Senior Systems Engineer

Overview

Systems Mechanical Engineer Next Generation Liquid Chromatography (NGLC) Systems Group

Join a team at the forefront of innovation in analytical science and help define the future of liquid chromatography.

As a Systems Engineer within the Next Generation Liquid Chromatography (NGLC) Systems Group, you will play a pivotal role in the creation of industry-leading chromatography solutions that advance scientific discovery, pharmaceutical development, and quality assurance worldwide. Working at the intersection of customer needs, business strategy, and technology innovation, you will help transform bold product concepts into commercially successful products that set new standards for performance, usability, connectivity, and customer value.

This highly collaborative and hands-on role requires a versatile engineer who thrives in multidisciplinary environments. You will work closely with Product Management, Marketing, Software, Electrical, Mechanical, Quality, Regulatory, Service, Manufacturing, and Commercial teams to define product capabilities, develop system requirements, guide technical decision-making, and verify that innovative solutions deliver exceptional customer outcomes.

From early product ideation through system integration and launch, you will influence every stage of development—combining systems thinking, technical leadership, and practical engineering execution. Whether defining next-generation workflows, developing system architectures, executing hands-on testing, or solving complex integration challenges, you will play a key role in bringing breakthrough technologies to market.

This is a unique opportunity to shape the future of liquid chromatography while working alongside some of the industry's leading scientists, engineers, and product innovators.

Responsibilities

• Collaborate with Product Management, Marketing, and Engineering teams to define next-generation liquid chromatography products and customer solutions.
• Translate customer, business, and market needs into clear, testable, and traceable system requirements.
• Develop and maintain system requirements, product requirements, interface definitions, and traceability documentation throughout the product development lifecycle.
• Partner with software, electrical, mechanical, scientific, and manufacturing teams to develop innovative system-level solutions.
• Support system architecture development and technical decision-making by evaluating design alternatives, tradeoffs, and risks.
• Lead cross-functional discussions to align requirements, resolve technical challenges, and drive project execution.
• Develop system verification and validation strategies, test plans, and acceptance criteria.
• Perform hands-on testing, integration, troubleshooting, and performance characterization of prototype and production systems.
• Investigate system-level issues, perform root cause analysis, and drive corrective actions to resolution.
• Support risk management activities by identifying technical risks and developing mitigation strategies.
• Promote systems engineering best practices including requirements management, systems integration, design verification, and traceability.
• Provide technical leadership within project teams and mentor junior engineers in systems engineering methodologies.
• Support successful commercialization of industry-leading chromatography solutions from concept through product launch.

Qualifications

• Bachelor's degree in Systems Engineering, Mechanical Engineering, Electrical Engineering, Biomedical Engineering, Chemical Engineering, Computer Science, Software Engineering, Physical Sciences, Chemistry, or a related technical discipline.
• 3+ years of experience in systems engineering, product development, analytical instrumentation, or multidisciplinary engineering environments.
• Demonstrated experience developing complex hardware and software products from concept through commercialization.
• Experience translating customer needs and business objectives into system requirements and product capabilities.
• Experience working across multiple engineering disciplines, including software, electrical, mechanical, and scientific teams.
• Strong understanding of systems engineering principles, including requirements development, requirements decomposition, traceability, integration, verification, validation, and risk management.
• Experience planning and executing system-level testing and troubleshooting activities.
• Excellent problem-solving and root-cause analysis skills.
• Strong written, verbal, and interpersonal communication skills with the ability to effectively collaborate across organizational boundaries.
• Demonstrated ability to lead technical initiatives and influence outcomes without direct authority.

Preferred Qualifications

• Master's degree in Engineering, Computer Science, Physical Sciences, Chemistry, Biomedical Engineering, or a related technical field.
• Direct experience designing, developing, integrating, servicing, supporting, or operating HPLC, UHPLC, liquid chromatography, mass spectrometry, or other analytical instrumentation platforms strongly preferred.
• Strong understanding of chromatography workflows, laboratory operations, and customer applications in pharmaceutical, biopharmaceutical, chemical, food, environmental, or clinical markets.
• Experience developing complex electromechanical products involving fluidics, sensors, automation, software, firmware, and data systems.
• Experience with system architecture, technology development, and new product introduction activities.
• Familiarity with cybersecurity, connectivity, cloud-enabled products, laboratory informatics, and data management platforms.
• Experience with Design Controls, Risk Management, Verification & Validation, and regulated product development processes.
• Experience using requirements management and systems engineering tools such as Jama, DOORS, Polarion, Azure DevOps, or equivalent.
• Experience mentoring engineers and leading cross-functional technical activities.
• Knowledge of liquid chromatography system design considerations such as solvent delivery, sample management, detector technologies, thermal management, and laboratory workflow integration is a plus+

Company Description

Waters Corporation (NYSE:WAT)  is a global leader in life sciences and diagnostics, dedicated to accelerating the benefits of pioneering science through analytical technologies, informatics, and service. With a focus on regulated, high-volume testing environments, our innovative portfolio harnesses deep scientific expertise across chemistry, physics, and biology. We collaborate with customers around the world to advance the release of effective, high-quality medicines, ensure the safety of food and water, and drive better patient outcomes by detecting diseases earlier, managing routine infections, and combating antibiotic resistance. Through a shared culture of relentless innovation, our passionate team of ~16,000 colleagues turn scientific challenges into breakthroughs that improve lives worldwide.  

Diversity and inclusion are fundamental to our core values at Waters Corporation. It benefits our employees, our products, our customers and our community. Waters complies with all applicable federal, state, and local laws. Qualified applicants are considered without regard to sex, race, color, ancestry, national origin, citizenship status, religion, age, marital status (including civil unions), military service, veteran status, pregnancy (including childbirth and related medical conditions), genetic information, sexual orientation, gender identity, legally recognized disability, domestic violence victim status, or any other characteristic protected by law. Waters is proud to be an equal opportunity workplace and is an affirmative action employer. All hiring decisions are based solely on qualifications, merit, and business needs at the time.

Key Words

#SystemsEngineering #ProductDevelopment #SystemArchitecture #RequirementsEngineering #System Integration #Verification #Validation Cross-Functional Leadership Technical Leadership #HPLC #UHPLC #LiquidChromatography Analytical Instrumentation Laboratory Automation Fluidics New Product Development