A

Axle

Translational research informatics and data science

IT Operations Technical Lead

Full-Time
$150k - $170k
Expert
Frederick, MD, USA
In Person
IT OperationsSystem Administration

About the job

Requirements
  • At least 5 years of experience leading operations teams, including hands-on experience driving operational process improvements and technological advancements.
  • Proven experience implementing and operating within Information Technology Infrastructure Library (ITIL) frameworks.
  • At least 10 years of hands-on Unix/Linux experience, including CentOS or Red Hat systems administration support for large-scale distributed environments.
  • Hands-on experience with incident management, patching, system hardening, and production support.
  • Experience building and maintaining golden images and standardized environments.
  • Strong scripting and automation skills using Python, Bash, PowerShell, or similar tools.
  • Experience with configuration management and automation tools such as Ansible, Terraform, Puppet, or Chef.
  • Strong understanding of networking fundamentals, including DNS, TCP/IP, firewalls, and load balancing.
  • Experience with monitoring and logging tools such as Nagios, Splunk, ELK, Prometheus, or Grafana.
  • Cloud build-out or migration experience with at least one of Amazon Web Services, Google Cloud Platform, or Microsoft Azure.
  • At least 2 years of experience with continuous integration and continuous delivery and automation tools such as Terraform, Ansible, Chef, Puppet, Jenkins, or GitHub.
  • Experience supporting artificial intelligence/machine learning workloads or data-intensive platforms.
  • Familiarity with GPU-based compute environments, such as NVIDIA GPU instances.
  • Willingness to learn new technologies and adapt to emerging technologies or changing project needs.
Responsibilities
  • Lead and manage IT operations aligned with ITIL processes, including incident, problem, change, and release management.
  • Provide hands-on leadership in managing Linux and Windows environments across cloud and on-premises infrastructure.
  • Own and drive incident response, root cause analysis, and service restoration for mission-critical systems.
  • Design, build, and maintain golden images, patching strategies, and system-hardening standards.
  • Lead patch management and vulnerability remediation programs to ensure compliance and system integrity.
  • Develop and implement automation solutions, including AI-assisted development, to accelerate operational efficiency and reduce toil.
  • Support and optimize infrastructure for AI/ML workloads, including provisioning, scaling, and performance tuning.
  • Manage and maintain GPU-enabled environments and instances for high-performance computing and machine-learning use cases.
  • Oversee and optimize infrastructure monitoring, logging, alerting, and observability frameworks.
  • Manage and mentor a team of systems engineers, providing technical guidance and performance oversight.
  • Collaborate with architecture, security, and development teams to improve reliability, scalability, and operational efficiency.
  • Support hybrid environments, including cloud platforms and on-premises data centers.
  • Ensure proper documentation, runbooks, standard operating procedures, and operational readiness.
  • Stay abreast of technologies including U.S. federal standards, National Institute of Standards and Technology publications, cloud computing and deployment, site reliability engineering, security standards, and compliance best practices.
Desired Qualifications
  • Knowledge of security best practices and compliance frameworks such as NIST 800-53, FedRAMP, and FISMA.
  • Certifications such as ITIL, Linux, AWS, Azure, or Kubernetes (CKA/CKAD).
  • Networking certifications such as CCNA or CCNP.

About the company

Axle Informatics provides specialized informatics solutions for translational research, health informatics, and data science to biomedical research centers and healthcare organizations. Its offerings are customized software and data management platforms that help researchers collect, integrate, analyze, and visualize large research datasets, with end-to-end tools that automate data aggregation and deliver analytics, dashboards, and decision-support features. The company differentiates itself with an integrated, scientifically informed approach that bridges data science with application development, specifically focused on translational research and clinical data work rather than generic software. Axle’s goal is to advance public health by moving biomedical discoveries from the lab to bedside, improving healthcare outcomes.

Company Size

201-500

Company Stage

N/A

Total Funding

N/A

Headquarters

Rockville, Maryland

Founded

2002

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Simplify's Take

What believers are saying

  • Axle secured a $21 million NCATS support contract starting February 2025.
  • Axle won a 2026 NHLBI systems biology task for single-cell genomics work.
  • Axle’s May 2026 NIH and SK pharmteco partnership expands credibility in rare-disease gene therapy.

What critics are saying

  • NIH concentration makes Axle vulnerable if NCATS and NHLBI rebid work in 2026.
  • Axle filed and lost GAO protests in August 2026, signaling procurement pressure.
  • Federal budget lapses instantly freeze specialized scientific services; Axle’s core contracts depend on appropriated NIH funding.

What makes Axle unique

  • Axle Informatics won NIH NCATS and NHLBI work in 2025-2026.
  • Axle combines biomedical staff scientists, cloud engineering, and translational research program management.
  • Axle’s NIH foothold includes rare-disease gene therapy collaboration with SK pharmteco, May 2026.

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Benefits

Health Insurance

Dental Insurance

Vision Insurance

Paid Vacation

Paid Holidays

401(k) Company Match

Educational Benefits for Career Growth

Employee Referral Bonus

Flexible Spending Accounts

Company News

TheGWW.com
Jul 25th, 2023
“Octo awarded $64.7M IT Infrastructure Call Order to support NCI’s Cancer research”

Octo, in partnership with Unissant, Axle Informatics, and TRex, has been awarded an IT Infrastructure and Operations Call Order to support the NCI’s OCIO.

GlobeNewswire
Jan 12th, 2023
Digital Pathology Market Worth $1.86 Billion by 2030 -

For instance, in May 2020, Indica Labs (U.S.), a provider of digital pathology solutions, collaborated with information technology consulting companies, Octo (U.S.) and Axle Informatics (U.S.) and the National Institutes of Health (NIH) (U.S.), to develop an online collection of high-resolution histopathology images of tissues from COVID-19 patients using Indica’s HALO Link platform.