Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

We are looking for a highly motivated individual with experience in portfolio management and decision analysis and a passion for developing solutions for complex problems to build out this cross-functional capability and help shape our portfolio strategy. This is an exciting opportunity to build out and lead the Portfolio Management function at Revolution Medicines. This position will report to the VP, Program, Portfolio and Alliance Management (PPAM) and will be based at our headquarters in Redwood City, CA.

As the Head of Portfolio Management, you will be responsible for the Portfolio Management function, facilitating the Portfolio Working Group (PWG), and evolving the wider portfolio management capability within Revolution Medicines. This is a highly cross-functional role, working closely with the PWG (currently chaired by our President, R&D), Program Teams, Analytics and Insights, Finance, and many other relevant functions. You will be an active member of the PPAM LT, collaborating closely to develop talent, share learnings, cultivate and implement best practices, and ensure consistent ways of working across PPAM and the broader organization.

The Head of Portfolio Management must be entrepreneurial, able to “roll up their sleeves” and thrive in a fast-paced, highly cross-functional environment. You are an exceptional strategic and critical thinker, have a passion for interpreting and analyzing complex data, and have strong interpersonal skills that you will leverage to successfully partner cross-functionally with internal teams and senior stakeholders.  

• Develop and implement a vision for Revolution Medicine’s Portfolio Management function.

• Lead the build out of the portfolio management capability, partnering with R&D Leadership, Commercial, Finance, Program Management and other functions – including

  • Identify current and future needs and evolve capabilities to remain fit for purpose as our portfolio continues to increase in complexity.

  • Implement best practices including development and use of qualitative and quantitative methods for portfolio prioritization, decision analysis, project trade-offs, and assigning probability of success to support decision making.

  • Develop portfolio dashboards and reports supporting executive decision making.

• Facilitate and project manage the Portfolio Working Group (PWG) – including

  • Partner with the PWG Chair to define appropriate strategic context for the portfolio and program decisions and execution.

  • Plan and prioritize agenda topics by business criticality ensuring effective and timely discussion and resolution, in partnership with the PWG Chair and Program Team Leads.

  • Prepare stakeholders and presenters and assist in developing appropriate materials.

• Drive the development and collation of R&D inputs for program and portfolio evaluations, including target product profiles, development plans and probability of success assessment, and ensure consistency with financial and commercial inputs.

• Closely partner with Program Teams and relevant functions on the application of analytical tools and frameworks to clearly present options and solutions to optimize the portfolio and help them navigate through the relevant decision-making bodies.

• Maintain a detailed understanding of the shape and drivers of the portfolio through pro-active involvement with key stakeholders and assess impact of external developments on our portfolio.

• Lead and manage other high impact projects that arise outside of regular portfolio planning cycles, ensuring that these one-off initiatives are aligned to overall business objectives.

• Contribute to the overall strategy and development of PPAM, as a member of the PPAM LT.

• Uphold an open, inclusive and collaborative culture with a focus on shared learning and people development.

Required Skills, Experience and Education:

• 10+ years’ experience in the biotech/pharmaceutical industry with 5+ years’ experience in portfolio management, portfolio planning or similar function(s).

• Experience with clinical development stages and understanding of the external landscape and key players in the Oncology space.

• Strong insight into strategic and commercial drivers of the pharmaceutical market with a thorough understanding of the drug development and commercialization process.

• Experience building out (sub)functions and implementing infrastructure and best practice.

• Exceptional analytical and problem-solving skills, with the ability to interpret complex data, and present it in a clear and concise manner.

• Proficiency in utilizing data to drive strategic decision making and portfolio optimization.

• Proven ability to think strategically with sound judgment and decision-making.

• Demonstrated leadership, influencing skills, critical thinking, creativity, and ability to manage complexity and operate amidst ambiguity.

• Excellent interpersonal skills and the ability to build and maintain positive work relationships to effectively interface at all levels across the organization.

• Demonstrated ability to lead cross-functional teams and drive results in a dynamic and fast-paced environment.

Preferred Skills:

• B.A. or BSc. in Life Sciences with an MSc, MBA or Ph.D.

• Line management experience preferred, matrix management experience acceptable alternative.

The base salary range for this full-time position is $253,000 to $305,000 for candidates based at our headquarters in Redwood City, CA. The range displayed on each job posting is intended to be the minimum and maximum salary for the position in Redwood City and will be adjusted for the local market a candidate is based. Our salary ranges are determined by role, level, and location. Individual pay is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact [email protected].

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