D

Dana-Farber Cancer Institute

Cancer treatment and research institute

Associate Director - Business Strategy

Full-Time
$125.8k - $146.2k
Senior
Bachelor's, Master's, MBA
Boston, MA, USA
RemoteRemote work is limited to New England states: Maine, Vermont, New Hampshire, Massachusetts, Connecticut, or Rhode Island. Occasional on-site time in Boston is required.
Business & StrategyCorporate Strategy

About the job

Requirements
  • A bachelor's degree in Business, Healthcare, or a related field is required.
  • At least 7 years of related work experience in healthcare strategy, management consulting, investment banking, or administrative functions in an academic medical center or cancer center setting is required.
  • Experience working with large datasets is required.
  • Experience working across multiple complex initiatives is required.
  • Advanced proficiency in Excel-based modeling, including volume forecasts, pro formas, and sensitivity and scenario analyses, is required.
  • Ability to interpret financial statements and operational data, with familiarity with cost accounting, is required.
  • Ability to design and track performance improvement initiatives and key performance indicators is required.
  • Extensive financial literacy in healthcare and/or research is required.
  • Ability to plan and execute change strategies and navigate ambiguity, resistance, and competing priorities while sustaining progress and adoption is required.
  • General understanding of healthcare regulatory and payer requirements, such as CMS policies, and their strategic and operational implications is required.
  • Ability to synthesize complex information, frame options, recommend actionable strategies, and exercise sound judgment and decision-making is required.
  • Ability to communicate in writing and verbally, present complex analyses clearly to executives, facilitate discussions, manage stakeholders, and build consensus across matrixed teams is required.
  • Demonstrated success partnering with clinical, research, education, operational, and administrative stakeholders and maintaining productive internal and external relationships is required.
  • Strong time management, attention to detail, follow-through, and discretion in handling confidential information are required.
Responsibilities
  • Lead the development of business strategies and long-range planning for strategic initiatives across departments, service lines, disease centers, and business units.
  • Develop long-term strategic plans, including scenario analysis, initiative planning, implementation planning, and stakeholder engagement.
  • Guide strategic planning at various organizational levels to ensure plans are data-driven and tied to organizational goals.
  • Support leaders in crafting business plans and business or funding cases that promote sustainable growth, operational excellence, and advancement of research or clinical initiatives aligned with leadership priorities and high-impact science and care.
  • Build rigorous business cases, as needed, for new programs, partnerships, capacity expansions, and technology investments.
  • Transition ownership of strategic initiatives to implementation leads while maintaining collaboration, oversight, and monitoring of progress and outcomes.
  • Coordinate input and leadership across clinical operations, disease centers, research, finance, and external partners.
  • Establish initiative charters, key performance indicators, and dashboards; manage governance forums and decision checkpoints; and ensure timely follow-up and accountability.
  • Develop change strategies and communications plans, and create presentations and materials tailored to executive and operational audiences.
Desired Qualifications
  • Experience working in the cancer sector or academic medicine is preferred.
  • Experience with research departments or institutions is preferred.
  • Experience working with clinical leaders as partners and advisers is preferred.
  • Experience optimizing clinical operations and improving patient care outcomes is preferred.
  • A master's degree, including MHA, MBA, or MPH, or a related degree is preferred.

About the company

D

Dana-Farber Cancer Institute

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Dana-Farber Cancer Institute provides cancer treatment and research services in Boston, serving both adult and pediatric patients. It combines patient care with a broad program of clinical trials and basic, translational, and collaborative research to advance cancer treatments. Treatments include personalized care and access to more than 700 clinical trials, aiming to tailor therapies to the patient’s tumor profile and disease type, often through targeted therapies, immunotherapy, chemotherapy, radiation, and surgical options offered at multiple treatment centers and satellite sites. The Institute differentiates itself through its affiliation with Harvard Medical School and Brigham and Women’s Hospital, its long history of cancer research breakthroughs, nationwide and international reach, and the Jimmy Fund to support patients and research. Its goal is to defeat cancer by delivering expert care while rapidly translating research discoveries into new treatments for patients everywhere.

