The Role: BigHat Biosciences is seeking a self-motivated individual for a Senior Research Associate or Associate Scientist* to contribute to and support research on multiple therapeutic antibody engineering/optimization projects.

*At BigHat we believe in titles that are commensurate with skill set, relative organizational impact, and value contribution; more experienced candidates are encouraged to apply, with the understanding that responsibilities and title would adjust as appropriate.

Plan and execute experiments to discover antibodies or to optimize antibody expression, purity, stability, developability, binding affinity, and/or functional activity.
Contribute to the development and optimization of new assays to be run in high-throughput, using automated liquid handlers.
Create SOPs for new or modified assays that demonstrate superior antibody function and transfer SOPs to the Production team as appropriate
Follow laboratory protocols and keep a detailed record of all experiments using BigHat’s documentation tools.
Communicate progress and challenges regularly to ensure efficient progress towards Program goals.
Analyze & summarize results and critical problems in writing and in presentation to a collaborative, cross-functional team.

About you:

MS or PhD in the biological sciences or engineering; familiarity with protein biochemistry/biophysics or protein engineering; strongly self-motivated individual with attention to detail; driven, team-oriented, and excited to work in a dynamic startup environment.

Nice to haves:

MS or PhD in biochemistry, bioengineering, structural biology, or related field
Hands-on knowledge of protein expression and purification
Experience with mammalian cell culture
Experience with ELISA/immunoassay, BLI/SPR, other protein biochemical/biophysical characterization, and/or cell-based assays
Exposure to protein engineering and high-throughput screening
Familiarity with (or interest in) operating automated liquid handlers
Ability to process, analyze, and visualize data in R/Python (or similar)

6 month growth

1 year growth

2 year growth