Generation Bio is innovating non-viral genetic medicines to provide durable and redosable treatments for hundreds of millions of patients living with rare and prevalent diseases. The company is developing two distinct and complementary platforms: a potent, highly selective cell-targeted lipid nanoparticle (ctLNP) delivery system and a novel immune-quiet DNA (iqDNA) cargo produced by a scalable capsid-free manufacturing process that uses proprietary cell-free rapid enzymatic synthesis (RES). With these platforms, Generation Bio aims to develop the next wave of non-viral genetic medicines to support its mission to extend the reach of genetic medicine to more people living with more diseases, around the world.

We are a thriving, collaborative, creative community of 110 people with diverse talents, beliefs, and experiences headquartered in Cambridge, Massachusetts.

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SUMMARY:

Generation Bio is seeking an energetic and highly motivated molecular biologist with broad mechanistic understanding of mammalian cellular trafficking to join our team. The Principal Scientist hired will focus on development of platform technologies to enhance nuclear translocation and its integration with iqDNA. The successful candidate will bring experience-based insights from scientific fields such as nuclear pore complex structure/ function, cellular trafficking of diverse cargos, mechanism of mRNA export, viral packaging and nuclear translocation. The Principal Scientist will conceive and implement novel approaches to address key platform development goals, developing and driving execution of technical plans individually and as part of teams. This position reports to the VP, head of Molecular Biology and will be responsible for building functional expertise and leading cross functional teams.

RESPONSIBILITIES:

Lead design approaches for optimizing nuclear translocation of nucleic acid cargoes.
Generate appropriately scoped research plans to meet scientific and resourcing demands.
Lead execution of research individually and as part of function and cross functional teams.
Present scientific ideas and results effectively to different teams and groups within the organization.
Accountable for on-time execution of experimental projects to advance our iqDNA platform.

QUALIFICATIONS:

PhD in Molecular Biology, Cell Biology, Synthetic biology, Bioengineering, Biochemistry or related discipline.
Minimum of 6 years of relevant experience, majority in an industry setting.
Experience in scientific fields ofas nuclear pore complex structure/ function, cellular trafficking of diverse cargos, mechanism of mRNA export, viral packaging and nuclear translocation, or related field.
Capacity for innovative thinking and critical problem solving.
Excellent communication and interpersonal skills with capacity and proven track record of working cross functionally.

POSITION: Full-Time, Exempt

EEOC Statement: Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race (to include traits historically associated with race including, but not limited to, hair texture, hair type, hair length, and protective hairstyles such as braids, locks, twists, hair coverings, and Bantu knots), color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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