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Bicycle Therapeutics

Clinical-stage biopharma developing Bicycle Drug Conjugates

Enterprise Architect

IT OperationsConfirmed live in the last 24 hours
Full-timeCambridge, UKNo salary listed

About the Job

Requirements

  • Strong capability across enterprise architecture, solution architecture, cloud, infrastructure, integration, security, and data domains.
  • Understanding of how data warehouse or lakehouse capabilities, integration patterns, data models, governance, and semantic layers enable trusted reporting, analytics, artificial intelligence, and business decision-making.
  • Ability to connect architecture choices to Development, Manufacturing, and G&A processes so technology and data improve operational visibility, control, and decision-making.
  • Ability to lead and develop technical specialists across architecture, cloud, AI Ops, and network/infrastructure engineering, balancing strategic direction, delivery ownership, and practical execution.
  • Practical understanding of security, compliance, GxP, validation, privacy, quality, and data integrity considerations in technology and data architecture.
  • Ability to communicate complex technical choices clearly and influence business, technology, and executive stakeholders.
  • Proven experience designing, evolving, and delivering enterprise architecture across applications, data, cloud, infrastructure, integration, and security.
  • Experience designing and delivering data architecture foundations for data warehouse or lakehouse capabilities, data integration, modelling, governance, and AI-ready data products that support Development, Manufacturing, and G&A processes and decision-making.
  • Experience designing and delivering technology or data solutions in GxP-regulated environments, with a practical understanding of compliance, validation, quality, and data integrity expectations.
  • Practical experience with cloud platforms, solution architecture, infrastructure, integration, and modern platform engineering approaches.
  • Experience leading, coaching, or influencing technical teams across architecture, cloud, AI operations, infrastructure, or data, with evidence of translating strategy into delivered technical outcomes.
  • Ability to engage widely across the organisation and explain complex technical concepts simply to support decisions and transformation.
  • A degree or equivalent practical experience in Computer Science, Information Systems, Engineering, Data Engineering, Bioinformatics, or a related field.

Responsibilities

  • Define, evolve, and deliver the enterprise architecture roadmap across applications, data, cloud, infrastructure, integration, and security, ensuring current and future systems connect effectively and support business growth.
  • Design and deliver how existing and future platforms integrate across Development, Manufacturing, and G&A, reducing fragmentation and enabling secure, scalable, and reusable technology patterns.
  • Shape the architecture for trusted data flow, integration, modelling, and enterprise data warehouse or lakehouse capabilities that support Development, Manufacturing, and G&A business processes, reporting, insight, and decision-making.
  • Ensure architecture and data foundations enable analytics, automation, and AI-ready data products while meeting security, privacy, compliance, quality, and data integrity expectations.
  • Lead and develop the architecture, cloud, AI Ops, and infrastructure engineering capability within IT, setting clear technical direction and helping the organisation make confident, scalable technology choices.
  • Partner with business teams to turn architecture choices into practical roadmaps, standards, and delivered solutions that improve resilience, reuse, simplicity, and speed of change.
  • Lead, coach, and mentor the team, investing in its professional growth and fostering a culture of high performance and psychological safety.
  • Set clear goals and strategic priorities for the team, ensuring its work is aligned with departmental and organisational objectives.
  • Champion company values and embed a culture of collaboration, accountability, and innovation within the team.

Desired Qualifications

  • Architecture or data architecture qualifications, such as TOGAF, cloud architecture, data architecture, data management, or analytics certifications.
  • Experience in pharmaceutical or biotech environments, particularly where technology and data support clinical, manufacturing, quality, regulatory, or corporate functions.

About the Company

Bicycle Therapeutics

Clinical-stage biopharma developing Bicycle Drug Conjugates

Bicycle Therapeutics develops cancer medicines using its Bicycles platform, which uses synthetic two-loop peptides to bind targets with high precision. It creates Bicycle Drug Conjugates that attach a therapeutic payload to the constrained peptide so the drug concentrates in tumor cells, sparing healthy tissue. The company, focused on solid tumors, runs multiple oncology programs in clinical trials and collaborates with major pharma as part of its development strategy. Its goal is to discover, develop, and commercialize targeted cancer therapies through its Bicycle Drug Conjugate pipeline.

Company size
201-500
Company stage
IPO
Headquarters
Cambridge, United Kingdom
Founded
2009

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