Company Size

5,001-10,000

Company Stage

Grant

Total Funding

$54.9M

Headquarters

Boston, Massachusetts

Founded

1947

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What believers are saying

  • 2026-09 outpatient Brighton clinic adds 65 exam rooms and 83 infusion chairs.
  • 2026-08-26 $35 million Lubin gift funds construction, research, and patient support.
  • 2026-09-15 Dana-Farber/Boston Children's ranked the nation's top pediatric cancer program again.

What critics are saying

  • 2025-12-16 DOJ settlement forced Dana-Farber to pay $15 million for research fraud.
  • Mass General Brigham is building a rival cancer institute and unwinding Dana-Farber ties by 2028.
  • Physician assistant turmoil in 2026 exposed fragile staffing during the Brigham transition.

What makes Dana-Farber Cancer Institute unique

  • 2026-09-14 DESTINY-Lung04 showed Dana-Farber setting first-line HER2-mutant NSCLC standard.
  • 2026-09-10 Solavia embeds Dana-Farber oncology pathways into oncologists' electronic workflows.
  • Lavine Bekenstein Cancer Hospital, opening 2031, extends Dana-Farber's inpatient and ambulatory control.

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Benefits

  • Remote Work Options

Growth & Insights and Company News

Headcount

6 month growth

16%

1 year growth

16%

2 year growth

16%
Dana-Farber Cancer Institute
Oct 9th, 2026
Joyce Liu wins prestigious award from the National Cancer Institute.

Joyce Liu wins prestigious award from the National Cancer Institute. Posted date October 9, 2026 Joyce Liu, MD, MPH of Dana-Farber Cancer Institute is the recipient of the 2026 Michaele C. Christian Oncology Drug Development Award and Lectureship from the National Cancer Institute (NCI). The prestigious honor awarded annually recognizes individuals who have made significant contributions to the development of novel investigational agents for cancer therapy. Liu serves as associate chief and clinical research director of the Division of Gynecologic Oncology at Dana-Farber. In these roles, Liu has successfully developed and led multiple investigator-initiated and industry-sponsored phase 1 and 2 trials in GYN cancers, including early development of antibody-drug conjugates and combinations of PARP inhibitors with immuno-oncology agents. Her work has helped to establish the Dana-Farber GYN research program as a leading center for phase 1 and 2 trial development. Liu also serves as the associate clinical research officer for Dana-Farber. In presenting the award today, the National Cancer Institute stated, "Through her innovative clinical and translational research, Dr. Liu has advanced novel therapeutic strategies for ovarian and endometrial cancers, led practice-changing National Cancer Institute-sponsored clinical trials and championed the development of targeted therapies that have improved treatment options for patients worldwide." Liu's research focuses on identifying and validating novel therapies for gynecologic cancers, with an emphasis on rationally-designed, translationally-driven trials. Early in her career, she identified ErbB3 as a potential therapeutic target in ovarian cancer, leading to an international phase 2 trial of an ErbB3-directed antibody in conjunction with paclitaxel chemotherapy in recurrent platinum-resistant ovarian cancer. Dr. Liu also led the NCI-sponsored trial CTEP 8348 of combination cediranib and olaparib, which was the first trial to demonstrate the activity of combined anti-angiogenic and PARP inhibitor therapy in recurrent ovarian cancer. These results led to the NCI-sponsored international phase 3 NRG-GY004 trial comparing this combination to conventional chemotherapy in recurrent platinum-sensitive ovarian cancer, as well as CTEP 9825, a biomarker-driven phase 2 trial exploring potential biomarkers of sensitivity to this combination. Throughout her career, Liu has been an active member and leader within the NCI clinical trials network. Based upon work showing pre-clinical synergy between MEK inhibition and Bcl-xL inhibition in models of recurrent ovarian cancer, Liu developed and led CTEP 10597, a phase 1 trial testing the combination of cobimetinib with the Bcl-xL inhibitor pelcitoclax in recurrent ovarian and endometrial cancers, and she was an active contributor to CTEP 9525, a phase 1/2 study testing the combination of trametinib and navitoclax across solid tumors. Liu is also the current vice chair for the Ovarian Subcommittee of the NCI-funded NRG Oncology cooperative group. Liu is an active clinical trialist and is a principal investigator on multiple investigator-initiated and externally-sponsored interventional clinical studies in ovarian and endometrial cancer. She led the first trial demonstrating the clinical activity of WEE1 inhibition in uterine serous cancer and is a multi-PI of a P01 grant stemming from this work that is focused on understanding the role of replication stress in high-grade endometrial cancers. She also leads the Dana-Farber Gynecologic Oncology Division's translational modeling efforts and has developed panels of patient-derived xenograft and organoid models of ovarian and endometrial cancers that have provided insights into multiple novel therapeutic targets. Liu joins Panos Konstantinopoulos, MD, PhD (2022) and Geoff Shapiro, MD, PhD (2013) as Dana-Farber recipients of the Michaele C. Christian Oncology Drug Development Award. Gynecologic Cancer Related Doctors and Researchers Media Contacts If you are a journalist and have a question about this story, please call 617-632-4090 and ask to speak to a member of the media team, or email [email protected]. The Media Team cannot respond to patient inquiries. For more information, please see Contact Us. Joyce F. Liu, MD, MPH

