future-orientation' toward the ultimate goal of broad, global commercial access for patients in need, and a "pragmatic-orientation" to chart the path, mitigate risks, cultivate options, and lead through complex drug development decisions. This role is based in Waltham, MA and you must have experience in the oncology space.

Responsibilities

Lead a high-performing cross-functional Program Team, focusing on both the "what", such as strategy, priorities, output, and resources, and also the "how", such as building a fulfilling, collaborative, and sustainable team environment
Establish a robust and well-understood Program strategy for bringing a life-changing medicine to patients in need
Ensure that research, non-clinical, clinical, regulatory, CMC, and commercial strategies and plans are aligned with the overall Program strategy
Structure and facilitate critical cross-functional decisions within Program Team and senior leadership team, bringing all relevant perspectives to bear while driving to efficient decisions in a fast-paced environment
Own Program recommendations across stages of the Program to achieve milestones and timelines
Drive preparation and presentation of materials for Board of Directors
Maintain clear, open, and proactive communication with the senior leadership team and other stakeholders regarding Program strategy, status, priorities, risks and needs, and facilitate appropriate decision-making
Keep abreast of emerging developments, external non-clinical and clinical data updates and competitive intelligence in oncology ensure learnings and implications to Crescent programs are communicated and reflected in internal program plans
Build visible, constructive, and credible presence within KOL and patient community for relevant disease areas
Participate in business development activities, as needed, including opportunity evaluations and due diligence
Foster a culture of collaboration, innovation, discovery, and cutting-edge R&D focused on scientific excellence, open communication, and continual improvement
Actively coach team members to achieve their best and support to mitigate gaps in skill or capacity
Consider needs of the Program in context of Crescent corporate strategy and priorities, as primary advocate for the Program among Crescent senior leadership
Lead with Crescent’s core values at the forefront

Education & Experience

Experience leading cross-functional teams in Phase 1-3 drug development is required; oncology experience is required and experience with ADCs a plus
Advanced degree in Medical or Life Science, MD, PhD or MBA or equivalent
A minimum of 12 years of experience in pharmaceutical industry in leadership positions in drug development and proven track record in driving Programs through IND, early clinical, pivotal stages and approval or at least 12 years in pharmaceutical industry in significant development and/or commercial leadership or general management positions including working with development teams in cross-functional setting
Exceptional track record of delivering on business objectives, activity/milestones leading to filing and launching, and strong knowledge of oncology
Entrepreneurial team leader, able to shape and communicate the vision for an important therapeutic program and guide the development of the product strategy and its execution
Player/coach with demonstrated experience in building highly effective and motivated cross-functional teams and in guiding teams and organizations in making complex and high-stakes data-driven decisions
Outstanding sense of urgency and ability to pace the team's work to achieve milestone achievement in highly competitive landscape
Excellent communication skills (verbal, written, presentation) and ability to clearly communicate complex ideas to stakeholders and teams at all levels

What We Offer

Opportunity to join a mission-driven team where you'll contribute to impactful work, take on varied responsibilities, and grow quickly in a dynamic environment
Competitive compensation, including base salary, performance bonus, and equity
100% employer-paid benefits package
Flexible PTO; also, two, one-week company-wide shutdowns each year
A commitment to your professional development, with access to resources, mentorship, and growth opportunities

Crescent Biopharma is an Equal Opportunity Employer. We are committed to fostering a diverse, inclusive, and equitable workplace where all individuals are valued and respected. Employment decisions are based on qualifications, merit, and business needs, without regard to race, color, religion, gender, sexual orientation, national origin, disability, veteran status, or any other protected status.

About the Company

Crescent Biopharma

Clinical-stage biotech developing solid-tumor therapies

Crescent Biopharma develops oncology therapies for solid tumors, led by CR-001, a tetravalent bispecific antibody that blocks PD-1 and VEGF to boost anti-tumor immunity while inhibiting tumor blood vessel growth. CR-001 sits in a global Phase 1/2 ASCEND trial, and the pipeline also includes CR-002, an anti-PD-L1 antibody-drug conjugate, and CR-003, an ITGB6-targeted ADC. The company differentiates itself by combining immune checkpoint blockade with VEGF inhibition and other targeted modalities to build an immuno-oncology backbone for solid tumors, supported by strategic partnerships and substantial private placements. Crescent’s goal is to advance multi-agent regimens toward regulatory approval and commercial development for patients with solid tumors.

Company size: 51-200
Company stage: IPO
Headquarters: Waltham, MA
Founded: 2003

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