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Monte Rosa Therapeutics

Develops targeted protein degraders for therapy

AI Lead: Agentic Systems - Biotech R&D

AI Application EngineeringConfirmed live in the last 24 hours
Full-timeBasel, SwitzerlandCHF140k - CHF175kIn-person

About the Job

Requirements

  • A PhD in machine learning, computer science, statistics, bioinformatics, physics, engineering, or another quantitative discipline is required; computational biology training is not required.
  • Substantial experience as an applied machine learning scientist or machine learning engineer, with a record of original technical thinking and strong execution.
  • A proven track record building and deploying large language model-based or agentic systems in real workflows; prototype-only or prompt-engineering experience is insufficient.
  • Deep knowledge of agent architectures, including planning, tool calling, retrieval-augmented generation, structured outputs, memory and context management, multi-agent coordination, and human-in-the-loop design.
  • Strong Python and production engineering skills, including APIs, testing, containers, cloud deployment, and observability.
  • Experience building artificial intelligence data infrastructure such as pipelines, ontologies, knowledge graphs, and semantic search.
  • Depth in at least one scientific data domain, such as omics, clinical, chemistry, imaging, or biomedical text.
  • Ability to evaluate artificial intelligence systems scientifically using benchmarks, error analysis, provenance, and monitoring, and to work with scientists to drive adoption.

Responsibilities

  • Own the vision, architecture, and roadmap for agentic artificial intelligence across discovery, translational science, clinical development, and commercialization.
  • Identify high-value scientific workflows and redesign them around artificial intelligence agents from first principles rather than incremental automation.
  • Build the data and knowledge layers agents need by integrating omics, clinical, chemistry, assay, literature, patent, and regulatory data.
  • Develop connectors, APIs, semantic and metadata layers, and vector, hybrid, and knowledge-graph retrieval systems so agents can reliably use internal and external data and tools.
  • Deploy secure, auditable agentic systems with human-in-the-loop oversight, tracing, permissioning, and monitoring.
  • Establish evaluation frameworks covering task benchmarks, factuality and provenance checks, failure-mode analysis, reproducibility, latency, and cost tracking.
  • Partner directly with scientists to turn research needs into products and move from prototype to adopted workflow.
  • Drive adoption of agentic-first ways of working through demonstrations, embedded partnerships, training, and reusable patterns.
  • Track advances in foundation models, multimodal models, and agent architectures, and turn them into practical internal capabilities.
  • Define outcome-based success measures, including cycle-time reduction, decision quality, adoption, and reuse.
  • Mentor and grow the artificial intelligence team as the organization scales.

About the Company

Monte Rosa Therapeutics

Develops targeted protein degraders for therapy

Monte Rosa Therapeutics develops molecular glue degraders (MGDs) to treat cancer and autoimmune/inflammatory diseases using its QuEEN discovery engine, a platform that fuses AI-guided chemistry, proteomics, and structural biology to design MGDs. MGDs work by bringing a target protein together with an E3 ligase, tagging the protein for destruction by the cell's proteasome rather than just inhibiting it. The company distinguishes itself with the QuEEN platform, partnerships with Roche and Novartis for joint development and funding, and a portfolio that includes MRT-2359, MRT-6160, and MRT-8102 as clinical-stage programs. Its goal is to discover, develop, and commercialize MGDs, grow its pipeline, and create value through collaborations, upfront payments, milestones, and royalties while delivering treatments for patients with serious diseases.

Company size
201-500
Company stage
IPO
Headquarters
Boston, MA
Founded
2018

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