Dana-Farber Cancer Institute
Oct 9th, 2026
Seth Karp, MD, and Gavin Dunn MD, PhD, join Dana-Farber Cancer Institute.

Seth Karp, MD, and Gavin Dunn MD, PhD, join Dana-Farber Cancer Institute. Posted date October 9, 2026 This week, two distinguished leaders joined Dana-Farber Cancer Institute: Seth Karp, MD, began his new role as Chair of Surgery, and Gavin P. Dunn, MD, PhD, is now Neurosurgeon-in-Chief at the Institute. Dr. Karp also serves as Chair of the Roberta and Stephen R. Weiner Department of Surgery at Beth Israel Deaconess Medical Center (BIDMC), and will play a central role in the Dana-Farber Beth Israel Deaconess Cancer Collaboration, which will bring together world-class clinicians to deliver transformational, precision medicine in an environment solely dedicated to defying cancer. Dr. Dunn is the inaugural Chair of a new Department of Neurosurgery at Beth Israel Deaconess Medical Center and Harvard Medical Faculty Physicians. As Neurosurgeon-in-Chief, he will work with clinical leaders at Dana-Farber on the coordination and delivery of neurosurgical services as part of multidisciplinary oncology care as part of Dana-Farber's clinical collaboration with BIDMC. "I am thrilled to welcome Seth Karp and Gavin Dunn, two highly respected leaders and researchers, to Dana-Farber," said Benjamin L. Ebert, MD, PhD, president and CEO of Dana-Farber Cancer Institute. "Through our clinical collaboration with BIDMC, they will foster effective multidisciplinary care for patients and their families through world-class clinical services and innovation." Previously, Dr. Karp served as Chair of the Section of Surgical Sciences and System Surgeon-in-Chief at Vanderbilt University Medical Center. He was the H. William Scott Jr. Chair in Surgery and Professor of Surgery, Biomedical Ethics and Society, and Anesthesiology at Vanderbilt University School of Medicine. He joined the Vanderbilt faculty as Director of the Vanderbilt Transplant Center in 2011, and over the next 15 years, the Center became the largest in the United States. Dr. Karp is nationally known for his expertise in liver transplantation including the use of marginal grafts, and organ procurement and allocation. He has provided congressional testimony three times regarding national transplant policy. Dr. Karp has held numerous leadership positions in the American Society of Transplant Surgeons and the Organ Procurement and Transplantation Network and United Network for Organ Sharing (UNOS). He is former deputy editor of the American Journal of Transplantation, and a fellow of the American Surgical Association, American College of Surgeons, and Southern Surgical Association. Dr. Karp's clinical research interests include increasing the number of organs available for transplantation, improving organ procurement organization performance, and understanding and improving health for rural and underserved populations. His basic research examines the mechanisms of liver regeneration and treatment of monogenetic liver disease in children. Dr. Karp received his undergraduate degree in physics and astrophysics and his master's degree in astrophysics from Harvard University, and his medical degree from the joint Harvard/MIT program in health sciences and technology. He completed his residency at Brigham and Women's Hospital and transplant fellowship at The Johns Hopkins Hospital. Prior to joining Dana-Farber, Dr. Dunn served as Director of the Brain Tumor Immunology and Immunotherapy Program at Massachusetts General Hospital, where his clinical practice focused on caring for patients with primary and metastatic brain cancers, as well as general neurosurgical conditions. He is also a Professor of Neurosurgery at Harvard Medical School and a Captain in the United States Navy Reserves Medical Corps. Dr. Dunn is a Fellow and Member of the American Association of Neurological Surgeons, and a Member of the Congress of Neurological Surgeons and Society for Immunotherapy of Cancer. He also has served on the Board of Directors of the Society for Neuro-Oncology. Dr. Dunn's NIH-funded research focuses on understanding the immune response to brain tumors and the fundamental basis of CNS immunobiology. His work on the Brain Tumor Immunity cycle involves preclinical models and translational work that has resulted in the development of novel personalized cancer vaccine clinical studies. He is a co-chair of a clinical trial through the Alliance for Clinical Trials in Neuro-Oncology focused on recurrent glioblastoma. Dr. Dunn earned his undergraduate degree in molecular biology from Princeton University and his medical degree and PhD in immunology from Washington University in St. Louis. He completed his neurosurgery residency training at Massachusetts General Hospital and was a postdoctoral fellow with Executive Vice President & Chief Operating and Transformation Officer William C. Hahn, MD, PhD, at the Broad Institute and Dana-Farber Cancer Institute. Media Contacts If you are a journalist and have a question about this story, please call 617-632-4090 and ask to speak to a member of the media team, or email [email protected]. The Media Team cannot respond to patient inquiries. For more information, please see Contact Us. Seth Karp, MD, Chair of Surgery Gavin P. Dunn, MD, PhD, Neurosurgeon-in-Chief

Healthcare Industry Today
Oct 7th, 2026
Upstage Lung Cancer presents Barry Manilow Tribute concert to support Lung Cancer research.

