Full-Time

Architect – Information Security/Data Privacy

Posted on 3/26/2026

St. Jude Children's Research Hospital

St. Jude Children's Research Hospital

10,001+ employees

Pediatric cancer treatment and research nonprofit

No salary listed

Memphis, TN, USA

In Person

Bachelor's

Category
IT & Security (1)
Required Skills
MLOps
Microsoft Azure
Machine Learning
AWS
DevOps

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Requirements
  • Bachelor’s degree in computer science, information assurance, MIS or related field, or equivalent. Certification Requirements: an expert level security certification (e.g., CISSP, CISM, OSCP, CASP, etc.)
  • 10+ years in cybersecurity including risk, compliance, and security engineering.
  • Strong experience architecting enterprise security and privacy solutions across datacenters and public, private, and hybrid cloud environments (AWS or Azure preferred).
  • Proven background (5+ years preferred) in enterprise technology design, implementation, and delivery.
  • Deep expertise in cloud computing—SaaS, PaaS, IaaS—and modern cloud security architectures.
  • Mastery of cybersecurity controls including SIEM, IDS/IPS, IAM, PKI, EDR, threat intelligence platforms, and security automation/orchestration.
  • Solid understanding of risk and compliance frameworks such as NIST, ISO 27001, PCI DSS, and privacy regulations.
  • Experience designing secure AI/ML systems and mapping controls to risk and regulatory frameworks.
  • Ability to translate cybersecurity and privacy risks for technical and non-technical executives.
  • Experience architecting SIEM, threat intelligence platforms, SOAR, IDS/IPS, FIM, DLP, and enterprise monitoring tools.
  • Demonstrated ability to lead, mentor, influence, and communicate clearly across diverse engineering and business teams.
Responsibilities
  • Stay ahead of emerging security threats; assess enterprise systems and data to ensure robust defense.
  • Evaluate cutting-edge and disruptive cybersecurity technologies and influence leadership on adoption strategies.
  • Design, validate, and guide deployment of secure solutions that balance data protection, risk, and business value.
  • Lead security and privacy architecture across public, private, and hybrid cloud environments (AWS/Azure).
  • Architect secure business-to-business integrations, third-party solutions, vendor ecosystems, and outsourced services.
  • Own the full-lifecycle security architecture for AI/ML systems, including: Secure data ingestion, Controlled model development, training & deployment, MLOps/DevSecOps integrations, Model integrity, privacy risk assessments & secure inference.
  • Build automated controls that reduce model poisoning, data exfiltration, and AI misuse.
  • Ensure compliance with evolving data privacy and AI regulations.
  • Partner with legal, risk, and compliance teams to ensure adherence to regulatory and ethical requirements (privacy laws, AI regulations, internal risk frameworks).
  • Develop and maintain security and data privacy standards, policies, procedures, and processes.
  • Influence and participate in incident response planning and post-incident reviews, establishing measurable benchmarks.
  • Apply a DevSecOps mindset focused on automation, operational efficiency, and scalable architecture.
  • Drive security automation that increases team capacity for advanced work and reduces manual workload.
  • Stress-test security controls and platforms to validate performance while protecting business operations.
  • Coach, mentor, and lead engineering, development, and business partners on security-by-design and privacy-by-design principles.
Desired Qualifications
  • Experience with AWS or Azure cloud security tools and architectures.
  • AI/ML security experience, including model governance and secure MLOps.
  • Proficiency in scripting languages such as Python, PowerShell, JavaScript, PHP, or Ruby.
  • DevOps/DevSecOps background with compliance-driven engineering practices.
  • Knowledge of: ISO 27001, NIST, PCI DSS, HIPAA, HITECH, GDPR, CIS, SOC 2, and state privacy laws.
  • Strong strategic and tactical decision-making capabilities.
  • Highly trustworthy and leads with integrity and professionalism.
St. Jude Children's Research Hospital

St. Jude Children's Research Hospital

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St. Jude runs a nonprofit pediatric treatment and research center focused on childhood cancers, especially leukemia. It provides treatment and covers medical costs, travel, housing, and meals for patients and families, with no bills to families. Care comes from clinical treatment at the hospital while researchers develop therapies and run trials; results are shared openly with doctors worldwide. Its goal is to cure childhood cancer and relieve families’ financial burden by sharing knowledge globally.

Company Size

10,001+

Company Stage

Grant

Total Funding

$54.8M

Headquarters

Memphis, Tennessee

Founded

1962

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Simplify Jobs

Simplify's Take

What believers are saying

  • ARPA-H awarded up to $28.5 million on July 6, 2026 for gene-editing trials.
  • St. Jude and ALSAC raised record gala proceeds in May 2026, signaling donor momentum.
  • The April 2026 IRS4 study used AI to identify new cancer targets across tumor types.

What critics are saying

  • James R. Downing exits in late 2026, forcing a leadership transition during expansion.
  • A July 2026 discrimination lawsuit and prior accommodation litigation expose recurring employment friction.
  • Donation dependence is existential; 87% of six-year funding still relies on public contributions.

What makes St. Jude Children's Research Hospital unique

  • ALSAC funds St. Jude, preserving free care, housing, food, and travel for families.
  • St. Jude shares discoveries openly, accelerating global pediatric oncology research beyond Memphis.
  • The FY22-27 plan commits $11.5 billion, including ARC II and major clinical expansion.

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Benefits

Health Insurance

401(k) Retirement Plan

401(k) Company Match

Unlimited Paid Time Off

Maternity / Paternity Leave

Fertility Treatment Support

Adoption Assistance

Education Assistance

Enterprise Learning and Development

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