Senior – Research Associate

Company Summary:

FL106 Inc., is a privately held, early-stage biotechnology company developing a groundbreaking genetic medicine technology platform. Our platform integrates experimental and computational approaches to unlock generative design of novel technologies for a wide range of high unmet-need diseases. FL106 is backed by Flagship Pioneering, bringing the vision and resources to guide FL106 from platform validation to real-world solutions that meaningfully improve patient care.

Position Summary:

FL106 is seeking a highly motivated (Senior) Research Associate with expertise in Cell and Molecular Biology to play a vital role in the company’s efforts to validate novel target discovery approaches. The candidate must be independent, goal oriented, have excellent communication skills and be willing to work in a highly dynamic and fast-paced entrepreneurial environment. This is a unique opportunity to drive the growth of an early-stage biotechnology company where you can contribute to the next frontier of genetic medicines. We are looking for collaborative, enthusiastic problem-solvers to join our team, driven by a shared goal of making a practical impact.

Core Responsibilities:

• Generate and maintain mammalian cell culture lines and perform downstream experiments using novel platform-generated compounds.
• Perform high-throughput nucleic acid and/or protein isolation from cell and animal tissues using  standard and automated systems (e.g. Kingfisher, Qiacube, etc).
• Develop and validate downstream assays (e.g. qRT-PCR, flow cytometry, ELISA) for key readouts of platform-generated compounds.
• Collaborate with team to develop experimental plans, document results in an ELN, and make presentations to report findings to team.
• Work as a key contributor on cross-functional teams including chemistry and in vivo pharmacology.

Qualifications and Skills:

• Bachelor’s degree in Biology or a related field, with 1+ years of laboratory experience preferably in bio-pharmaceutical industry.
• Strong experience with nucleic acid  (DNA/RNA) isolation from mammalian cells and tissues, cDNA synthesis, and qRT-PCR is essential.
• Hands-on experience in mammalian cell culture and using various delivery technologies (e.g. transfection, nucleofection, etc). Experience with human/mouse PBMCs is preferred but not required).
• Experience with developing assays using various readout technologies including qRT-PCR, ELISA, and flow cytometry.
• Candidates of various experience levels will be considered. Position to be determined commensurate with experience.
• Experience with various ELN and LIMS systems.
• Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner, document results in laboratory notebooks.

This role requires a proactive and collaborative individual who is motivated about biological discovery and assay development.

Additional Qualifications (preferred but not required):

• Animal (mouse/rat) handling, take-down, and tissue collection
• In vivo procedures: IV, RO, IP injections

About Flagship

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in generation of over 500 patents, initiation of over 50 clinical trials for novel therapeutic agents and an aggregate value of more than $90 billion. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.