Upstage Lung Cancer presents Barry Manilow Tribute concert to support Lung Cancer research. Upstage Lung Cancer founder Hildy Grossman performs with fellow singers at a previous Upstage Lung Cancer benefit concert. Emmy Award-Winning Joyce Kulhawik Hosts Upstage Lung Cancer's 18th Annual Benefit Concert in Watertown, MA WATERTOWN, MA, UNITED STATES, October 7, 2026 / EINPresswire.com / - Upstage Lung Cancer (ULC), a nonprofit organization using the power of the performing arts to create awareness and fund lung cancer research, announces its 18th annual benefit concert, BARRY MANILOW: A Concert Tribute to a Master Showman. The live event takes place Tuesday, October 27, 2026, at 7:30 PM at the Mosesian Center for the Arts in Watertown, MA. Upstage Lung Cancer's 18th annual fall concert celebrates the music and legacy of Barry Manilow, Billboard's #1 Adult Contemporary Artist of all time. This year's benefit concert extends the urgent message that anyone with lungs can get lung cancer. In December 2025, doctors announced that they had found a stage-one cancerous tumor in Barry Manilow's left lung. Manilow said he never expected lung cancer would happen to him, but thanks to the early detection, his medical team was optimistic. "It's pure luck (and a great doctor) that it was found so early," Manilow said. This narrative is familiar to ULC founder and survivor Hildy Grossman, whose own cancer was found by accident. Upstage Lung Cancer's core mission is to ensure early detection is driven by accessible screening and innovative diagnostics, not by chance or accident. "Music has a unique ability to unite people around a shared cause," says Grossman. "Honoring Barry Manilow's timeless catalogue, while supporting lung cancer research, offers an evening of immense joy for a vital, life-saving purpose." The evening will be hosted by Emmy Award-winning arts and entertainment critic Joyce Kulhawik. Featured vocalists include acclaimed performers Brian De Lorenzo, Hildy Grossman of The Follen Angels, Michael Hammond of The Company Theatre, and Paula Markowicz of Divas With A Twist. Musical accompaniment will be provided by The Follen Angels band. The concert will also include the announcement of ULC's annual Fan Award to Bianca Bye and Leah Phillips, founders of the Young Lung Cancer Initiative. Other guests include Francine Jacobson, MD, MPH, thoracic radiologist, and Lauren Coye, young lung cancer survivor. About Upstage Lung Cancer Upstage Lung Cancer is a cancer advocacy organization that uses music and the performing arts to increase awareness, de-stigmatize lung cancer, and raise funds for early detection research. ULC founder, lung cancer survivor and jazz recording artist Hildy Grossman, lead singer of The Follen Angels, has combined her passion for music with her desire to foster knowledge about the leading cause of cancer death, with the goal of spotlighting new directions in lung cancer research and early detection. Over the past 20 years, Upstage Lung Cancer has funded more than $4.5 million in early detection research grants, investing in research opportunities. This year, grants were awarded to leading doctors at Massachusetts General Hospital, Boston Children's Hospital, and the Koch Institute at MIT. Upstage Lung Cancer maintains ongoing partnerships with LUNGevity Foundation, GO2 for Lung Cancer, Dana-Farber Cancer Institute, and Koch Institute at MIT. Ticket & Registration Information Proceeds support lung cancer research and early-detection initiatives. Date: Tuesday, October 27, 2026 Time: 7:30 PM EDT Location: Mosesian Center for the Arts, Watertown, MA Hildy Grossman Upstage Lung Cancer +1 617 835 9722 [email protected] Visit Healthcare Industry Today on social media: LinkedIn Instagram Facebook YouTube TikTok X Legal Disclaimer: EIN Presswire provides this news content "as is" without warranty of any kind. Healthcare Industry Today do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the author above.

Beth Israel Deaconess Medical Center
Oct 6th, 2026
BIDMC welcomes new Surgery and neurosurgery leaders.

