Senior Scientist @ Vor Bio

We engineer stem cell transplants that shield healthy cells from targeted therapies

Targeted therapies work by attacking cells that express particular proteins on their surface. Unfortunately, both diseased and healthy cells often express the same proteins, resulting in collateral damage to healthy cells.

At Vor Bio, we engineer hematopoietic stem cells (HSCs) to lack a biologically redundant target protein, then transplant these cells into the patient.

These eHSCs give rise to generations of new healthy blood cells that are effectively shielded from targeted therapies so that only the remaining cancer cells are killed. We are also developing our own CAR-T cell therapy using T cells from the same healthy donor who could potentially provide HSCs for our shielded stem cell transplant and thereby, avoid issues of donor-mismatch. We believe our CAR-T cell therapy may enable more potent and durable responses post-transplant.

Vor Bio is aiming to cure blood cancers through our novel platform combining HSC biology, genome engineering, and targeted therapies to unlock treatment options previously unavailable to patients. Come be a part of a passionate team striving to collaboratively develop a groundbreaking approach to cancer treatment, one of medicine’s greatest challenges.

What we value in our fellow Voracians

Passion: Enthusiastically driving our science toward innovative medicines

Fellowship: Fostering genuine bonds of collaboration and mentorship

Humility: Acting selflessly by putting the collective mission first

Who we are looking for:

Vor Bio is seeking a talented and motivated Senior Scientist to join our Analytical Development team. The successful candidate must possess extensive scientific knowledge and hands-on experience in cell biology/immunology and/or gene-editing. Experience managing direct reports and with HSPCs and/or CAR-T drug products is required. The successful candidate has previous experience in building and optimizing analytical assays to characterize and assess the function of cell therapy products and processes. The candidate will collaborate with the preclinical research team exploring novel technologies and with Process Development, Quality Control and CMC group to develop novel cell therapy platforms. The candidate needs to demonstrate the ability to independently plan, design and execute complicated experiments, and collaborate and communicate, and deliver scientific results effectively within a cross-functional team environment.

Key areas of responsibility:

Independently plan, design, execute, analyze and troubleshoot experiments to improve the understanding of HSPC and CAR-T cell therapy products
Manage direct reports and collaborative efforts within the Process and Analytical Development group
Establish, optimize, and execute in vitro cell-based assays, including cytotoxic assays, CFU, and multi-color flow cytometry
Draft and review SOPs, reports, and assist in the preparation of CMC regulatory submissions
Plan and deliver results according to project timelines
Work collaboratively and communicates data within internal cross-function teams and external CRO; present scientific results at internal and external meetings/conferences

Qualifications:

Ph.D. in cell biology/immunology or related scientific discipline with 5+ years relevant industry/academic experience; or MS with 10+ years’ experience; or BS with 12+ years’ experience
Experience managing direct reports is required
Extensive hands-on experience in HSPC and/or CAR-T cell therapy products is required
Extensive hands-on experience with cell line and primary cell culture is required
Experience in phenotypic and functional characterization of hematopoietic cells and immune cells using multi-color flow cytometry and other functional assays (proliferation, CFU, transplantation) is strongly preferred
Experience developing analytical assays in late-stage clinical development is strongly preferred
Excellent oral and written communication skills and demonstrated ability in presenting scientific results is strongly preferred
Strong problem-solving skills and proven ability to work both independently and in a team in a startup environment is desired
High attention to detail and demonstrated track record of consistently meeting deadlines in a dynamic, fast-paced environment
Experience in cell therapy process, product development and GMP manufacturing is a plus

By becoming a team member here at Vor, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you’ll benefit from discretionary time off, parental leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. We are conveniently located in Cambridge with easy access to public transportation and ample parking.

As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation, inclusiveness, and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race, age, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

Please visit our website at https://www.vorbio.com/ for more information.

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