Full-Time

Associate Scientist

Protein Sciences

Updated on 6/13/2024

Flagship Pioneering

Flagship Pioneering

501-1,000 employees

Biotechnology firm creating health and sustainability solutions

Venture Capital

Senior

Cambridge, MA, USA

Requirements
  • Bachelor’s degree in protein biochemistry, chemical engineering, or analytical chemistry with 6+ years industry experience, or Masters degree with 3+ years, post-graduate experience.
  • High-level proficiency in protein purification using FPLC AKTA systems, accompanied by successful and sophisticated analysis.
  • Strong and demonstrable experience in transient transfection of mammalian cells, together with both stable pool generation and advanced cell line development.
  • Experience working in a high-throughput environment managing numerous samples and utilizing barcoding systems.
  • Proficiency in working with enzymatic assays and preparing proteins and complexes for structural studies.
  • Experience with antibody discovery workflows and validation.
  • Proven capability in accurately executing repeated tasks with enthusiasm and precision, especially in roles involving detailed data management.
  • Demonstrated creative thinking abilities, underscored by a significant drive towards innovation and original problem-solving.
Responsibilities
  • Execute protein purifications from small to large scale using gravity purification and multi-mode chromatographic methods on FPLC systems.
  • Establish and execute automated procedures for high-volume purifications utilizing the AKTA system, based on multiple chromatographic technologies including Protein A, IEX, Ni-NTA, and more.
  • Carry out transient and stable transfections using a variety of mammalian cell lines, including but not limited to Expi293 and ExpiCHO. Develop, optimize and implement new technologies and methodologies to improve cell line development and process optimization for robust protein production of challenging proteins.
  • Utilize molecular biology tools to design and verify protein engineering constructs.
  • Use of biophysical tools for protein interaction characterization (Biolayer Interferometry (BLI), Surface Plasmon Resonance (SPR) etc.

Flagship Pioneering fosters a culture of groundbreaking advancements in biotechnology, emphasizing an ecosystem approach that synergizes human health and sustainability. Their business model not only focuses on creating transformative products but also incubates leading companies like Moderna and Indigo Agriculture, positioning them at the forefront of scientific innovation and industry leadership. This approach offers employees a unique opportunity to be part of a pioneering team that drives real-world impacts across multiple sectors.

Company Stage

N/A

Total Funding

$6.4B

Headquarters

Cambridge, Massachusetts

Founded

2000

Growth & Insights
Headcount

6 month growth

10%

1 year growth

19%

2 year growth

45%