BIDMC welcomes new Surgery and neurosurgery leaders. October 06, 2026 Seth Karp, MD, named Chair of Roberta and Stephen R. Weiner Department of Surgery; gavin P. Dunn, MD, PhD, appointed Chair of new Department of Neurosurgery. BOSTON - Beth Israel Deaconess Medical Center (BIDMC) today announced the appointment of distinguished leaders to advance the future of surgical and neurosurgical care across the hospital. Seth Karp, MD, has joined BIDMC as the Chair of the Roberta and Stephen R. Weiner Department of Surgery. Karp will also serve as the Chair of Surgery at Dana-Farber Cancer Institute. Gavin P. Dunn, MD, PhD, has been appointed as the inaugural Chair of the new Department of Neurosurgery and the Neurosurgeon-in-Chief at Dana-Farber Cancer Institute. In these leadership positions, Dr. Karp and Dr. Dunn will also work to support the Dana-Farber Beth Israel Deaconess Cancer Collaboration, which will bring together world-class clinicians to deliver transformational, precision medicine in an environment solely dedicated to defying cancer. "Dr. Karp and Dr. Dunn are both renowned in their fields and will add their wisdom and expertise to our growing teams in surgery and neurosurgery for our patients and their families," said Pete Healy, president, BIDMC, and divisional president, Metro Boston, Beth Israel Lahey Health. "They will be key leaders as we continue to shape the cancer collaboration with Dana-Farber and deliver the future of cancer care to the region." "This is an exciting time of growth for our surgery programs, and we are pleased to welcome Dr. Karp and Dr. Dunn as respected leaders to lead the way forward," said Alexa B. Kimball, president & CEO, Harvard Medical Faculty Physicians at BIDMC (HMFP). "They are both talented surgeons, researchers and educators with strong commitments to excellence and patient-centered care." "I am honored to join BIDMC and HMFP as we enhance surgical care within both organizations," said Karp. "Together, we will advance clinical excellence and quality by building dedicated, cohesive teams that develop and integrate pioneering research into caring for our patients." "BIDMC is committed to advancing groundbreaking research, education and high-quality patient care in the neurosciences," said Dunn. "I look forward to working with the outstanding clinicians in our newly established department, where we will be able to build on a strong foundation to grow our program." About seth Karp, MD. Since 2018, Dr. Karp served as Chair of the Section of Surgical Sciences and System Surgeon-in-Chief at Vanderbilt University Medical Center. He was the H. William Scott Jr. Chair in Surgery and Professor of Surgery, Biomedical Ethics and Society, and Anesthesiology at Vanderbilt University School of Medicine. He joined the Vanderbilt faculty as Director of the Vanderbilt Transplant Center in 2011, a position he held for 11 years, over which time the Center became the largest in the United States, performing nearly 1,000 solid-organ transplants per year, and was named Chair of the Department of Surgery in 2015. Dr. Karp is nationally known for his expertise in liver transplantation, transplant system performance and the use of marginal grafts. He has held numerous leadership positions in the American Society of Transplant Surgeons, Organ Procurement and Transplantation Network and United Network for Organ Sharing (UNOS) and testified in front of Congress three times on organ policy. He served as Deputy editor of the