Company Summary:

Founded by Flagship Pioneering in 2021, Metaphore aims to unlock breakthroughs that outperform today’s drugs for maximum patient impact, We adapted this idea to drug discovery. MIMIC™, our computationally driven bioplatform that couples machine learning with molecular mimicry, engineers therapeutics to trigger a desired biological response. Our MIMIC platform opens the possibility to develop engineered medicines with specific features to access a range of targets, including those that were previously intractable. Flagship and Metaphore have also just announced a $600M research collaboration with Novo Nordisk to develop up to two next-generation therapeutics for obesity management.

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

Position Summary

We are seeking a talented Associate Scientist/Scientist, specializing in Protein Characterization and Production. The individual will be responsible for the expression, purification and analytical characterization of proteins as part of our collaborative team in support of discovery and AI/ML design efforts. The ideal candidate will be a dedicated and hardworking individual, comfortable with routine tasks, but also equipped with an innovative mindset to add new dimensions to our processes. This is a critical role to help establish best practices and support scale up of Metaphore’s wet-lab workflows and automation build. The right applicants will leverage their expertise in FPLC and various chromatography techniques to ensure reliable delivery of high-quality protein products for varied research applications.

Responsibilities:

• Execute protein purifications from small to large scale using gravity purification and multi-mode chromatographic methods on FPLC systems.
• Establish and execute automated procedures for high-volume purifications utilizing the AKTA system, based on multiple chromatographic technologies including Protein A, IEX, Ni-NTA, and more.
• Carry out transient and stable transfections using a variety of mammalian cell lines, including but not limited to Expi293 and ExpiCHO. Develop, optimize and implement new technologies and methodologies to improve cell line development and process optimization for robust protein production of challenging proteins.
• Utilize molecular biology tools to design and verify protein engineering constructs.
• Use of biophysical tools for protein interaction characterization (Biolayer Interferometry (BLI), Surface Plasmon Resonance (SPR) etc.).

Qualifications:

• Bachelor’s degree in protein biochemistry, chemical engineering, or analytical chemistry with 6+ years industry experience, or Masters degree with 3+ years, post-graduate experience.
• High-level proficiency in protein purification using FPLC AKTA systems, accompanied by successful and sophisticated analysis, is a critical requirement.
• Strong and demonstrable experience in transient transfection of mammalian cells, together with both stable pool generation and advanced cell line development, is important.
• Experience working in a high-throughput environment managing numerous samples and utilizing barcoding systems.
• Proficiency in working with enzymatic assays and preparing proteins and complexes for structural studies.
• Experience with antibody discovery workflows and validation.
• Proven capability in accurately executing repeated tasks with enthusiasm and precision, especially in roles involving detailed data management.
• Demonstrated creative thinking abilities, underscored by a significant drive towards innovation and original problem-solving.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.