American Journal of Transplantation. He is a fellow of the American Surgical Association, American College of Surgeons and Southern Surgical Association. His clinical research interests include increasing the number of organs available for transplantation, optimizing the use of organs, and understanding and improving health for rural and underserved populations. His basic research interests are in molecules and mechanisms necessary for liver regeneration, and curing monogenic liver disease in children. Dr. Karp received his undergraduate degree in physics and astrophysics and his master's degree in astrophysics from Harvard University and his medical degree from the joint Harvard/MIT program in health sciences and technology. He completed his residency at Brigham and Women's Hospital and transplant fellowship at The Johns Hopkins Hospital. About gavin P. Dunn. A respected neurosurgeon and researcher, Dr. Dunn specializes in neurosurgical oncology. He most recently served as Director of the Brain Tumor Immunology and Immunotherapy Program at Massachusetts General Hospital, where his clinical practice focuses on caring for patients with primary and metastatic brain cancers, as well as general neurosurgical conditions. He is also a Professor of Neurosurgery at Harvard Medical School and a Captain in the United States Navy Reserves Medical Corps. He is a fellow and member of the American Association of Neurological Surgeons, a member of the Congress of Neurological Surgeons, Society for Immunotherapy of Cancer, and has served on the Board of Directors of the Society for Neuro-Oncology. Dr. Dunn's NIH-funded research focuses on understanding the immune response to brain tumors and the fundamental basis of CNS immunobiology. His work on the Brain Tumor Immunity cycle involves preclinical models and translational work that has resulted in the development of novel personalized cancer vaccine clinical studies. He is a prior Cancer Research Institute Lloyd J. Old STAR award recipient and co-chair of a clinical trial through the Alliance for Clinical Trials in Neuro-Oncology focused on recurrent glioblastoma. Dr. Dunn earned his undergraduate degree in molecular biology from Princeton University and his medical degree and PhD in immunology from Washington University in St. Louis. He completed his neurosurgery residency training at Massachusetts General Hospital and was a postdoctoral fellow at the Broad Institute and Dana-Farber Cancer Institute. About Beth Israel Deaconess Medical Center. Beth Israel Deaconess Medical Center is a leading academic medical center, where extraordinary care is supported by high-quality education and research. BIDMC is a teaching affiliate of Harvard Medical School, and consistently ranks as a national leader among independent hospitals in National Institutes of Health funding. BIDMC is the official hospital of the Boston Red Sox. Beth Israel Deaconess Medical Center is a part of Beth Israel Lahey Health, a healthcare system that brings together academic medical centers and teaching hospitals, community and specialty hospitals, more than 4,700 physicians and 39,000 employees in a shared mission to expand access to great care and advance the science and practice of medicine through groundbreaking research and education. Media Relations Manager Kim lucey. Please note: The contact information above is for journalists and news media only. For patient care and all other inquiries, please contact your doctor or BIDMC directly.

Dana-Farber Cancer Institute
Oct 6th, 2026
Two Dana-Farber researchers receive prestigious New Innovator Award from the National Institutes of Health.

Two Dana-Farber researchers receive prestigious New Innovator Award from the National Institutes of Health. Posted date October 6, 2026 Xin Gu, PhD, and Nicholas Polizzi, PhD, of Dana-Farber Cancer Institute have received New Innovator Awards from the National Institutes of Health (NIH) High-Risk, High-Reward Research program. The prestigious award supports early career investigators pursuing highly innovative research with the potential for broad impact on biomedical and behavioral science. Gu, an independent investigator in the Dana-Farber Department of Cancer Biology and assistant professor in the Harvard Medical School Department of Cell Biology, and Polizzi, an independent investigator in the Dana-Farber Department of Cancer Biology and assistant professor in the Harvard Medical School Department of Biological Chemistry and Molecular Pharmacology, will each receive $2.375 million in funding over five years to further their impact and address challenges related to biomedical science. Gu was awarded grant number DP2CA325381-01, and Polizzi received grant number DP2GM170825-01. Established at Dana-Farber in September 2024, the Xi Gu Lab elucidates molecular mechanisms that are key for cellular homeostasis, including nuclear protein turnover by a novel ubiquitin-independent mechanism: the midnolin-proteasome pathway. The Gu lab aims to discover more ubiquitin-independent protein degradation pathways naturally used by cells, define their biochemical mechanisms and harness them for therapeutic applications. Gu has been recognized with several prior awards, including the Damon Runyon-Dale F. Frey Award for Breakthrough Scientists, a Klingenstein Fellowship Award in Neuroscience, a Smith Family Foundation Award for Excellence in Biomedical Research and selection as a Pew Biomedical Scholar. The Polizzi Lab uses protein design to study how proteins bind to small molecules. Polizzi's team uses deep learning to create novel biosensors for cancer therapeutics and protein-based tools for chemical biology. By designing proteins from scratch that bind small-molecule drugs, the team is investigating how proteins change shape upon drug binding, which in turn affects their function. This work not only elucidates how human proteins could be more effectively drugged, but also creates new ways to make existing drugs safer. Polizzi previously was the recipient of an NIH K99/R00 Pathway to Independence award and has received high-risk, high-reward research funding from the W. M. Keck Foundation. The NIH Common Fund High-Risk, High-Reward Research program supports researchers at different career stages who propose highly innovative research that may be difficult to pursue with traditional NIH funding mechanisms. The program consists of four awards: The NIH Director's Pioneer Award, New Innovator Award, Transformative Research Award and Early Independence Award. This year, 58 research grants were awarded, totaling approximately $237.5 million, to support investigators pursuing bold ideas that challenge conventional approaches and could open new pathways to scientific discovery. In addition to the NIH Common Fund, funding comes from the National Institute of Environmental Health Sciences (NIEHS), the National Institute on Deafness and Other Communication Disorders (NIDCD) and the Office of Research Innovation, Validation and Application (ORIVA). Cancer Biology Related Doctors and Researchers Media Contacts If you are a journalist and have a question about this story, please call 617-632-4090 and ask to speak to a member of the media team, or email [email protected]. The Media Team cannot respond to patient inquiries. For more information, please see Contact Us. Xin Gu, PhD Nicholas Polizzi, PhD